Associations between dietary copper intake and hypertriglyceridemia among children and adolescents in the US

Shi, Yumeng; Hu, Huan; Wu, Zuxiang; Jiang, Wu; Chen, Zhiqiang; Cheng, Xiaoshu; Li, Ping

doi:10.1016/j.numecd.2023.01.020

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…However, our results are consistent with those reported in Chinese adult women where it was observed that the serum Cu level was positively associated with the serum triglyceride concentration [43]. Another study in children and adolescents from the U.S. reported that higher dietary Cu intake increases the risk of hypertriglyceridemia [44]. Until now, the biological mechanism to explain the relationship between serum Cu levels and hypertriglyceridemia is still unclear.…”

Section: Discussionsupporting

confidence: 92%

Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults

Ramírez-Cruz,

Rios-Lugo,

Soto-Sánchez

et al. 2024

Metabolites

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Recently, the role of trace elements in the pathophysiology of obesity, insulin resistance (IR), and metabolic diseases has been explored. In this cross-sectional study, we aimed to assess the association of overweight, obesity, and cardiometabolic traits with serum copper (Cu) levels in 346 Mexican adults. Serum Cu level was measured by inductively coupled plasma mass spectrometry (ICP-MS). Anthropometrical data were collected, and biochemical parameters were measured. The triglyceride-glucose (TyG) index was used as a surrogate marker to evaluate IR. Overweight and obesity status was positively associated with the serum Cu level (β = 19.434 ± 7.309, p = 0.008). Serum Cu level was observed to have a positive association with serum triglycerides level (β = 0.160 ± 0.045, p < 0.001) and TyG (β = 0.001 ± 0.001, p < 0.001). Additionally, high serum Cu level was positively associated with overweight and obesity status (odds ratio [OR] = 1.9, 95% confidence interval [95% CI] 1.1–3.4, p = 0.014), hypertriglyceridemia (OR = 3.0, 95% CI 1.7–5.3, p < 0.001), and IR (OR = 2.6, 95% CI 1.4–4.6, p = 0.001). In conclusion, our results suggest that overweight, obesity, hypertriglyceridemia, and IR are positively associated with serum Cu levels in Mexican adults.

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Section: Discussionsupporting

confidence: 92%

Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults

Ramírez-Cruz,

Rios-Lugo,

Soto-Sánchez

et al. 2024

Metabolites

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“…Compared with individuals with a low BMI, a strong correlation was observed between dietary Cu intake and increased hyperlipidemia. [ 35 ] Hence, a reduction in dietary Cu intake may be recommended for underweight participants to prevent GSD.…”

Section: Discussionmentioning

confidence: 99%

The association between intakes of dietary trace minerals and gallstone disease: A cross-sectional study from National Health and Nutrition Examination Survey 2017 to 2018

Yan,

Yu,

Fang

et al. 2024

Medicine

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The gallstone disease is becoming increasingly prevalent worldwide. Dietary trace minerals have been proven to be closely related to many metabolic diseases, and this study aims to explore the association between intakes of dietary trace minerals (copper, iron, selenium, and zinc) and gallstone disease (GSD). Using the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2018, intakes of dietary trace minerals and GSD data were obtained through a 24-hour recall and diagnostic questionnaire, respectively. Weighted logistic regression models were used to identify the association between intakes of dietary trace minerals and the prevalence of GSD, and the results were presented as odds ratios (OR) and 95% confidence intervals (95% CI). A total of 4077 participants were included in the final analysis, of which 456 participants had GSD and 3621 participants serving as the control group. No significant associations between GSD and intakes of dietary trace minerals (iron, selenium, and zinc) were found. However, after adjusting for all covariates, significant association was demonstrated between dietary copper (Cu) intake and GSD (OR = 0.66, 95% CI = 0.45–0.98). After conducting a weighted quantile logistic regression, a significant negative correlation was also found between dietary Cu intake and highest GSD quartile (Q4) (OR = 0.45, 95% CI = 0.26–0.80). Following the research outlined above, no association was found between intakes of dietary trace minerals (iron, selenium, and zinc) and GSD; however, a linear negative association was identified between dietary Cu intake and GSD.

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“…Based on prior research concerning factors correlated with HTG in the youthful demographic and cognizant of the pronounced disparities in individual ramifications from potential confounders [27][28][29][30], we incorporated the following variables for comprehensive adjustment: continuous variables: Albumin (g/dL), Alanine Aminotransferase (ALT, u/L), Aspartate Aminotransferase (AST, u/L), Alkaline phosphatase (ALP, U/L), Creatinine (umol/L), Gamma glutamyl transferase (GGT, U/L), Glucose (mmol/L), Lactate dehydrogenase (LDH, U/L), Total protein (g/dL), systolic blood pressure (SBP, mmHg), diastolic blood pressure (DBP mmHg), and dietary data [Total saturated fatty acids (g), Total monounsaturated fatty acids (g) and Total polyunsaturated fatty acids (g)] and categorical variables: sex (male, female) and race (non-Hispanic white, non-Hispanic Black, Mexican American and other).…”

Section: Other Covariatesmentioning

confidence: 99%

Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

Si,

Chen,

Zhang

2024

Lipids Health Dis

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Background Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. To fill the gaps in epidemiology,this study focused on analyzing the relationship between the levels of uric acid and HTG in a demographic sample comprising adolescents from the United States. Methods In this study, a total of 4,435 participants through the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The exposure variable was serum uric acid (SUA), the effect variable was HTG, and the covariates included demographic, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential nonlinear correlations. Results The study included 4,435 participants. Male adolescents exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA was positively correlated with HTG risk (OR = 1.006, 95% CI: 1.005–1.007). This relationship was consistent across the three tertiles group of SUA (T1: OR = 1.006 [95% CI: 1.005–1.007]; T2: OR = 1.006 [95% CI: 1.005–1.007]; T3: OR = 1.004 [95% CI: 1.003–1.006]; P for trend < 0.001). Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age or race. Conclusions In American children and adolescents aged 12 to 18 years, there was a pronounced association between SUA and HTG. SUA could serve as a risk indicator for HTG. It is recommended that children diagnosed with HTG should be regularly tested for SUA levels. In addition, it is recommended that SUA be included in the comprehensive care of children diagnosed with HTG.

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Associations between dietary copper intake and hypertriglyceridemia among children and adolescents in the US

Cited by 5 publications

References 35 publications

Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults

Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults

The association between intakes of dietary trace minerals and gallstone disease: A cross-sectional study from National Health and Nutrition Examination Survey 2017 to 2018

Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study

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