Associations between follicular fluid high density lipoprotein particle components and embryo quality among in vitro fertilization patients

Kim, Keewan; Bloom, Michael S.; Browne, Richard W.; Bell, Erin M.; Yucel, Recai; Fujimoto, Victor Y.

doi:10.1007/s10815-016-0826-x

Cited by 21 publications

(17 citation statements)

References 71 publications

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“…In humans, smaller HDL particles exhibit higher antioxidant potential than larger HDL particles (Nobecourt et al, ). Additionally, an association between the presence of larger and medium HDL particles in FF with decreased embryo quality was observed (Kim et al, ). The source of HDL‐P used in this study was human plasma, which would indicate that average particle size may be larger than HDL observed in FF, as only smaller HDL particles (HDL 3 ) are present in FF due to the follicular membrane permeability (Shalgi et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…The source of HDL‐P used in this study was human plasma, which would indicate that average particle size may be larger than HDL observed in FF, as only smaller HDL particles (HDL 3 ) are present in FF due to the follicular membrane permeability (Shalgi et al, ). Furthermore, Kim et al () found 15 different compounds linked to the HDL particle and 26 different HDL particle sizes, demonstrating the complexity of the HDL particle, which reflects on its complex functionality.…”

Section: Discussionmentioning

confidence: 99%

“…The transfer of ApoAI and PON1 from blood to the FF occurs in parallel with HDL, since these components are positively correlated in both compartments, in humans (Browne et al, 2008) and cattle (Schneider, Absalon-Medina, Esposito, Correa, & Butler, 2013). Although the follicular membrane is semipermeable, suggesting that only small HDL particles (HDL 3 ) are presented in FF (Shalgi, Kraicer, Rimon, Pinto, & Soferman, 1973), some studies detected 26 different sizes of HDL particle in human FF (Kim et al, 2017).…”

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confidence: 99%

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Effect of high‐density lipoprotein on oocyte maturation and bovine embryo development in vitro

Rincón

Pradieé

Remião

et al. 2018

Reprod Domestic Animals

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High‐density lipoprotein (HDL) is the main lipoprotein in the follicular fluid, and it has anti‐inflammatory, antioxidant and cryoprotectant properties. The anti‐inflammatory potential and antioxidant potential are derived from its lipid composition, especially the apolipoprotein AI (ApoAI) and paraoxonase 1 (PON1). The aim of this study was to evaluate the effect of HDL during in vitro maturation (IVM) on oocyte maturation and early bovine embryo development. For this, cumulus–oocyte complexes (COCs) were obtained from bovine ovaries collected at a local slaughterhouse. COCs (n = 2,250) were allocated into three groups (n = 50 COCs/group) according to the addition of HDL protein (HDL‐P) during IVM for 22 hr: 0 (control), 50 and 150 mg/dl. After IVM, COCs were inseminated (in vitro fertilization) and cultivated for 7 days. Total cholesterol concentration, total protein, triglycerides and ApoAI concentrations on IVM medium increased proportionally to HDL‐P addition. However, PON1 activity was not detected in any treatment. The addition of HDL‐P did not affect nuclear maturation rate, endogenous reactive oxygen species and glutathione levels in COCs (p > 0.05). The highest HDL‐P concentration (150 mg/dl) decreased cleavage and blastocyst rate (p < 0.05). Moreover, the HDL‐P 150 mg/dl group had lower cellular count/blastocyst than the 50 mg/dl group (p < 0.05). However, the addition of HDL‐P did not affect relative gene expression of evaluated genes. In conclusion, the complex HDL/ApoAI obtained from human plasma, in the absence of PON1 activity during in vitro oocyte maturation, decreased initial embryo development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Effect of high‐density lipoprotein on oocyte maturation and bovine embryo development in vitro

Rincón

Pradieé

Remião

et al. 2018

Reprod Domestic Animals

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“…Human mechanistic studies relating individual circulating lipoproteins and fertility are scarce . There is extensive information characterising concentrations of lipoproteins in the oocyte, however, revealing that HDL‐C is the most abundant lipoprotein in follicular fluid, and appears to have a most influential role, implicated in embryo development and quality . Triglycerides are found in lower quantities in follicular fluid and LDL‐C is negligible .…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and time to pregnancy: a retrospective study of nulliparous women

Grieger

Grzeskowiak

Smithers

et al. 2019

BJOG

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Objective To determine: (1) the association between metabolic syndrome (MetS), time to pregnancy (TTP), and infertility; (2) associations between individual and an increasing number of MetS components, TTP, and infertility; and (3) whether these relationships differ by body mass index (BMI < 30 kg/m2 versus BMI ≥ 30 kg/m2). Design Retrospective cohort study. Setting Multiple centres (in Australia, Ireland, New Zealand, and the UK). Population Five thousand five hundred and nineteen low‐risk nulliparous pregnant women. Methods Data on retrospectively reported TTP (number of months to conceive) and a blood sample to assess metabolic health were collected between 14 and 16 weeks of gestation. MetS was defined according to the International Diabetes Federation criteria. Accelerated failure time models with log‐normal distribution were conducted to estimate time ratios (TRs) and 95% CIs. Differences in MetS on infertility (TTP > 12 months) were compared using a generalised linear model (Poisson distribution) with robust variance estimates (relative risks, RRs; 95% CIs). All analyses (entire cohort and split by BMI) were controlled for a range of maternal and paternal confounding factors. Main outcome measures Time to pregnancy and infertility. Results Of the 5519 women included, 12.4% (n = 684) had MetS. Compared with women without MetS, women with MetS had a longer TTP (adjusted TR 1.30; 95% CI 1.15–1.46), which was similar in women who were obese and in women who were not obese. Marginal estimates for median TTP in women with MetS versus without MetS was 3.1 months (3.0–3.3 months) versus 4.1 months (3.6–4.5 months), respectively. Women with MetS were at a 62% greater risk for infertility and were at a greater risk for infertility whether they were obese (adjusted RR 1.62; 95% CI 1.15–2.29) or not (adjusted RR 1.73; 95% CI 1.33–2.23). Reduced high‐density lipoprotein cholesterol (HDL‐C) and raised triglycerides (TGs) were the main individual components associated with risk for infertility. Conclusion Metabolic syndrome is associated with longer TTP and infertility, independent of obesity. Additional studies, before pregnancy, are required to support our findings and to determine the applicability of which combinations of metabolic abnormalities pose the greatest risk to delayed fertility, or whether individual components are amenable to modification. Tweetable abstract Metabolic syndrome is associated with longer time to pregnancy and infertility, independent of obesity.

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“…Cholesterol is known to be essential for the process of steroidogenesis, and serum free cholesterol concentrations have been associated with fecundity in both sexes [11, 15]. HDL cholesterol is, along with Apolipoprotein b (Apo b) [17, 18], the predominant lipoprotein in ovarian follicles, and is associated with embryo quality and fertility treatment outcomes [16, 19]. Human studies have reported appreciably higher clinical pregnancy rate and number of top-quality embryos in high Apo b patients undergoing fertility treatment, compared with low Apo b patients, even after exclusion of ovarian-related disorders [17].…”

Section: Introductionmentioning

confidence: 99%

Lipid levels after childbirth and association with number of children: A population-based cohort study

et al. 2019

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ObjectiveLow parity women are at increased risk of cardiovascular mortality. Unfavourable lipid profiles have been found in one-child mothers years before they conceive. However, it remains unclear whether unfavourable lipid profiles are evident in these women also after their first birth. The aim was to estimate post-pregnancy lipid levels in one-child mothers compared to mothers with two or more children and to assess these lipid’s associations with number of children.MethodsWe used data on 32 618 parous women (4 490 one-child mothers and 28 128 women with ≥2 children) examined after first childbirth as part of Cohort of Norway (1994–2003) with linked data on reproduction and number of children from the Medical Birth Registry of Norway (1967–2008). Odds ratios (ORs) with 95% confidence intervals (CIs) for one lifetime pregnancy (vs. ≥2 pregnancies) by lipid quintiles were obtained by logistic regression and adjusted for age at examination, year of first birth, body mass index, oral contraceptive use, smoking and educational level.ResultsCompared to women with the lowest quintiles, ORs for one lifetime pregnancy for the highest quintiles of LDL and total cholesterol were 1.30 (95%CI: 1.14–1.45) and 1.43 (95%CI: 1.27–1.61), respectively. Sensitivity analysis (women <40 years) showed no appreciable change in our results. In stratified analyses, estimates were slightly stronger in overweight/obese, physically inactive and women with self-perceived bad health.ConclusionsMean lipid levels measured after childbirth in women with one child were significantly higher compared to mothers with two or more children and were associated with higher probability of having only one child. These findings corroborate an association between serum lipid levels and one lifetime pregnancy (as a feature of subfecundity), emphasizing that these particular women may be a specific predetermined risk group for cardiovascular related disease and death.

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Associations between follicular fluid high density lipoprotein particle components and embryo quality among in vitro fertilization patients

Cited by 21 publications

References 71 publications

Effect of high‐density lipoprotein on oocyte maturation and bovine embryo development in vitro

Effect of high‐density lipoprotein on oocyte maturation and bovine embryo development in vitro

Metabolic syndrome and time to pregnancy: a retrospective study of nulliparous women

Lipid levels after childbirth and association with number of children: A population-based cohort study

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