Associations Between Interleukin-8 Receptor (Cxcr1) and Interleukin-6 (Il6) Polymorphism and Immunity to Mastitis in the Black-and-White Variety of Polish Holstein-Friesian Cows

Abstract

The study involved 448 Black-and-White Holstein-Friesian cows. All animals came from one herd, they were kept in the same barn and in the same environmental conditions. Complete phenotypic data on the studied animals was collected. The aim of the research was to search for possible associations between SNPs in the CXCR1 and IL6 genes and mastitis. Identification of specific SNPs was possible due to the use of the PCR-ARMS method. Statistically significant associations were found between the analysed SNPs and resistance to mastitis and selected milk production traits.

Novel Nucleotides Polymorphism in CXTCR2 Gene Associated with Mastitis In River Buffalo, Egyptian Breed

“…In cattle, CXCR1 was more investigated than CXCR2. CXCR1 SNPs in cattle were significantly associated with mastitis resistance [18][19][20][21]. Significant association between CXCR1 c.337A> G and c.365C>T and somatic cell scores (SCS) in Chinese native cattle were also reported [23].…”

“…They recognize chemokines causing neutrophil activation that end in phagocytosis of the pathogen [17]. Several studies reported a significant association of O Egyptian Journal of Veterinary Sciences https://ejvs.journals.ekb.eg/ CXCR1 SNPs with resistance to mastitis [18,19,20,21] and can influence somatic cell count [22] in cattle. Significant association between CXCR1 c.337A> G and c.365C>T and somatic cell scores (SCS) in Chinese native cattle was reported by Zhou et al [23].…”