Associations between daily physical activity, handgrip strength, muscle mass, physical performance and quality of life in prefrail and frail community-dwelling older adults

Haider, Sandra; Luger, Eva; Kapan, Ali; Titze, Sylvia; Lackinger, Christian; Schindler, Karin; Dörner, Thomas

doi:10.1007/s11136-016-1349-8

Cited by 83 publications

(92 citation statements)

References 43 publications

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“…Literature suggests that excessively accumulating life stress, not only diminishes health, but simultaneously reduces physical activity uptake . Indeed, both a reduction in physical health and low levels of physical activity have been shown to be associated with lower grip strength . Importantly, cortisol may be independently associated with grip strength as it stimulates degradation and inhibits synthesis of muscle proteins, and thus is feasibly associated with grip strength.…”

Section: Introductionmentioning

confidence: 99%

“…20 Indeed, both a reduction in physical health and low levels of physical activity have been shown to be associated with lower grip strength. 7,21 Importantly, cortisol may be independently associated with grip strength as it stimulates degradation and inhibits synthesis of muscle proteins, 22 and thus is feasibly associated with grip strength. A relationship between grip strength and stress is likely bidirectional; that is, stress may lead to lower grip strength via the mechanisms explained above and low grip strength (an indicator of frailty) may lead to higher chronic stress via, for example, reduced quality of life or increasing difficulty in completing daily tasks.…”

Section: Introductionmentioning

confidence: 99%

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The association of grip strength with depressive symptoms and cortisol in hair: A cross‐sectional study of older adults

Smith

Firth

Grabovac

et al. 2019

Scandinavian Med Sci Sports

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Background Low handgrip strength has been shown to be associated with higher levels of depressive symptoms. One area of mental health that is understudied in relation to grip strength is chronic stress, which can exist independently to depression, or as a comorbidity or precursor to this condition. The present study examined cross‐sectional associations between grip strength, an established marker of physical function, and (a) depressive symptoms and (b) chronic stress utilizing hair cortisol concentrations, while accounting for multiple pertinent confounding variables. Method Data were used from wave 6 (2012/13) of the English Longitudinal Study of Aging, a panel study of older (≥50 years) community‐dwelling men and women. Grip strength was measured in kg using a hand‐held dynamometer. Depressive symptoms were assessed using the 8‐item Center for Epidemiologic Studies Depression scale. Hair cortisol concentrations (pg/mg) were determined from samples of scalp hair and log‐transformed for analysis to correct skewness. Associations of grip strength with depressive symptoms and hair cortisol concentration were tested using linear regression models adjusted for age, sex, ethnicity, wealth, smoking status, physical activity, body mass index, limiting long‐standing illness, arthritis, diabetes, and hair treatment. Results The sample comprised of 3741 participants (mean age 68.4 years, 66.4% female). After adjustment for age and sex, grip strength was significantly and negatively associated with both depressive symptoms (B = −0.038, SE = 0.004, P < 0.001) and hair cortisol (B = −0.003, SE = 0.001, P = 0.029). However, in the fully‐adjusted models, both associations were attenuated and only the association with depressive symptoms remained statistically significant (B = −0.015, SE = 0.004, P < 0.001; hair cortisol B = −0.002, SE = 0.001, P = 0.088). Conclusion In a large sample of older adults in England, grip strength was negatively associated with depressive symptoms. Results were inconclusive regarding the association between grip strength and chronic stress. Further research examining the longitudinal relationships between muscular strength and specific aspects of mental health, while also exploring the neurobiological mechanisms underlying these associations, is warranted before recommendations for policy and practice can be made.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of grip strength with depressive symptoms and cortisol in hair: A cross‐sectional study of older adults

Smith

Firth

Grabovac

et al. 2019

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

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“…This is a growing public health problem as age-related decline in physical performance is related to life motivation, quality of life, and nutrition in the elderly [5–10]. …”

Section: Introductionmentioning

confidence: 99%

Associations of low-intensity light physical activity with physical performance in community-dwelling elderly Japanese: A cross-sectional study

et al. 2017

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BackgroundPhysical activity and physical performance relate to quality of life, mortality, and morbidity in elderly people. However, little is known about differences in physical performance related to low-intensity light physical activity (LLPA), high-intensity light physical activity (HLPA), and moderate-intensity physical activity (MPA) and how they are separated by sex in elderly populations.AimsThis study aimed to determine differences in LLPA, HLPA, MPA, and physical performance, and associations between these measures in community-dwelling elderly men and women.MethodsPhysical activity and physical performance such as timed-up-and-go test, one-leg standing time, and maximum gait speed were measured in 181 community-dwelling elderly men (mean age, 75.1 ± 5.3 years) and 109 women (mean age, 73.4 ± 4.8 years) in 2013. Physical activity was classified as LLPA (1.6~1.9 METs of physical activity), HLPA (2.0~2.9 METs of physical activity), and MPA (over 3 METs of physical activity). The association between the values of these three intensities of physical activity in the participants was assessed by Pearson’s correlation coefficients. Multiple linear regression analyses were used to assess the association of physical performance values with the three groups defined by accelerometer-measured physical activity intensity adjusted for sociographic, behavioral, and multiple diseases in the participants.ResultsMPA was beneficially associated with all physical performance indicators in the men (all P<0.05) and women (all P<0.05). Only HLPA showed significant associations with the timed-up-and-go test (P = 0.001) and maximum gait speed (P = 0.006) in women.DiscussionThese results may support the notion that not only HLPA in women but MPA in both sexes appears to improve physical performance in elderly populations.ConclusionThe present study findings provide novel epidemiological evidence for the potential benefits of HLPA in women and also reinforce the potential benefits of MPA in both sexes, which is the mainstay of public health recommendations.

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“…Kekuatan genggam tangan yang rendah berhubungan dengan rendahnya aktivitas fisik sehari-sehari. 36 Penelitian kami tidak melakukan asosiasi IMT dengan kekuatan genggam tangan secara langsung dan tidak melakukan penilaian terhadap aktivitas fisik harian. Akan tetapi, penelitian ini melakukan analisis stratifikasi berdasarkan indeks massa tubuh dan penyesuaian terhadap CCI antara FGF-23 dengan KGT.…”

Section: Diskusiunclassified

Korelasi kadar Fibroblast Growth Factor-23 dengan Kekuatan Genggam Tangan pada Pasien Hemodialisis Dua Kali Seminggu

Lydia¹,

Gaol²,

Suhardjono³

et al. 2020

JPDI

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ABSTRAKPendahuluan. Salah satu faktor utama yang terlibat dalam gangguan mineral tulang dan muskuloskeletal pada pasien penyakit ginjal kronik (PGK) adalah fibroblast growth factor-23 . Peningkatan kadar FGF-23 terjadi pada awal PGK dan semakin meningkat pada PGK tahap akhir terutama yang menjalani dialisis. Fibroblast growth factor-23 perlu mendapat perhatian khusus karena perannya terhadap otot skeletal pada pasien PGK yang menjalani hemodialisis belum diketahui secara pasti. Penelitian ini dilakukan untuk mengetahui korelasi antara kekuatan genggam tangan (KGT) dengan kadar FGF-23 pada pasien yang menjalani hemodialisis dua kali seminggu.Metode. Penelitian ini merupakan studi potong lintang yang dilaksanakan di Unit Hemodialisis Rumah Sakit Dr. Cipto Mangunkusumo Jakarta, pada pasien yang mendapatkan dialisis 2 kali seminggu. Pengukuran FGF dengan pemeriksaan intact fibroblast growth factor-23 (iFGF-23) dan menilai KGT dengan dinamometer hidraulik tangan merek Jamar. Pemilihan subjek dilakukan secara consecutive sampling sampai jumlah subjek yang diperlukan terpenuhi. Hasil.Subjek pada penelitian ini sebanyak 74 subjek dengan kadar pemeriksaan FGF-23 pada laki-laki (median 3.276 pg/ml [rentang 41-6.613 pg/ml]) lebih tinggi dibandingkan dengan perempuan (median 1.585 pg/ml [rentang 21-4.820 pg/ml]). Nilai median KGT pasien laki-laki adalah 25 kg (rentang 11-48 kg), sedangkan pada perempuan adalah 20 kg (rentang 8-26 kg). Setelah dilakukan penyesuaian dengan indeks komorbid charlson modifikasi dan indeks massa tubuh, tidak didapatkan korelasi antara FGF-23 dengan KGT pada subjek laki-laki (r=-0,053, p=0,7), akan tetapi terdapat korelasi negatif bermakna pada subjek perempuan (r=-0,4, p=0,02).Simpulan. Kadar FGF-23 memiliki korelasi negatif bermakna dengan KGT pada perempuan dengan IMT >18,5 kg/m 2 dan hal tersebut tidak ditemukan pada subjek penelitian laki-laki.Kata Kunci: FGF-23, hemodialisis, kekuatan genggam tangan ABSTRACT Introduction. One of the main factors involved in bone mineral and musculoskeletal disorders in patients with chronic kidney disease (CKD) is fibroblast growth factor-23 (FGF-23). Fibroblast growth factor 23 (FGF-23) levels are elevated in hemodialysis patients. Despite FGF-23 associated left ventricular hypertrophy, there are no prior studies assessing whether FGF-23 level is associated with skeletal muscle strength in hemodialysis patient. This study aimed to determine the correlation between hand-grip strength (HGS) and FGF-23 levels in patients undergoing twice weekly hemodialysis patients. Methods. A cross-sectional study was conducted on patients with twice weekly hemodialysis at the Hemodialysis Unit atDr Cipto Mangunkusumo Hospital, Jakarta. We measured intact fibroblast growth factor-23 and hand grip strength that measured by Jamar hydraulic hand dynamometer. Subject selection was done by consecutive sampling until the required number of subjects was fulfilled. Results.A total of 74 subjects were included in this study which serum FGF23 levels were significantly higher in males (...

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Associations between daily physical activity, handgrip strength, muscle mass, physical performance and quality of life in prefrail and frail community-dwelling older adults

Cited by 83 publications

References 43 publications

The association of grip strength with depressive symptoms and cortisol in hair: A cross‐sectional study of older adults

The association of grip strength with depressive symptoms and cortisol in hair: A cross‐sectional study of older adults

Associations of low-intensity light physical activity with physical performance in community-dwelling elderly Japanese: A cross-sectional study

Korelasi kadar Fibroblast Growth Factor-23 dengan Kekuatan Genggam Tangan pada Pasien Hemodialisis Dua Kali Seminggu

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