Associations between HbA1c-derived estimated average glucose and fasting plasma glucose in patients with normal and abnormal hemoglobin patterns

Sriwimol, Wilaiwan; Choosongsang, Phattanapong; Petkliang, Warakorn; Treerut, Pittaya

doi:10.1080/00365513.2022.2040051

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…In this case, HbA1c decreased from 10.9% to 6.8% in just 3 months. The association between HbA1c levels and estimated average blood glucose levels (eAG) has been previously reported [18], with the estimated average glucose (eAG) decreasing from 265 to 148 mg/dL in this instance [19]. Regarding his past history, his weight significantly increased during his 30s to 50s.…”

Section: Discussionsupporting

confidence: 62%

Improvement of HbA1c, Weight and Fatty Liver by Short Treatment of Imeglimin (Twymeeg)

Kawata,

Bando,

Kato

et al. 2024

Asp Biomed Clin Case Rep

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The patient is a 55-year-old male with type 2 diabetes (T2D). In his 20s, 30s, and 50s, his body weight was 80 kg, 95 kg, and 90 kg, respectively. HbA1c was 10.9% in March 2023, and he was prescribed imeglimin (Twymeeg) as an oral hypoglycemic agent (OHA). HbA1c decreased to 9.3%, 7.2%, and 6.8% within just 3 months. His body weight also decreased from 86 kg to 82 kg during this period. Liver function tests showed improvement between March and May 2023, with AST decreasing from 54 to 24 U/L, ALT from 121 to 28 U/L, and GGT from 45 to 18 U/L, respectively. This suggests an improvement in fatty liver.

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Section: Discussionsupporting

confidence: 62%

Improvement of HbA1c, Weight and Fatty Liver by Short Treatment of Imeglimin (Twymeeg)

Kawata,

Bando,

Kato

et al. 2024

Asp Biomed Clin Case Rep

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“…The HbA1c‐derived eAG estimates average glucose levels, which could inform individuals with hyperglycemia about their glycemic control 9 . Some studies reported that the correlation between HbA1c‐derived eAG and FBG depended on the level of glycemic control 20,21 . Kim et al 21 demonstrated that the correlation between eAG and FBG decreased in well‐controlled diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…9 Some studies reported that the correlation between HbA1c-derived eAG and FBG depended on the level of glycemic control. 20,21 Kim et al 21 demonstrated that the correlation between eAG and FBG decreased in well-controlled diabetic patients. They also demonstrated that large differences between eAG and FBG in well-controlled diabetic patients might reflect the higher contribution of postprandial glucose in these patients than in poorly controlled diabetics, whereas the small differences between eAG and FBG in poorly controlled patients might reflect the higher contribution of FBG in these patients than in well-controlled patients.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of the estimated average glucose/fasting blood glucose ratio for pancreatic β‐cell function assessment in hyperglycemia during health checkups

Nah

Cho

Park

et al. 2022

Clinical Laboratory Analysis

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Background Type 2 diabetes (T2DM) is a disease marked by inadequate insulin secretion by pancreatic beta‐cell function (BCF) failure and insulin resistance (IR). Assessing and managing the BCF and IR should be started early to prevent or delay the progression of the disease. The aim of this study was to determine the usefulness of the estimated average glucose (eAG)/fasting blood glucose (FBG) ratio for pancreatic BCF in hyperglycemia. Methods This cross‐sectional study consecutively selected 10,594 subjects who underwent a health checkup at 16 health checkup centers in 13 Korean cities between 2019 and 2021. The subjects consisted of 3003 patients with normoglycemia, 3413 with impaired fasting glucose and 4178 with T2DM. The eAG was calculated using Nathan's regression equation. BCF and IR were estimated by the homeostasis model assessment (HOMA)‐β and HOMA‐IR, respectively. Multivariate (adjusted) regression analysis was performed to evaluate the association between the eAG/FBG ratio and HOMA. Results The median values among FBG groups for the eAG/FBG ratio, HOMA‐β, ‐IR and insulin differed significantly (p < 0.001). The second‐, third‐ and fourth‐quartile groups of the eAG/FBG ratio had positive higher correlation coefficients [9.533, 10.080 and 12.021, respectively (all p < 0.001)] for HOMA‐β than the first quartile group, and higher negative coefficients for HOMA‐IR [−0.696, −0.727 and −0.598, respectively (all p = 0.001)]. Conclusion The eAG/FBG ratio was significantly correlated with both HOMA‐β and ‐IR, which suggests that eAG/FBG ratio reveals BCF and IR in hyperglycemia. Measurement of this ratio could be useful for monitoring BCF and IR in prediabetes and T2DM.

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“…The American Diabetes Association and the American Association of Clinical Chemists have advocated the estimation of average glucose from HbA1c with the use of Nathan's equation to give glucose values in mg/dL. This unit is relatable to the patients (Kariyawasan et al, 2021, Sriwimol et al, 2022. In a resource-poor setting like Nigeria, with a growing burden of diabetes and insufficient coverage of health insurance scheme, patients are scheduled to do a pre-appointment onetime FPG to assess the adequacy of glycaemic control to aid the continued use or titration of hypoglycaemic agents (Balogun et al, 2020).…”

Section: Open Accessmentioning

confidence: 99%

Correlation of estimated average glucose with single point glucose values in patients attending a clinical laboratory facility in South-Western Nigeria: a retrospective study

Bamidele,

Okoduwa,

Olasehinde

et al. 2023

Nig. J. Biochem. Mol. Biol.

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Regular monitoring of glycaemic levels in patients with diabetes mellitus forms a major fulcrum for ensuring a desirable treatment outcome and a good quality of life in affected individuals. Glycated haemoglobin (HbA1c) measurement is a common and dependableoption for determining long-term glycaemic control. Unfortunately, it is relatively expensive and not readily available in most low- ncome settings. Measuring fasting plasma glucose (FPG) is the cheaper alternative if it correlates with HbA1c. A retrospective study into clinical records to identify all patients who had HbA1c and FPG was conducted on the same day between January 2021 and July 2022. Estimated average glucose was calculated from the HbA1c and the values were correlated with the FPG. Factors predicting values for HbA1c were also determined. The results obtained showed that a total of 315 patients had clinical records required for the study, 147(46.7%) males and 168 (53.3%) females. They were grouped into diabetic (n=111, with median FPG of 155 mg/dL), impaired fasting glucose (n=67, with median FPG of 108 mg/dL) and non-diabetic (n=137, with median FPG of 92 mg/dL) participants. The estimated average glucose for the three groups was 160 mg/dL, 117 mg/dL and 112 mg/dL, respectively. The FPG of the diabetic group showed a moderate correlation with the estimated average glucose (0.630 and a p-value < 0.001), and factors which predicted a high HbA1c were increasing age, FPG and the presence of diabetes mellitus. This data further encourages the continued use of FPG in monitoring glycaemic control in diabetic patients, especially in resource-poor locations where HbA1c is either too expensive or unavailable.

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Associations between HbA1c-derived estimated average glucose and fasting plasma glucose in patients with normal and abnormal hemoglobin patterns

Cited by 6 publications

References 28 publications

Improvement of HbA1c, Weight and Fatty Liver by Short Treatment of Imeglimin (Twymeeg)

Improvement of HbA1c, Weight and Fatty Liver by Short Treatment of Imeglimin (Twymeeg)

The usefulness of the estimated average glucose/fasting blood glucose ratio for pancreatic β‐cell function assessment in hyperglycemia during health checkups

Correlation of estimated average glucose with single point glucose values in patients attending a clinical laboratory facility in South-Western Nigeria: a retrospective study

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