Associations between gene polymorphisms, breeding values, and glucose tolerance test parameters in German Holstein sires

Čítek, J.; Hanusová, L.; Brzáková, Michaela; Večerek, Libor; Panicke, L.; Lískovcová, Lucie

doi:10.17221/8/2017-cjas

Cited by 4 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, when the effects of alleles are evaluated, A is advantageous but not significantly so ( Table 2 ). This result is generally in agreement with previous findings and confirms our previous finding in German Holsteins regarding the trend of increasing frequency of the alanine variant [ 32 , 33 ].…”

Section: Resultssupporting

confidence: 93%

Gene polymorphisms influencing yield, composition and technological properties of milk from Czech Simmental and Holstein cows

Čítek¹,

Brzáková

Hanusová

et al. 2021

Anim Biosci

View full text Add to dashboard Cite

Objective: The aim of the study was to evaluate the influence of polymorphic loci and other factors on milk performance and the technological properties of milk.Methods: The analysis was performed on Simmental and Holstein cows in field conditions (n = 748). Milk yield in kg, fat and protein percentage and yield were evaluated. Technological properties were evaluated by milk fermentation ability, renneting, and an alcohol test. Polymorphisms in the acyl-CoA diacylgycerol transferase 1 (DGAT1), leptin (LEP), fatty acid synthase (FASN), stearoyl CoA desaturase 1 (SCD1), casein beta (CSN2), casein kappa (CSN3), and lactoglobulin beta genes were genotyped, and association analysis was performed.Results: The DGAT1 AA genotype was associated with higher milk, protein and fat yields (p<0.05). The MM genotype in the LEP gene was associated with a lower protein percentage and the W allele with a higher protein percentage (p<0.05). In cows with the FASN GG genotype, the protein percentage was higher, but the A allele was associated with higher milk, protein and fat yields than the G allele. The TT genotype in SCD1 was associated with the lowest milk, protein and fat yields and with the highest milk protein percentage (p<0.01). The T allele had higher values than the C allele (p<0.05) except for fat percentage. The genotype CSN3 AA was associated with a significantly heightened milk yield; BB was associated with a high protein percentage. The effect of the alleles on the technological properties was not significant. The CSN3 BB genotype was associated with the best alcohol test (p<0.01), and the renneting order was inverse. Milk from cows with the CSN2 A1A1 genotype was best in the milk fermentation ability. CSN3 significantly affected the technological properties.Conclusion: The findings revealed the potential of some polymorphic loci for use in dairy cattle breeding and for the management of milk quality. In field research, the pivotal role of farms in milk yield, composition and technological properties was confirmed.

show abstract

Section: Resultssupporting

confidence: 93%

Gene polymorphisms influencing yield, composition and technological properties of milk from Czech Simmental and Holstein cows

Čítek¹,

Brzáková

Hanusová

et al. 2021

Anim Biosci

View full text Add to dashboard Cite

show abstract

“…Somewhat surprisingly, the DGAT1 polymorphism did not show such an influence; the AA genotype was superior to AK only in C22:0 ( p < 0.05) and AK over AA in C20:4n-3 ( p < 0.01). The influence of DGAT1 gene polymorphisms on the fat content in cow´s milk has been confirmed repeatedly [ 18 , 19 , 28 ]. Other authors found that polymorphisms strongly influenced MCFAs and UFAs in DGAT1 and SCD1 .…”

Section: Resultsmentioning

confidence: 95%

“…The authors suggest that some of them could be useful as a marker selection for FA composition in milk. Specifically, DGAT1 (acyl-CoA diacylglycerol transferase 1) and SCD1 polymorphisms have recently become the focus [ 6 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Samková

Čítek

Brzáková

et al. 2021

Animals

View full text Add to dashboard Cite

This study aimed to analyze the factors affecting the fatty acid (FA) profile in cow’s milk. The effects of a farm, lactation parity and stage, breed and polymorphisms in the AGPAT6, DGAT1, LEP, FASN and SCD1 genes were evaluated. A total of 196 Holstein cows, 226 Simmental cows and seven crosses were sampled 751 times. The cows were kept at five farms and were in the first up to the sixth lactation, and 49 individual FAs and 11 groups were analyzed. The farm significantly affected the proportion of all FAs except for C16:1n-7c and isoC14:0. Additionally, the lactation stage was significant for most FAs, and the opposite was true for lactation parity. The effect of the breed was negligible. For the gene polymorphisms, the SCD1 TT genotype exceeded the CC in C10:0, C12:0, C14:0, C16:1n-7c and C18:2, and the opposite was true for C10:1, C12:1, C14:1n-5c, isoC17:0, C16:1 and C18:1, i.e., the TT genotype was higher for saturated FAs, and the CT genotype was higher for monounsaturated FAs. The results hint at the intermediary heredity of the SCD1 gene. The FASN gene was strongly associated with four FAs and branched-chain FAs, and genotype AG was better than GG. LEP was significant for five individual FAs and branched-chain FAs. The differences in FA composition among genotypes were rather small, which could lead to overestimation of the effect and needs to be considered in the next research.

show abstract

“…Park et al investigated the genetic architecture of these traits and reported that the traits had moderate and high heritability estimates [ 22 ]. The previous studies on the association between genotypes and BVs considered BVs estimates of all additive genetic effects without the other environmental effects—and no environmental factor was included in the model [ 23 , 24 ]. Therefore, we followed their approaches in the association analysis for MAE SNPs.…”

Section: Methodsmentioning

confidence: 99%

Identification of Monoallelically Expressed Genes Associated with Economic Traits in Hanwoo (Korean Native Cattle)

Lim

Kim

Choi

et al. 2021

Animals

View full text Add to dashboard Cite

Hanwoo, an indigenous Korean cattle breed, has been genetically improved by selecting superior sires called Korean-proven bulls. However, cows still contribute half of the genetic stock of their offspring, and allelic-specific expressed genes have potential, as selective targets of cows, to enhance genetic gain. The aim of this study is to identify genes that have MAEs based on both the genome and transcriptome and to estimate their effects on breeding values (BVs) for economically important traits in Hanwoo. We generated resequencing data for the parents and RNA-sequencing data for the muscle, fat, and brain tissues of the offspring. A total of 3801 heterozygous single nucleotide polymorphisms (SNPs) in offspring were identified and they were located in 1569 genes. Only 14 genes showed MAE (seven expressing maternal alleles and seven expressing paternal alleles). Tissue-specific MAE was observed, and LANCL1 showed maternal allele expression across all tissues. MAE genes were enriched for the biological process of cell death and angiogenesis, which included ACKR3 and PDCL3 genes, whose SNPs were significantly associated with BVs of lean meat production-related traits, such as weight at 12 months of age, carcass weight, and loin eye area. In the current study, monoallelically expressed genes were identified in various adult tissues and these genes were associated with genetic capacity in Hanwoo.

show abstract

Associations between gene polymorphisms, breeding values, and glucose tolerance test parameters in German Holstein sires

Cited by 4 publications

References 24 publications

Gene polymorphisms influencing yield, composition and technological properties of milk from Czech Simmental and Holstein cows

Gene polymorphisms influencing yield, composition and technological properties of milk from Czech Simmental and Holstein cows

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Identification of Monoallelically Expressed Genes Associated with Economic Traits in Hanwoo (Korean Native Cattle)

Contact Info

Product

Resources

About