Associations between high-risk alcohol consumption and sarcopenia among postmenopausal women

Kwon, Yu‐Jin; Lim, Hyoung Ji; Lee, Yong Jae; Lee, Hye Sun; Linton, John A.; Lee, Jae Woo; Kang, Hee-Taik

doi:10.1097/gme.0000000000000879

Cited by 24 publications

(21 citation statements)

References 33 publications

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“…In this study, alcohol drinking was inversely related to low HGS in both sexes after adjusting for age (Model 1), and among women, drinking alcohol was still inversely associated with low HGS after adjusting for variables that were statistically significant in Model 1 (Model 2). Although excessive drinking was known to be associated with sarcopenia in Korean postmenopausal women [20], light to moderate alcohol drinking has also been reported to be effective in preventing muscle mass reduction [21]. Similar to our findings, in the large cohort study conducted in Europe, it was also reported that current alcohol drinking was associated with an increase in HGS.…”

Section: Discussionsupporting

confidence: 90%

“…This difference is presumed to be due to differences in the classification criteria or socioeconomic environments between the studies. Although the impact of education on HGS is unclear, the subjects with higher educational level seemed to be more conscious of the importance of physical activity in maintaining health [20]. In contrast, people with lower educational level showed lower physical activity [24].…”

Section: Discussionmentioning

confidence: 99%

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Risk factors associated with low handgrip strength in the older Korean population

2019

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Hand grip strength (HGS) is a means to assess health status and physical abilities indirectly. Various factors are known to be related to HGS, but data on the factors influencing HGS in the Korean population are lacking. Recently, the Korea National Health and Nutrition Examination Survey (KNHANES) conducted by the Korea Centers for Disease Control and Prevention surveyed social status, nutrition, physical status, and other medical history including HGS. This study aimed to investigate the social, physical, and individual health behavior factors associated with low HGS in the elderly Korean population. This population-based cross-sectional study was based on the 2014–2016 KNHANES. Community-dwelling Korean elderly (aged ≥65 years) were included in this survey. The relationship between HGS and socioeconomic status, nutrition, exercise, and other clinical characteristics were analyzed using multivariate logistic regression. The sample size was 3,634 (weighted: 6,006,406). Elderly men and women with low HGS showed lower body mass index, reduced physical activity and lower education level. Among elderly men, excessive carbohydrate and inadequate protein intake were observed in the low HGS group. Meanwhile, older women who did not drink alcohol and had diabetes were at higher risk of low HGS. In conclusion, various physical, nutritional, socioeconomic and comorbidity statuses were seemed to be the factors associated with HGS in Korean elderly. However, further cohort or case-control study will be necessary to determine the causal relationship of those factors and HGS.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Risk factors associated with low handgrip strength in the older Korean population

2019

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“…In animal studies, ethanol impaired skeletal muscle protein synthesis and increased muscle autophagy [13,15,39]. Unfortunately, the few studies that have examined the association between alcohol and muscle mass in humans have not yielded consistent findings [17,18]. A recent meta-analysis of a population of non-cancer patients did not support alcohol consumption as a risk factor for sarcopenia [16].…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, alcohol consumption inhibited the synthesis of skeletal muscle proteins in rats. In humans, this relationship remains controversial, although a negative relationship has been reported between alcohol consumption and sarcopenia in the general population [16,17,18]. Moreover, little is known about the potential interacting effects of alcohol consumption and protein intake on sarcopenia [19].…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption Reduces the Beneficial Influence of Protein Intake on Muscle Mass in Middle-Aged Korean Adults: A 12-Year Community-Based Prospective Cohort Study

Joung

2019

Nutrients

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The influence of alcohol consumption on the association of protein intake with muscle mass was assessed using data from the Korean Genome and Epidemiology Study. Dietary protein intakes of 4412 middle-aged participants with normal baseline muscle mass were assessed using a semi-quantitative Food Frequency Questionnaire, and baseline alcohol consumption data (e.g., frequency and amount) were collected using a structured questionnaire. The skeletal muscle mass index (SMI), defined as the weight-adjusted skeletal muscle mass, was measured using multi-frequency bioelectrical impedance analyses every 2 years until the study endpoint. Low muscle mass was defined as a SMI <2 standard deviations below the sex-specific normal mean for a young reference group. During a 12-year follow-up, 395 subjects developed a low SMI. After multivariate adjustments, high protein intake (≥1.2 g/kg body weight (BW)) was shown to reduce the risk of low SMI development in both men (hazard ratio (HR): 0.24; 95% confidence interval (CI): 0.12, 0.51; p for trend < 0.001) and women (HR: 0.29; 95% CI: 0.16, 0.53; p for trend < 0.001), compared with low protein intake (<0.8 g/kg BW). Alcohol consumption attenuated the protective influence of protein intake against low SMI development in women (HR: 0.64; 95% CI: 0.18, 2.25; p for trend = 0.478). Among the total subjects, heavy drinkers with high protein intake were not significantly associated with the development of a low SMI (HR: 0.20; 95% CI: 0.03, 1.50; p = 0.117). Additional research should clarify the dose-response effects of alcohol consumption on muscle mass relative to daily protein intake.

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“…Moreover, having protein intakes above the RDI did not contribute to the multivariable model for low‐rALM or combined low‐rALM and low‐BMD and perhaps this is because only about one‐tenth of our participants had protein intakes below the RDI. There is also extant evidence that fish oil‐derived omega‐3 fatty acids slow the decline in muscle mass and function in older adults [36], and that low vitamin D [37], cigarette smoking [38] and high alcohol consumption [39] exacerbate skeletal muscle deterioration. What is unclear if these factors operate directly or are indicative of lifestyle behaviours or of social or economic determinants of health.…”

Section: Discussionmentioning

confidence: 99%

Pretiree lifestyles in relation to musculoskeletal health: cross‐sectional data from the Geelong Osteoporosis Study

Pasco

Holloway‐Kew

Hyde

et al. 2018

JCSM Clinical Reports

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Aims What happens in the early-elderly 'pretiree' period potentially influences the divergent paths of healthy or unhealthy ageing. In this cross-sectional study, we aimed to profile musculoskeletal health and lifestyle behaviours for men and women in their late-fifties and sixties. Methods and resultsFor 482 participants from the Geelong Osteoporosis Study, we measured DXA-derived relative appendicular lean mass (rALM), bone mineral density (BMD) at the femoral neck and percentage body fat mass (%BF). Low-rALM and low-BMD referred to sex-specific T-scores<-1.0. Associations between exposures and low-rALM and/or low-BMD were explored using multivariable logistic regression. Three-quarters of participants had high %BF, 98(20.3%) had low-rALM, 202(41.9%) had low-BMD and 63(13.1%) had both low-rALM and low-BMD. Eight-two (17.0%) were very active and one-third participated in sports/recreational activities. Most [n=416(87.8%)] met the recommended daily intake (RDI) for protein; only 119(25.1%) met the RDI for calcium. Less than 10% smoked and one-third exceeded recommended alcohol intakes. Independent of age, weight and sex, greater %BF and sedentary behaviour increased the likelihood of low-rALM; high-alcohol consumption increased the likelihood of low-BMD; and greater %BF increased the likelihood of low-rALM and low-BMD combined. Conclusions One-half of participants had rALM and BMD in the normal range. Only a few were involved in resistance-training or weight-bearing exercise, despite having the capacity to be physically active. As sedentary lifestyles, excessive adiposity and high alcohol use were associated with low-rALM and/or low-BMD, we propose that these adverse factors be potential targets among pretirees to minimise their risk of entering old age with poor musculoskeletal health.

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Associations between high-risk alcohol consumption and sarcopenia among postmenopausal women

Cited by 24 publications

References 33 publications

Risk factors associated with low handgrip strength in the older Korean population

Risk factors associated with low handgrip strength in the older Korean population

Alcohol Consumption Reduces the Beneficial Influence of Protein Intake on Muscle Mass in Middle-Aged Korean Adults: A 12-Year Community-Based Prospective Cohort Study

Pretiree lifestyles in relation to musculoskeletal health: cross‐sectional data from the Geelong Osteoporosis Study

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