Associations between gender, age and waist circumference

Stevens, June; Katz, Eva G.; Huxley, Rachel R.

doi:10.14341/2071-8713-5194

Cited by 30 publications

(37 citation statements)

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“…The differences we see in men and women could be associated with fat distribution/composition and the biochemical consequences thereof, since fat distribution is known to differ between women and men (32). Unfortunately, we did not collect measures of waist circumference or waist to hip ratio and cannot explore this hypothesis further.…”

Section: Discussionmentioning

confidence: 95%

Association between body mass index and anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis: Results from a population‐based case–control study

Wesley¹,

Bengtsson²,

Elkan³

et al. 2012

Arthritis Care & Research

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Objective. Being overweight or obese is associated with many chronic diseases, but previous studies of the association with rheumatoid arthritis (RA) have shown inconsistent results. The aim of this study was to investigate the association between body mass index (BMI) and the risk of developing the 2 main subtypes of RA. Methods. At inclusion, cases and controls answered questions about their weight and height and donated blood samples. The presence of antibodies to citrullinated protein antigens (ACPAs) was analyzed among 2,748 cases and 3,444 controls (28% men). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using conditional logistic regression. Results. Compared to those with normal weight (BMI <25 kg/m 2 ), the adjusted overall OR for developing ACPA-negative RA was 1.1 (95% CI 0.9 -1.3) for overweight individuals (BMI >25 to <30 kg/m 2 ) and 1.4 (95% CI 1.1-1.9) for obese individuals (BMI >30 kg/m 2 ). When stratified by sex, the OR for ACPA-negative RA for obese women was 1.6 (95% CI 1.2-2.2), and there was no association between obesity and ACPA-negative RA in men (OR 1.1, 95% CI 0.6 -1.8). In obese men compared to men with normal weight, the OR for ACPA-positive RA was 0.6 (95% CI 0.3-0.9), while there was no association between BMI and ACPA-positive RA among women (OR 1.0, 95% CI 0.8 -1.2). Conclusion. Our findings show that obesity is associated with developing ACPA-negative RA in women, and indicate an inverse association between BMI and ACPA-positive RA in men.

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Section: Discussionmentioning

confidence: 95%

Association between body mass index and anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis: Results from a population‐based case–control study

Wesley¹,

Bengtsson²,

Elkan³

et al. 2012

Arthritis Care & Research

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“…A possible explanation for the stronger associations observed in men than in women pertains to the potential confounding effect of hormonally mediated menopausal weight gain. 41,42 In fact, the effect of each dietary score became nonsignificant after adjustment for menopausal status. In terms of obesity risk, the smaller number of cases among women than men might have prevented observing significant associations due to insufficient statistical power.…”

Section: Discussionmentioning

confidence: 96%

Association between dietary scores and 13-year weight change and obesity risk in a French prospective cohort

et al. 2012

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BACKGROUND/OBJECTIVES:The relationship between diet quality and development of obesity is complex and unresolved. The aim of this study was to assess and compare the predictive value of six different dietary scores on both relative weight change and the risk of obesity after 13 years of follow-up in adults aged 45 years and older. SUBJECTS/METHODS: Six scores reflecting adherence to different nutritional recommendations (the French Programme National Nutrition Santé-Guideline Score (PNNS-GS), the Dietary Guidelines for Americans Index (DGAI), the Diet Quality IndexInternational (DQI-I), the Mediterranean Diet Scale (MDS), the relative Mediterranean Diet Score (rMED) and the Mediterranean Style Dietary Pattern Score (MSDPS)) were estimated in 3151 participants in the French SU.VI.MAX (SUpplé mentation en VItamines et Miné raux AntioXydants) study. Associations of dietary scores with 13-year weight change were assessed through multivariate linear regression models, and obesity risk was analyzed with logistic regression, providing odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Except for the MSDPS, higher scores, that is, better adherence to nutritional guidelines or to a Mediterranean diet, were associated with lower weight gain in men (all P-value for trend o0.05). In addition, among men, ORs for becoming obese after 13 years associated with a 1 s.d. increase in dietary scores ranged from 0.63, 95% CI: 0.51, 0.78 for DGAI to 0.72, 95% CI: 0.59, 0.88 for MDS. These associations were weaker or not statistically significant in women. CONCLUSION: Overall, the six dietary scores predicted obesity risk equally well. Among French adults, strong adherence to dietary guidelines appears to be protective with regard to weight gain and obesity, especially in men.

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“…We defined a weight gain of more than 8 kg over 10 years, as an obvious cutoff for weight gain. Because gender differences are regularly seen in matters of weight and weight regulation (Bradshaw et al 2013;Heidema et al 2010;Stevens et al 2010), we decided to study men and women separately. Indeed we found sex-specific genetic associations.…”

Section: Discussionmentioning

confidence: 99%

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

et al. 2014

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Weight gain, when it leads to overweight or obesity, is nowadays one of the major health problems. ACE, FTO, AKR1C2, TIMP4 and MMP2 genes have been implicated in previous studies on weight regulation. This study investigated the contribution of polymorphisms in these five candidate genes to the risk of weight gain over a 10-year time period. Two groups were selected from participants of the Doetinchem cohort study who were followed over a 10-year period: A stable weight group (±2 kg/10 year; n = 259) and a weight gainers group who increased their body weight by roughly 10 % ([8 kg/ 10 year; n = 237). Starting BMI was between 20 and 35 kg/m 2 and baseline age between 20 and 45 years. Selected SNPs and insert/deletion in candidate genes were measured in each group. In men, the allelic distribution of FTO rs9939609 (v 2 p = 0.005), ACE rs4340 (v 2 p = 0.006) and AKR1C2 rs12249281 (v 2 p = 0.019) differed between the weight stable and weight gainers group. Interaction between FTO rs9939609 and ACE rs4340 was observed. In women, the allelic distribution of MMP2 rs1132896 differed between the weight stable and weight gainers group (v 2 p = 0.00001). The A-allele of FTO was associated with a 1.999 higher risk of gaining weight in men (OR 1.99, p = 0.020), while in women, the C-allele of MMP2 was associated with a 2.509 higher risk of weight gain (OR 2.50, p = 0.001) over the 10-year period. We found that FTO in men and MMP2 in women are associated with weight gain over a 10-year follow-up period.

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Associations between gender, age and waist circumference

Cited by 30 publications

References 0 publications

Association between body mass index and anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis: Results from a population‐based case–control study

Association between body mass index and anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis: Results from a population‐based case–control study

Association between dietary scores and 13-year weight change and obesity risk in a French prospective cohort

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

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