Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease

Domingo, Peré; Muñiz‐Díaz, Eduardo; Baraldès, Maria A.; Arilla, Marina; Barquet, Nicolau; Pericàs, Juan M.; Júarez, Cándido; Madoz, P; Vázquez, Guillermo

doi:10.1016/s0002-9343(01)01047-6

Cited by 76 publications

(38 citation statements)

References 30 publications

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“…Consistent with our findings, previous studies have shown an increased susceptibility to bacterial infections by encapsulated bacteria in patients with the R/R genotype of FcgRIIA 18,35 and it has been reported that the frequency of both heterozygous FcgRIIA H/R and homozygous R/R was higher in patients with recurrent bacterial respiratory tract infections than in controls. 18 However, the lack of difference in the frequency of FcgRIIA genotypes in CF patients and control subjects observed in this study and the lack of association between these genotypes and other parameters of disease severity, as well as the contribution of other variables to the increased risk of acquiring P. aeruginosa infection, support the concept that the severity of pulmonary involvement in CF is controlled by multifactorial genetic mechanisms and suggest that other genetic factors may influence susceptibilities and outcomes in which Fcg receptors play a role.…”

Section: Discussionsupporting

confidence: 93%

Fcγ receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis

et al. 2004

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It has been suggested that genes other than CFTR could modulate the severity of lung disease in cystic fibrosis (CF). Neutrophil Fcc receptor II (FccRII) is involved in host defense against microorganisms and in inflammatory response. We evaluated the association between genetic variability of this gene and both airway infection with Pseudomonas aeruginosa and severity of lung disease in patients with CF. We studied 167 Italian unrelated patients with CF and 50 control subjects. The distribution of FccRIIA genotypes in CF patients was compared with that in control subjects and the different genotypes were related with the presence or absence of P. aeruginosa infection and markers of disease severity in CF patients. The distribution of FccRIIA genotypes was not significantly different between CF patients and controls. We observed that in CF patients with the same CFTR genotype (DF508/DF508), those carrying the R allele of FccRIIA had an increased risk of acquiring chronic P. aeruginosa infection (P ¼ 0.042, R.R.: 4.38; 95% CI: 1.17C22.4). Moreover, the frequency of R/R genotype in patients with chronic P. aeruginosa infection seems to be higher than that of control subjects and patients without chronic infection. The observation that CF patients carrying the R allele of FccRIIA are at higher risk of acquiring chronic P. aeruginosa infection suggests that the FccRII loci genetic variation is contributing to this infection susceptibility.

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Section: Discussionsupporting

confidence: 93%

Fcγ receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis

et al. 2004

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“…Several studies have found associations of FCGR2A polymorphisms with susceptibility to meningococcal disease, 23 periodontal disease 24 recurrent bacterial respiratory tract infection in children with low IgG2 anticarbohydrate antibodies 25 bacteremic pneumococcal pneumonia, 26 and invasive pneumococcal infections in patients with SLE. 27 The FCGR2A 131 H/R SNP strongly influences the ability of the receptor to bind human IgG 2 , the isotype often made in response to encapsulated bacteria.…”

Section: Discussionmentioning

confidence: 99%

Genetic risk factors for infection in patients with early rheumatoid arthritis

et al. 2004

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We analyzed clinical and genetic factors contributing to infections in 457 subjects with early rheumatoid arthritis (RA) enrolled in a prospective, 1-year clinical trial of methotrexate and the TNF inhibitor etanercept. Subjects were genotyped for the following single nucleotide polymorphisms (SNPs): (TNF À308, À238, and þ 488); lymphotoxin-a (LTA) (LTA þ 249, þ 365, and þ 720); and Fc gamma receptors FCGR2A 131 H/R; FCGR3A 176 F/V; and FCGR3B NA 1/2 and genotypes were correlated with infections. At least one URI was noted in 52% of subjects (99/191) with the NA2/NA2 genotype of the neutrophil-specific FCGR3B gene, compared to 42% (77/181) of those with the NA1/NA2 genotype and 39% (23/59) of those with the NA1/NA1 genotype (P ¼ 0.038). Urinary tract infection (UTI) was associated with the TNF À238 A (odds ratio(OR) 2.56, 95% confidence interval (CI) 1.05-6.25) and LTA þ 365 C (OR 1.73, 95% CI 1.07-2.79) alleles, and marginally with the FCGR3A F allele (OR 1.72, 95% CI 0.99-3.00). There was a striking linear correlation between UTI and the number of risk alleles defined by these three SNPs (Po0.001), suggesting an additive effect on susceptibility. These findings have important implications for the role of genetics in susceptibility to bacterial and viral infections.

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“…However, FcγR-mediated phagocytosis can be demonstrated in vitro (232,233). Furthermore, some studies, but not all, have found associations between FcγRIIa genotypes and susceptibility to or severity of meningococcal infection (233,234,235,236,237,238). Finally, γδT cells capable of phagocytosing antibody-opsonized E. coli via FcγRIIIa have been described (239).…”

Section: Phagocytosismentioning

confidence: 99%

Functions of Antibodies

Forthal

2014

Microbiol Spectr

169

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Antibodies can impact pathogens in the presence or in the absence of effector cells or effector molecules such as complement, and experiments can often sort out with precision the mechanisms by which an antibody inhibits a pathogen in vitro. In addition, in vivo models, particularly those engineered to knock in or knock out effector cells or effector molecules, are excellent tools for understanding antibody functions. However, it is highly likely that multiple antibody functions occur simultaneously or sequentially in the presence of an infecting organism in vivo. The most critical incentive for measuring antibody functions is to provide a basis for vaccine development and for the development of therapeutic antibodies. In this respect, some functions, such as virus neutralization, serve to inhibit the acquisition of a pathogen or limit its pathogenesis. However, antibodies can also enhance replication or contribute to pathogenesis. This review emphasizes those antibody functions that are potentially beneficial to the host. In addition, this review will focus on the effects of antibodies on organisms themselves, rather than on the toxins the organisms may produce.

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Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease

Cited by 76 publications

References 30 publications

Fcγ receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis

Fcγ receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis

Genetic risk factors for infection in patients with early rheumatoid arthritis

Functions of Antibodies

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