Associations between gut microbiota and thyroidal function status in Chinese patients with Graves’ disease

Chen, J.; Wang, W.; Guo, Zhen; Huang, Shuai; Lei, Hongyi; Zhang, Pu; Lü, Bin; Shao, Jianghua; Gu, Pengyu

doi:10.1007/s40618-021-01507-6

Cited by 24 publications

(52 citation statements)

References 61 publications

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“…Our study found significantly high levels of Prevotella_9 in GD patients, which is consistent with previous reports in GD patients (Ishaq et al, 2018), while decreased levels of Prevotella_9 have been found in HT patients (Zhao et al, 2018). Besides, our study showed that the abundance of the family Veillonellaceae in patients with GD was increased, which is consistent with the previous studies (Yan et al, 2020;Chen et al, 2021). The Veillonella genus is normal flora of the mouth, gastrointestinal tract, and vagina.…”

Section: Discussionsupporting

confidence: 92%

Alterations of Gut Microbiota in Patients With Graves’ Disease

Chang

Lin

Chen

et al. 2021

Front. Cell. Infect. Microbiol.

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Graves’ disease (GD) is a systemic autoimmune disease characterized by hyperthyroidism. Evidence suggests that alterations to the gut microbiota may be involved in the development of autoimmune disorders. The aim of this study was to characterize the composition of gut microbiota in GD patients. Fecal samples were collected from 55 GD patients and 48 healthy controls. Using 16S rRNA gene amplification and sequencing, the overall bacterial richness and diversity were found to be similar between GD patients and healthy controls. However, principal coordinate analysis and partial least squares-discriminant analysis showed that the overall gut microbiota composition was significantly different (ANOSIM; p < 0.001). The linear discriminant analysis effect size revealed that Firmicutes phylum decreased in GD patients, with a corresponding increase in Bacteroidetes phylum compared to healthy controls. In addition, the families Prevotellaceae, and Veillonellaceae and the genus Prevotella_9 were closely associated with GD patients, while the families Lachnospiraceae and Ruminococcaceae and the genera Faecalibacterium, Lachnospira, and Lachnospiraceae NK4A136 were associated with healthy controls. Metagenomic profiles analysis yielded 22 statistically significant bacterial taxa: 18 taxa were increased and 4 taxa were decreased. Key bacterial taxa with different abundances between the two groups were strongly correlated with GD-associated clinical parameters using Spearman’s correlation analysis. Importantly, the discriminant model based on predominant microbiota could effectively distinguish GD patients from healthy controls (AUC = 0.825). Thus, the gut microbiota composition between GD patients and healthy controls is significantly difference, indicating that gut microbiota may play a role in the pathogenesis of GD. Further studies are needed to fully elucidate the role of gut microbiota in the development of GD.

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Section: Discussionsupporting

confidence: 92%

Alterations of Gut Microbiota in Patients With Graves’ Disease

Chang

Lin

Chen

et al. 2021

Front. Cell. Infect. Microbiol.

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“…In addition, the current results revealed the correlation between the clinical parameters of AITD, such as TRAb or TPOAb and the certain microbiota (22,27,28). For example, Chen et al (29) found that the proportion of Synergistetes was negatively correlated with TRAb, and Jiang et al (30) found that Lactobacillus was positively correlated with TRAb. At the phylum level, Yang et al (31) found a higher Firmicutes/Bacteroidetes ratio in GD patients than in the control group, which may be relevant to inflammation disease, whereas Hanaa et al (32) found that the ratio was significantly decreased in patients with AITD.…”

Section: Introductionsupporting

confidence: 52%

“…For example, Chen et al. ( 29 ) found that the proportion of Synergistetes was negatively correlated with TRAb, and Jiang et al. ( 30 ) found that Lactobacillus was positively correlated with TRAb.…”

Section: Introductionmentioning

confidence: 99%

Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

et al. 2021

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BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.ResultsThe meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.ConclusionsThis meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.Systematic Review RegistrationPROSPERO, identifier CRD42021251557.

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“…NC: results are not consistent between studies. Changet al, 2021;Chen et al, 2021;Jiang et al, 2021). However, other results across these studies lack consistency.…”

Section: Gut Microbiota In Gd Patientsmentioning

confidence: 92%

“…In three studies, Lactobacillus increased in GD patients (Yan et al, 2020;Chen et al, 2021;Jiang et al, 2021). Interestingly, the TRAb level was correlated positively with Lactobacillus, and the abundance of Lactobacillus decreased after oral methimazole (MMI) treatment (Chen et al, 2021).…”

Section: Gut Microbiota In Gd Patientsmentioning

confidence: 99%

The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy

Hou

Tang²,

Chen³

et al. 2021

Front. Cell. Infect. Microbiol.

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Graves‘ disease (GD) is a clinical syndrome with an enlarged and overactive thyroid gland, an accelerated heart rate, Graves’ orbitopathy (GO), and pretibial myxedema (PTM). GO is the most common extrathyroidal complication of GD. GD/GO has a significant negative impact on the quality of life. GD is the most common systemic autoimmune disorder, mediated by autoantibodies to the thyroid-stimulating hormone receptor (TSHR). It is generally accepted that GD/GO results from complex interactions between genetic and environmental factors that lead to the loss of immune tolerance to thyroid antigens. However, the exact mechanism is still elusive. Systematic investigations into GD/GO animal models and clinical patients have provided important new insight into these disorders during the past 4 years. These studies suggested that gut microbiota may play an essential role in the pathogenesis of GD/GO. Antibiotic vancomycin can reduce disease severity, but fecal material transfer (FMT) from GD/GO patients exaggerates the disease in GD/GO mouse models. There are significant differences in microbiota composition between GD/GO patients and healthy controls. Lactobacillus, Prevotella, and Veillonella often increase in GD patients. The commonly used therapeutic agents for GD/GO can also affect the gut microbiota. Antigenic mimicry and the imbalance of T helper 17 cells (Th17)/regulatory T cells (Tregs) are the primary mechanisms proposed for dysbiosis in GD/GO. Interventions including antibiotics, probiotics, and diet modification that modulate the gut microbiota have been actively investigated in preclinical models and, to some extent, in clinical settings, such as probiotics (Bifidobacterium longum) and selenium supplements. Future studies will reveal molecular pathways linking gut and thyroid functions and how they impact orbital autoimmunity. Microbiota-targeting therapeutics will likely be an essential strategy in managing GD/GO in the coming years.

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Associations between gut microbiota and thyroidal function status in Chinese patients with Graves’ disease

Cited by 24 publications

References 61 publications

Alterations of Gut Microbiota in Patients With Graves’ Disease

Alterations of Gut Microbiota in Patients With Graves’ Disease

Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy

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