Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life

Alderete, Tanya L.; Autran, Chloe; Brekke, Benjamin; Knight, Rob; Bode, Lars; Goran, Michael I.; Fields, David A.

doi:10.3945/ajcn.115.115451

Cited by 177 publications

(219 citation statements)

References 46 publications

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“…Human milk oligosaccharides may promote slower ponderal growth and lower body fat during infancy by influencing the gut microbiome (37). Moreover, exclusive BF also fosters an anti-inflammatory cytokine milieu that may decrease future risk of obesity (38).…”

Section: Discussionmentioning

confidence: 99%

Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study

et al. 2018

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“…Analytical staff was blinded to the clinical metadata associated with each sample. HMO analysis was performed by high-performance liquid chromatography (HLPC) after fluorescent derivatisation with 2-aminobenzamide (2AB) as previously described 15 16. The non-HMO oligosaccharide raffinose was added to each milk sample as internal standard at the very beginning of sample preparation to allow for absolute quantification.…”

Section: Methodsmentioning

confidence: 99%

Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants

Autran

Kellman

Kim

et al. 2017

Gut

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“…HMOs are natural prebiotics that serve as an energy source for a diverse array of colonic bacteria and hence shape and sustain the infant gut microbiome. Although studies have shown that the composition, diversity, and abundance of specific HMOs is associated with infant growth and adiposity, 158 the effect of maternal obesity on the diversity of HMOs in milk is poorly understood.…”

Section: Alterations In Neonatal Nutrition and Infant Microbiomementioning

confidence: 99%

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Catalano

Shankar

2017

BMJ

847

749

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Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased. Postpartum, obese women have an increased risk of venous thromboembolism, depression, and difficulty with breast feeding. Because 50-60% of overweight or obese women gain more than recommended by Institute of Medicine gestational weight guidelines, postpartum weight retention increases future cardiometabolic risks and prepregnancy obesity in subsequent pregnancies. Neonates of obese women have increased body fat at birth, which increases the risk of childhood obesity. Although there is no unifying mechanism responsible for the adverse perinatal outcomes associated with maternal obesity, on the basis of the available data, increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction. We will review the pathophysiology underlying these data and try to shed light on the specific underlying mechanisms.

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Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life

Abstract: These findings support the hypothesis that differences in HMO composition in mother's milk are associated with infant growth and body composition. This trial was registered at clinicaltrials.gov as NCT02535637.

Cited by 177 publications

References 46 publications

Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study

Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study

Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

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