Associations Between Infiltrating Lymphocyte Subsets and Hepatocellular Carcinoma

Guo, CunLi; Yang, Haichao; Yang, Xiuhua; Cheng, Wen; Dong, Tianxiu; Zhu, Wenjing; Xu, Zheng; Zhao, Liang

doi:10.7314/apjcp.2012.13.11.5909

Cited by 41 publications

(35 citation statements)

References 19 publications

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“…Although hepatocytes comprise more than 85% of all cells in normal livers, the cancerous liver presents with an increased number of infiltrating immune cells (Doumba, et al 2013; Guo, et al 2013), including dendrocytes (Butterfield 2004), monocytes/macrophages (Shirabe, et al 2012), CD4/8+ T cells (Guo et al 2013), neutrophils (Motomura, et al 2013), B cells (Chen, et al 2012) and mast cells (Ju, et al 2009). Other cells in the liver, such as endothelial cells (Sato and Mori 2011) or BM-MSCs (Garcia, et al 2011) may also be altered due to chronic inflammation or tumorigenesis.…”

Section: Part II Androgen/ar Signaling In Liver Cancermentioning

confidence: 99%

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

Lung¹,

Lai²,

Yeh³

et al. 2014

Endocrine-Related Cancer

141

114

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Summary Androgen/androgen receptor (AR) signaling plays important roles in normal liver function and in progression of liver diseases. In studies of non-cancerous liver diseases, AR knockout mouse models of liver disease have revealed that androgen/AR signaling suppresses the development of steatosis, virus-related hepatitis, and cirrhosis. In addition, studies have shown that targeting AR in bone marrow-derived mesenchymal stem cells (BM-MSCs) improves their self-renewal and migration potentials, thereby increasing the efficacy of BM-MSC transplantation as a way to control the progression of cirrhosis. Androgen/AR signaling is known to be involved in the initiation of carcinogen- or Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). However, studies have demonstrated that AR, rather than androgen, plays the dominant role in cancer initiation. Therefore, targeting AR might be an appropriate therapy for patients with early-stage HCC. In contrast, androgen/AR signaling has been shown to suppress metastasis of HCC in patients with late-stage disease. In addition, there is evidence that therapy comprising Sorafenib and agents that enhance the functional expression of AR may suppress the progression of late-stage HCC.

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Section: Part II Androgen/ar Signaling In Liver Cancermentioning

confidence: 99%

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

Lung¹,

Lai²,

Yeh³

et al. 2014

Endocrine-Related Cancer

141

114

View full text Add to dashboard Cite

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“…Accumulated evidence indicates that the progression of PLC is correlated closely with both inflammation[10] and immunocytes [11]. Recent studies suggest a potential prognostic role of the NLR in the treatment strategies of PLC, including hepatic resection,[12], [13], [14] liver transplantation,[15], [16], [17] radiofrequency ablation (RFA),[18], [19] and trans-arterial chemo-embolization (TACE)[20], [21].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-Analysis

et al. 2014

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The neutrophil-to-lymphocyte ratio (NLR) is a useful biomarker that reflects systemic inflammation responses. However, the prognostic value of the NLR in patients with primary liver cancer (PLC) remains controversial. We performed a meta-analysis of 26 studies (comprising 4,461 patients) to evaluate the association between the pre-treatment NLR and clinical outcomes of overall survival (OS) and disease-free survival (DFS) in patients with PLC. The correlation between NLR and tumor characteristics or other inflammation-related parameters was also assessed. Data were synthesized using the random-effects model of DerSimonian and Laird, and the hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was used to estimate effect size. Our analysis indicated that a high NLR predicted poor OS (HR, 2.102; 95% CI: 1.741–2.538) and DFS (HR, 2.474; 95% CI: 1.855–3.300) for PLC. A high NLR was associated with the presence of tumor vascular invasion (OR: 1.889, 95% CI: 1.487–2.400; p<0.001) and an elevated alpha-fetoprotein level (OR: 1.536; 95% CI: 1.152–2.048; p = 0.003). Thus, we conclude that a high NLR indicates a poor prognosis for patients with PLC and may also be predictive for PLC invasion and metastasis. Subgroup analysis suggested that the predictive role of NLR in cholangiocarcinoma is limited, and a further large study to confirm these findings is warranted.

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“…The review of the literature reveals attentiveness to the investigation of TILs in hepatic parenchyma, in primary tumor context -namely hepatocellular carcinoma (HCC) [3,[21][22][23][24][25][26][27][28][29][30][31][32] or in liver metastases (LM) [33][34][35]. Nevertheless, we have to highlight the fact that none of the published studies presented comparative data of CD4+ and CD8+ T lymphocytes in primary versus secondary liver tumors.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of CD4 and CD8 lymphocytes — evidences for different distribution in primary and secondary liver tumors

Giuşcă

Wierzbicki

Amălinei

et al. 2015

Folia Histochem Cytobiol.

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Introduction. The impact of tumor cells on tumor-infiltrating lymphocytes (TILs) in cancer developmentis not yet clarified. Our study analyzed the distribution and prognostic value of CD4+ and CD8+ T lymphocytes in hepatocellular carcinoma (HCC) and liver metastases (LM). Material and methods. Archival tissue specimens of 35 HCC and 39 LM patients were immunohistochemically processed. The number of intratumoral (IT) and peritumoral (PT) CD4+ and CD8+ T cells was quantitatively analyzed. Results.We noted large variances of T lymphocyte subpopulations. Similar number of CD4+ and CD8+ lymphocytes was present in HCC, whereas in LM the number of CD8+ cells was approximately two times higher than CD4+ lymphocytes. A significant prevalence of T cells in PT over IT areas was observed. The prognostic value was demonstrated only for PT CD8+ lymphocytes in LM, their reduced number being associated with shorter survival. Conclusions. The differences between proportions of T lymphocytes within tumor and its environment might be explained by proapoptotic effect of cancer cells on TILs.

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Associations Between Infiltrating Lymphocyte Subsets and Hepatocellular Carcinoma

Cited by 41 publications

References 19 publications

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis

Prognostic Significance of the Neutrophil-to-Lymphocyte Ratio in Primary Liver Cancer: A Meta-Analysis

Comparative analysis of CD4 and CD8 lymphocytes — evidences for different distribution in primary and secondary liver tumors

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