Associations between dietary flavonoid intake with hepatic steatosis and fibrosis quantified by VCTE: Evidence from NHANES and FNDDS

Xie, Ruijie; Zhang, Ya

doi:10.1016/j.numecd.2023.03.005

Cited by 35 publications

(22 citation statements)

References 51 publications

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“…Studies have found that the incidence of NAFLD in males and postmenopausal females is higher than that in premenopausal females, indicating that oestradiol has a protective effect on liver disease and is related to the progression of NAFLD [41]. Flavonoid is a major class of phytoestrogens with oestrogenic and antiestrogenic activities [42]. Possible explanations for the sex differences are, therefore, due to differences in hormones between the sexes and the complex effects of different flavonoids in different individuals [43].…”

Section: Discussionmentioning

confidence: 99%

Interaction between dietary flavonoid intake and trouble sleeping on non-alcoholic fatty liver disease risk: a cross-sectional study

Yang,

Zhuo,

Fang

2023

European Journal of Gastroenterology &Amp; Hepatology

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Objective The possible interaction of dietary flavonoid intake and sleep on non-alcoholic fatty liver disease (NAFLD) has not been well studied. This study investigated the interaction between dietary flavonoid intake and trouble sleeping on the risk of NAFLD. Methods Three discrete National Health and Nutrition Examination Survey data cycles from 2007 to 2010 and 2017 to 2018 were used. NAFLD was diagnosed by a US Fatty Liver Index ≥30. A sleep questionnaire diagnosed trouble sleeping. Univariate and multivariate logistic regression, restricted cubic spline (RCS) and subgroup analyses were used to evaluate the association between dietary flavonoids, trouble sleeping and NAFLD. We employed the relative excess risk due to interaction, attributable proportion of interaction and synergy index to evaluate additive interactions. Results Ultimately, 5056 participants were enrolled, and higher anthocyanidins and flavanones intake was negatively correlated with NAFLD. Conversely, trouble sleeping was positively associated with NAFLD. These correlations remained stable after adjusting for confounders, and there was a sex difference in this relationship. In the RCS model, anthocyanins were negatively non-linearly related to NAFLD, while flavanones showed a negative linear relationship. Moreover, there was a synergistic interplay between low dietary anthocyanin intake and trouble sleeping on the risk of NAFLD. A similar relationship existed for flavanone intake. Conclusion Anthocyanin and flavanone intake were negatively associated, whereas trouble sleeping was positively associated with NAFLD risk. There was a synergistic effect of low anthocyanin intake and trouble sleeping. The same relationship existed for low flavanone intake.

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Section: Discussionmentioning

confidence: 99%

Interaction between dietary flavonoid intake and trouble sleeping on non-alcoholic fatty liver disease risk: a cross-sectional study

Yang,

Zhuo,

Fang

2023

European Journal of Gastroenterology &Amp; Hepatology

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“…Nonlinear relationships were evaluated using smoothed curve fits and generalized additive models. [20][21][22] Statistical significance was determined using a 2-tailed P value < .05. In the subgroup analysis stratified by gender or race, the model is not adjusted for the stratification variable itself.…”

Section: Discussionmentioning

confidence: 99%

Association between urine caffeine metabolites and bone mineral density: A population-based study

Tan,

Shen,

Tang

et al. 2023

Medicine

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The association between coffee intake and bone mineral density (BMD) remains a subject of debate in epidemiological research. Furthermore, the potential relationship between BMD and urine caffeine or caffeine metabolites has not yet been explored. Therefore, the present study aimed to investigate the possible association between BMD and urine caffeine and its metabolites in U.S. adults. We employed multivariate linear and logistic regression models to analyze the relationship between urine caffeine and caffeine metabolites and lumbar BMD using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014. Additionally, fitted smoothing curves and generalized additive models were used. After adjusting for several factors, we found no significant association between urine caffeine and its metabolites and BMD. However, subgroup analyses stratified by gender and ethnicity showed that the relationship between urine caffeine and its metabolites and lumbar BMD remained consistent. Our investigation revealed that the inflection points for the U-shaped relationship between urinary theophylline and paraxanthine and BMD were observed at levels of 0.006 mmol/L for theophylline and 0.052 mmol/L for paraxanthine. In this cross-sectional study, we found no significant correlation between urine caffeine and its metabolites and BMD. However, more research is required to confirm our findings, as well as to investigate the underlying mechanisms.

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“…Sample weights were incorporated to ensure the outcomes reflected a statistically representative snapshot of the American non-hospitalization population. [25] The NHANES website offered recommendations using suitable sampling weights for statistical analyses. NHANES 1999 to 2000 overview mentioned most data analyses required either the interviewed sample weight (variable name: WTINT2YR) or examined sample weight (variable name: WTMEC2YR).…”

Section: Methodsmentioning

confidence: 99%

Associations between weight-adjusted-waist index and telomere length: Results from NHANES: An observational study

Xia,

Xu,

et al. 2024

Medicine

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Previous studies have demonstrated the connection between obesity and telomere length. A recently devised metric for determining obesity, the weight-adjusted-waist index (WWI), offers a distinct advantage in predicting fat and lean mass by depicting weight-independent abdominal adiposity. This article presents the results of the inaugural study on the relationship between WWI and telomere length in adult populations. The cross-sectional investigation analyzed data from 3479 participants from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2000. To inspect linear and nonlinear correlations, we adopted weighted multiple logistic regression analysis and smooth curve fit, respectively. In addition, threshold effects and subgroup analyses were accomplished. In the fully adapted model, a significant adverse association of WWI with telomere length was detected [β = −0.02, 95% CI: (−0.03, −0.00), P value = 0.01]. The adverse correlation remained consistent across all subcategories. We also discovered an inverted U-shaped curve linking WWI and telomere length, with a conspicuous inflection point of 10.07 cm/√kg. For the first time, our research demonstrated strong links between WWI and telomere length. The inflection point suggests that controlling WWI within an optimum range might be essential for aging and health.

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Associations between dietary flavonoid intake with hepatic steatosis and fibrosis quantified by VCTE: Evidence from NHANES and FNDDS

Cited by 35 publications

References 51 publications

Interaction between dietary flavonoid intake and trouble sleeping on non-alcoholic fatty liver disease risk: a cross-sectional study

Interaction between dietary flavonoid intake and trouble sleeping on non-alcoholic fatty liver disease risk: a cross-sectional study

Association between urine caffeine metabolites and bone mineral density: A population-based study

Associations between weight-adjusted-waist index and telomere length: Results from NHANES: An observational study

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