Associations between inflammatory markers and muscle strength in older adults according to the presence or absence of obesity

Ribeiro, Julio Cesar; Duarte, Juliana Gomes; Gomes, Grace Angélica de Oliveira; Costa-Guarisco, Letícia Pimenta; Jesus, Isabela Thaís Machado de; Nascimento, Carla Manuela Crispim; Santos-Orlandi, Ariene Angelini dos; Orlandi, Fabiana de Souza; Vasilceac, Fernando Augusto; Zazzetta, Marisa Silvana; Pott-Júnior, Henrique; Cominetti, Márcia Regina

doi:10.1016/j.exger.2021.111409

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Similar previous research only examined the role of the association of inflammatory markers in the youngest-old [25]. However, differences in results may be related to differences in obesity assessment methods, such as the use of BMI or differences in the research population [25,26].…”

Section: Discussionmentioning

confidence: 80%

“…This may demonstrate the crucial role of IL-6 during aging. However, one study found no difference in IL-6, IL-10, TNF-α, TNF-β, and IL-1β between older adults with DO or older adults with only dynapenia [25] and another study showed that between IL-6, IL-10, and TNF-α, only the last two had lower and higher levels, respectively, in the DO group compared to the obese, non-obese, or low-strength group [26]. Similar previous research only examined the role of the association of inflammatory markers in the youngest-old [25].…”

Section: Discussionmentioning

confidence: 99%

“…However, one study found no difference in IL-6, IL-10, TNF-α, TNF-β, and IL-1β between older adults with DO or older adults with only dynapenia [25] and another study showed that between IL-6, IL-10, and TNF-α, only the last two had lower and higher levels, respectively, in the DO group compared to the obese, non-obese, or low-strength group [26]. Similar previous research only examined the role of the association of inflammatory markers in the youngest-old [25]. However, differences in results may be related to differences in obesity assessment methods, such as the use of BMI or differences in the research population [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, deficits in the structure and function of the intrinsic force-generating properties of skeletal muscle are potential antecedents of dynapenia [7]. Thus, screening to clarify this decline becomes an essential geriatric clinical parameter [8] Furthermore, studies showed an association between a pro-inflammatory condition and DO in the youngest-old and middle-old [25,26]. However, the literature still lacks data on the oldest old with and without DO and its relationship with inflammation and muscle quality.…”

Section: Introductionmentioning

confidence: 99%

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Influence of dynapenic obesity on inflammation and muscle quality in oldest-old patients

Rosa,

Garcia,

Sousa Neto

et al. 2024

Rev Bras Fisiol Exerc

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Introduction: Aging is associated with a decrease in strength (dynapenia) and an increase in body fat. Both obesity and dynapenia negatively influence health in the oldest old. When these two variables coexist, called dynapenic obesity (DO), these further harms the older adult's health. Objective: To verify the influence of dynapenic obesity on inflammation, physical performance, and muscle quality in the oldest old with and without DO. Methods: Forty-six oldest old participants were included in this study, and sociodemographic, muscle strength, body composition, physical performance, and cytokine data were collected. The sample was divided into DO and control groups to compare the variables. Results: The DO group had higher levels of inflammation, lower levels of absolute handgrip strength, and field muscle quality index than the control group, but with no difference in physical performance or laboratory muscle quality index. Conclusion: Therefore, this study points to dynapenic obesity as an important variable that should be evaluated and considered in the oldest old to prevent possible adverse outcomes in this population.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of dynapenic obesity on inflammation and muscle quality in oldest-old patients

Rosa,

Garcia,

Sousa Neto

et al. 2024

Rev Bras Fisiol Exerc

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“…Obesity is one of the major conditions that gives rise to a myriad of comorbid, inflammation driven, chronic diseases particularly as aging progresses [62,63]. Table 2 illustrates examples of 43 comorbid NCDs for obesity .…”

Section: Obesitymentioning

confidence: 99%

Microbiome First Medicine in Health and Safety

Dietert¹

2021

Preprint

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Microbiome First Medicine is a suggested 21st century healthcare paradigm that prioritizes the entire human, the human superorganism, beginning with the microbiome. To date, much of medicine has protected and treated patients as if they were a single species. This has resulted in unintended damage to the microbiome and an epidemic of chronic disorders [e.g., noncommunicable diseases and conditions (NCDs)]. Along with NCDs came loss of colonization re-sistance, increased susceptibility to infectious diseases, and increasing multimorbidity and polypharmacy over the life course. To move toward sustainable healthcare, the human micro-biome needs to be front and center. This paper presents microbiome-human physiology from the view of systems biology regulation. It also details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome. Examples are provided for two entryway NCDs, asthma and obesity, regarding their extensive network of comorbid NCDs. Finally, the challenges of ensuring safety for the microbiome are detailed. Under Microbiome First Medicine and considering the importance of keystone bacteria and critical windows of development, changes in even a few microbiota-prioritized medical decisions could make a significant difference in health across the life course.

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