Associations between high birth weight, being large for gestational age, and high blood pressure among adolescents: a cross-sectional study

Kučienė, Renata; Dulskienė, Virginija; Medžionienė, Jūratė

doi:10.1007/s00394-016-1372-0

Cited by 43 publications

(40 citation statements)

References 24 publications

(29 reference statements)

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“…The novelty of our findings is specifically tied to the association with hypertension. At the population level, this association remained significant after adjustment for other factors related to elevated blood pressure and hypertension: birth weight (reviewed in 54,290 ), small 291 or large 292 birth weight for gestational age, preterm birth 291,293 , and socioeconomic status. 294 When we restricted the composite outcome to CVD endpoints (thereby excluding CVD risk factors such as hypertension and T2D), the strength of the association between intrauterine diabetes exposure and CVD incidence was reduced for both GDM and preexisting diabetes exposures, but remained statistically significant (Table 4.2 and section 4.3.4).…”

Section: Intrauterine Diabetes Exposure As a Novel Risk Factor For Cvdmentioning

confidence: 96%

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

et al. 2017

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Section: Intrauterine Diabetes Exposure As a Novel Risk Factor For Cvdmentioning

confidence: 96%

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

et al. 2017

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“…Maternal preeclampsia is associated with increased SBP and diastolic blood pressure in the offspring already in childhood, and being born SGA after a preeclamptic pregnancy increased the risk of higher SBP (OR [95% CI] 8.7 [1.3–57]) [66, 67]. Being born LGA or with high birth weight increased the risk of elevated blood pressure in adolescents [68]. In 7-year-old LGA-born children, the risk of hypertension associated with the lack of catch-down growth (and subsequent obesity) [16].…”

Section: Introductionmentioning

confidence: 99%

Birth Size as a Determinant of Cardiometabolic Risk Factors in Children

2020

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The association between birth size and cardiometabolic disease risk may be U-shaped. Being born small for gestational age (SGA) has a definitive association with later cardiovascular risk, but the impact of being born large for gestational age (LGA) on cardiometabolic health is more controversial. In addition to birth size, early postnatal growth pattern and later weight gain affect cardiometabolic risk in adulthood. Most SGA-born children have catch-up and LGA-born children have catch-down growth during the first years of life. The extent of this early compensatory growth may contribute to the adverse health outcomes. Both SGA-and LGAborn children are at an increased risk for overweight and obesity. This may have a long-term impact on cardiometabolic health as overweight tends to track to adulthood. Other cardiometabolic risk factors, including alterations in glucose metabolism, dyslipidemia, hypertension, and lowgrade inflammation are associated with birth weight. Many of these risk factors are related to overweight or adverse fat distribution. Since later cardiometabolic risk is often mediated by early growth pattern and later overweight in SGA and LGA children, it is important to focus on staying normal weight throughout life. Hence, effective interventions to reduce cardiometabolic risk in LGA and SGA children should be developed.

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“…Infants born large for gestational age (LGA) have increased risks of adverse perinatal outcomes including birth asphyxia, shoulder dystocia, and neonatal morbidity . LGA offspring also face an excess risk of infant death, future obesity, hypertension and type 2 diabetes . LGA is usually defined as birthweight above the 90th centile for gestational age and sex, although the 97th centile may be a more appropriate cut‐off as it better identifies infants at risk .…”

Section: Introductionmentioning

confidence: 99%

Prediction of large‐for‐gestational‐age infants in pregnancies complicated by obesity: A population‐based cohort study

Åmark

Westgren

Persson

2019

Acta Obstet Gynecol Scand

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Abbreviations: AUC, area under curve; β-hCG, β human chorionic gonadotropin; BMI, body mass index; CI, confidence interval; LGA, large for gestational age; PAPP-A, pregnancy-associated plasma protein A. AbstractIntroduction: Infants born large for gestational age (LGA) have increased risks of adverse perinatal outcomes. Maternal obesity, defined as body mass index (BMI) ≥30 kg/m 2 , is one of the most prevalent risk factors for LGA and the proportion of pregnancies complicated by obesity is increasing. Early identification of women with BMI ≥30 kg/m 2 at increased risk of giving birth to an LGA infant may open possibilities for prevention, aiming at decreasing the incidence of LGA. Material and methods:A population-based cohort study using information from the first-trimester screening database, which was cross-linked with the Swedish Medical Birth Register. The database included 139 277 full-term singletons without fetal anomalies born between 2006 and 2015 to mothers without prepregnancy diabetes.Of these, 9.1% (n = 12 704) were infants of mothers with BMI ≥30 kg/m 2 . For all women with BMI ≥30 kg/m 2 , a prediction model for LGA to be used in early pregnancy was constructed based on information on biochemical markers and maternal characteristics. A similar model, as well as a prepregnancy prediction model, were constructed for parous women with BMI ≥30 kg/m 2 . In parous women, data from the previous pregnancy were also used. Receiver operating characteristic curve and area under curve (AUC) were calculated. Results:The predictive models for LGA in parous women with BMI ≥30 kg/m 2 prepregnancy and in early pregnancy had AUCs of 0.80 (95% CI 0.78-0.82) and 0.81 (95% CI 0.79-0.82), respectively. For all women with BMI ≥30 kg/m 2 , the prediction of LGA in early pregnancy had an AUC of 0.66 (95% CI 0.64-0.67). Conclusions:Performance of the prepregnancy and early pregnancy prediction models for LGA in parous women with BMI ≥30 kg/m 2 was good. The predictive capacity was largely driven by previous child's birthweight. First-trimester measurements of fetal size did not improve the predictive capacity in parous women. Predictions ofLGA in all women with BMI ≥30 kg/m 2 in early pregnancy, without taking previous child's birthweight into account, remain difficult. K E Y W O R D Slarge for gestational age, maternal obesity, prediction, pregnancy-associated plasma protein A

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Associations between high birth weight, being large for gestational age, and high blood pressure among adolescents: a cross-sectional study

Cited by 43 publications

References 24 publications

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

Intensive gestational glycemic management and childhood obesity: a systematic review and meta-analysis

Birth Size as a Determinant of Cardiometabolic Risk Factors in Children

Prediction of large‐for‐gestational‐age infants in pregnancies complicated by obesity: A population‐based cohort study

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