Associations between dietary factors and urinary concentrations of organophosphate and pyrethroid metabolites in a Canadian general population

Ye, Ming; Beach, Jeremy; Martin, Jonathan W.; Senthilselvan, Ambikaipakan

doi:10.1016/j.ijheh.2015.06.006

Cited by 60 publications

(30 citation statements)

References 49 publications

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“…Creatinine is often used as an indicator of dilution in urinary biomarker analyses, including analyses of CHMS biomonitoring data [31,83,84]. The traditional and commonly used approach simply divides the concentration of the analyte by the urinary concentration of creatinine, thereby providing concentration values expressed by unit creatinine.…”

Section: Limitationsmentioning

confidence: 99%

The influence of demographic and lifestyle factors on urinary levels of PAH metabolites—empirical analyses of Cycle 2 (2009–2011) CHMS data

Keir

Cakmak

Blais

et al. 2020

J Expo Sci Environ Epidemiol

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Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds formed during the incomplete combustion of organic matter. Several are mutagenic carcinogens; the magnitude of exposure can be assessed by examining urinary levels of PAH metabolites. Data from biomonitoring studies that record urinary PAH metabolite levels, as well as demographic and lifestyle information, can be used to investigate relationships between PAH exposure and variables, such as smoking status, workplace smoking restrictions, age, sex, household income, home age, and occupation. This study analysed creatinineadjusted urinary PAH metabolite concentrations and questionnaire data from~1200 individuals aged 16 years and older surveyed in Cycle 2 of the Canadian Health Measures Survey (CHMS). Statistical analyses revealed that smoking status, age, and sex are associated with urinary concentrations of a pyrene metabolite (1-OHP), phenanthrene metabolites (ΣOH-Phen), fluorene metabolites (ΣOH-Flu) and naphthalene metabolites (ΣOH-Nap). More specifically, smoking status, age and sex can collectively account for 30, 24, 52, and 34% of the observed variations in 1-OHP, ΣOH-Phen, ΣOH-Flu and ΣOH-Nap metabolites, respectively (p < 0.001). Analyses of non-smokers revealed weak but significant effects of age, sex, home age, and occupation on urinary levels of selected PAH metabolites (i.e., <7% of observed variation, p < 0.05). The unexplained variation in PAH metabolite levels is most likely related to diet, which was not examined. Although the results revealed significant relationships between urinary PAH metabolite levels and several lifestyle and/or demographic variables, robust examinations of selected effects (e.g., sex, home age, occupation) will require datasets that are balanced with respect to the other highlighted variables. The results can be used to identify remedial measures to reduce exposure and concomitant risk, and/or design follow-up studies to test hypotheses regarding the causes of exposure differences empirically related to sex, age, home age, and occupation.

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Section: Limitationsmentioning

confidence: 99%

The influence of demographic and lifestyle factors on urinary levels of PAH metabolites—empirical analyses of Cycle 2 (2009–2011) CHMS data

Keir

Cakmak

Blais

et al. 2020

J Expo Sci Environ Epidemiol

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“…However, for the general populations, diet was potentially the major route of exposures to pyrethroids 6 51. Ye et al 51 have shown that for the CHMS participants eating vegetables in a high frequency, the urinary concentrations of pyrethroids were 1.42 times (95% CI 1.23 to 1.66) higher than those with a low frequency, and concentrations of pyrethroids were also positively associated with pulses/nuts consumption (p<0.01). Therefore, it is unlikely that the CHMS participants in this study, especially children and adolescents, were exposed via inhalation, unless they lived in or next to a farm or had been gardening on a regular basis.…”

Section: Discussionmentioning

confidence: 99%

Urinary concentrations of pyrethroid metabolites and its association with lung function in a Canadian general population

Beach

Martin

et al. 2016

Occup Environ Med

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“…OP residues have been detected in a variety of fruits and vegetables, in milk, soil, drinking water, fish, and stored grains. Moreover, in several studies from Turkey and from other countries a significant proportion of the samples was determined to contain OPs above the tolerance limit [11,37].…”

Section: Discussionmentioning

confidence: 99%

“…Toxic effects of low-dose, long-term environmental exposure to OPs without acute poisoning are matters for researches recently. The consumption of foods contaminated with OPs residues is the most frequent reason for exposure [11]. Two of the other causes of low doselong term exposure to pesticides are related to the consumption of contaminated water and the inhalation of contaminated air by residues [12].…”

Section: Introductionmentioning

confidence: 99%

The Red Blood Cell Acetylcholinesterase Levels of Depressive Patients with Suicidal Behavior in an Agricultural Area

et al. 2016

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Long-term exposure to organophosphate pesticides (OPs) without acute poisoning can lead to various OPs. Environmental exposure to organophosphate pesticides may be associated with depression and suicide attempts in a population living in a rural agricultural area. Patients (n = 149) suffering from major depressive disorder (with and without attempted suicide) and a control group of healthy individuals (n = 64) who had been living in the same rural district for at least 1 year were selected. Red blood cell acetylcholine esterase (RBC-AChE) activity was examined as the basis of evaluating the degree of chronic environmental exposure to OPs residues. There were negative association between RBC-AChE activity levels and suicide attempts, the number of past suicide attempts and hopelessness levels in the depressive patients.The results of the study may support the idea that environmental exposure to OPs may be associated with mental health in individuals living in agricultural districts who are not farmers or working in occupations with access to OPs.

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Associations between dietary factors and urinary concentrations of organophosphate and pyrethroid metabolites in a Canadian general population

Cited by 60 publications

References 49 publications

The influence of demographic and lifestyle factors on urinary levels of PAH metabolites—empirical analyses of Cycle 2 (2009–2011) CHMS data

The influence of demographic and lifestyle factors on urinary levels of PAH metabolites—empirical analyses of Cycle 2 (2009–2011) CHMS data

Urinary concentrations of pyrethroid metabolites and its association with lung function in a Canadian general population

The Red Blood Cell Acetylcholinesterase Levels of Depressive Patients with Suicidal Behavior in an Agricultural Area

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