Associations between diurnal cortisol patterns and lifestyle factors, psychotic symptoms, and neurological deficits: A longitudinal study on patients with chronic schizophrenia

Ho, Rainbow T. H.; Fong, Ted C. T.; Wan, Adrian H. Y.; Au-Yeung, Friendly S.W.; Chen, Eric; Spiegel, David

doi:10.1016/j.jpsychires.2016.06.014

Cited by 17 publications

(11 citation statements)

References 41 publications

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“…Interestingly, hyper-reactivity of the HPA axis is observed in both individuals with SZ and individuals at high genetic risk for SZ, which may support the model of stress vulnerability in SZ 158 . Furthermore, altered regulation of the HPA axis in SZ is predictive of more severe psychotic and motor symptoms 159,160 . Fortunately SZ-associated HPA axis hyperactivity is responsive to treatment; 4 weeks of treatment with olanzapine produces cortisol concentrations that are comparable to healthy controls 161 .…”

Section: Circadian Rhythm Disruption and Schizophreniamentioning

confidence: 99%

Circadian rhythm disruption and mental health

et al. 2020

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Circadian rhythms are internal manifestations of the solar day that permit adaptations to predictable environmental temporal changes. These~24-h rhythms are controlled by molecular clockworks within the brain that are reset daily to precisely 24 h by exposure to the light-dark cycle. Information from the master clock in the mammalian hypothalamus conveys temporal information to the entire body via humoral and neural communication. A bidirectional relationship exists between mood disorders and circadian rhythms. Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion, whereas disruption of circadian rhythms via jet lag, night-shift work, or exposure to artificial light at night, can precipitate or exacerbate affective symptoms in susceptible individuals. Evidence suggests strong associations between circadian rhythms and mental health, but only recently have studies begun to discover the direct interactions between the circadian system and mood regulation. This review provides an overview of disrupted circadian rhythms and the relationship to behavioral health and psychiatry. The focus of this review is delineating the role of disruption of circadian rhythms on mood disorders using human night shift studies, as well as jet lag studies to identify links. We also review animal models of disrupted circadian rhythms on affective responses. Lastly, we propose low-cost behavioral and lifestyle changes to improve circadian rhythms and presumably behavioral health.

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Section: Circadian Rhythm Disruption and Schizophreniamentioning

confidence: 99%

Circadian rhythm disruption and mental health

et al. 2020

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“…Although there are few studies on cortisol stress response in patients with schizophrenia, there are some studies on other cortisol indicators, and the results are inconsistent. Most of them found no signi cant correlation between cortisol and symptoms [34][35][36] , with similar ndings for CHR patients [17,20] . However, a study of treatment-resistant patients with schizophrenia found that patients' serum cortisol levels were signi cantly reduced in the morning after treatment, and, although the correlation was weak, it was related to improvement in PANSS negative symptoms [37] .…”

Section: Clinical Symptoms and Other Indicatorsmentioning

confidence: 74%

Cortisol Response to Psychological Stress in Patients with Schizophrenia in The Chinese Population

Zhu

Huang

et al. 2021

Preprint

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Background: Accumulating evidence suggests that hypothalamic-pituitary-adrenal (HPA) axis dysfunction might play an important role in the pathophysiology of schizophrenia. Cortisol secretion levels can reflect the function of the HPA axis.This study aimed to explore the cortisol response to psychological stress in patients with schizophrenia. Methods: In this cross-sectional study study, patients with schizophrenia (n = 104) and healthy volunteers (n = 59) were asked to complete psychological stress challenge tasks, which included the Paced Auditory Serial Addition Task and Mirror-Tracing Persistence Task, and then, saliva was collected to measure cortisol levels. Emotions and psychopathology were assessed by the Positive and Negative Affect Schedule (PANAS) and Positive and Negative Syndrome Scale (PANSS). Results: (1) that the cortisol stress response and negative emotions in patients with schizophrenia differed significantly from those in healthy controls; (2) there were significant interactions between sampling time and diagnosis for saliva cortisol levels; (3) there were significant interactions between scoring time and diagnosis for the negative affect score of the PANAS; and (4) the changes in salivary cortisol levels and negative affect scores before and after the psychological stress challenge tasks were not correlated with clinical symptoms in patients with schizophrenia. Conclusions: These findings indicated that an abnormal cortisol stress response might be a stable biological characteristic of schizophrenia.

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“…Preclinical studies have previously documented positive effects of environmental enrichment on HPA-axis structures, including the adrenal glands, which are involved in the regulation of glucocorticoids 36 . Studies in older adults and other clinical populations, including schizophrenia, have additionally reported a negative effect of unhealthy lifestyle behaviours, such as physical inactivity and social isolation on cortisol regulation 27,37 . It was therefore hypothesised that lifestyle factors, particularly physical activity, cognitive reserve and social network size would be negatively associated with cortisol levels such that greater physical activity, cognitive reserve and social network size would be associated with lower cortisol levels.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep quality was measured using the Pittsburgh Sleep Quality Index. These measures were purposefully selected as they have been shown to be associated with measures of disease progression in HD 24,25 as well as cortisol regulation in the elderly and other clinical populations 26,27 .…”

Section: Cortisol Measures Hair Cortisolmentioning

confidence: 99%

Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease

Cruickshank

Porter

Laws

et al. 2021

Sci Rep

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Salivary cortisol dysrhythmias have been reported in some, but not all studies assessing hypothalamic–pituitary–adrenal (HPA) axis function in Huntington’s disease (HD). These differences are presumed to be due to environmental influences on temporal salivary cortisol measurement. Further exploration of HPA-axis function using a more stable and longer-term measure, such as hair cortisol, is needed to confirm earlier findings. This study aimed to evaluate hair and salivary cortisol concentrations and their associations with clinical and lifestyle outcomes in individuals with premanifest HD (n = 26) compared to healthy controls (n = 14). Participants provided saliva and hair samples and data were collected on clinical disease outcomes, mood, cognition, physical activity, cognitive reserve, sleep quality and social network size to investigate relationships between clinical and lifestyle outcomes and cortisol concentrations. Hair and salivary cortisol concentrations did not significantly differ between the premanifest HD and control groups. No significant associations were observed between hair or salivary cortisol concentrations and cognitive, mood or lifestyle outcomes. However, hair cortisol concentrations were significantly associated with disease outcomes in individuals with premanifest HD. Significant associations between hair cortisol concentrations and measures of disease burden and onset may suggest a potential disease marker and should be explored longitudinally in a larger sample of individuals with HD.

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Associations between diurnal cortisol patterns and lifestyle factors, psychotic symptoms, and neurological deficits: A longitudinal study on patients with chronic schizophrenia

Cited by 17 publications

References 41 publications

Circadian rhythm disruption and mental health

Circadian rhythm disruption and mental health

Cortisol Response to Psychological Stress in Patients with Schizophrenia in The Chinese Population

Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease

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