Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies

Abstract

Background: Coronavirus disease 2019 (COVID-19) is commonly associated with skin manifestations, and may also exacerbate existing skin diseases, yet the relationship between COVID-19 and skin diseases remains unclear.Objective: By investigating this relationship through a multiomics approach, we sought to ascertain whether patients with skin conditions are more susceptible to COVID-19. Methods: We conducted an epidemiological study and then compared gene expression across 9 different inflammatory skin conditions and severe acute respiratory syndrome coronavirus 2-infected bronchial epithelial cell lines, and then performed a genome-wide association study transdisease meta-analysis between COVID-19 susceptibility and 2 skin diseases (psoriasis and atopic dermatitis). Results: Skin conditions, including psoriasis and atopic dermatitis, increase the risk of COVID-19 (odds ratio, 1.55; P 5 1.4 3 10 29 ) but decrease the risk of mechanical ventilation (odds ratio, 0.22; P 5 8.5 3 10 25 ). We observed significant overlap in gene expression between the infected normal bronchial epithelial cells and inflammatory skin diseases, such as psoriasis and atopic dermatitis. For genes that are commonly induced in both the severe acute respiratory syndrome coronavirus 2 infection and skin diseases, there are 4 S100 family members located in the epidermal differentiation complex, and we also identified the ''IL-17 signaling pathway'' (P 5 4.9 3 10 277 ) as one of the most significantly enriched pathways. Furthermore, a shared genome-wide significant locus in the epidermal differentiation complex was identified between psoriasis and severe acute respiratory syndrome coronavirus 2 infection, with the lead marker being a significant expression quantitative trait locus for S100A12 (P 5 3.3 3 10 27 ). Conclusions: Together our findings suggest association between inflammatory skin conditions and higher risk of COVID-19, but with less severe course, and highlight shared components involved in anti-COVID-19 immune response.

Atopic dermatitis is not associated with SARS-CoV-2 outcomes

“…These findings are consistent with studies that found no association of AD with COVID-19 morbidity. AD patients may be more susceptible to acquiring SARS-CoV-2 infection [3], though findings are inconclusive [5]. Current evidence indicates that AD patients are not at increased risk of mechanical ventilation [3,4], hospitalization [2], longer hospital stay [4], intensive care unit admission [4] or death [2,4].…”

“…AD patients may be more susceptible to acquiring SARS-CoV-2 infection [3], though findings are inconclusive [5]. Current evidence indicates that AD patients are not at increased risk of mechanical ventilation [3,4], hospitalization [2], longer hospital stay [4], intensive care unit admission [4] or death [2,4]. In one retrospective study, AD was inversely associated with COVID-19 hospitalization [1].…”

“…asthma and rhinitis. Concern exists regarding potential for poorer COVID-19 outcomes in AD patients, though previous studies had mixed findings [1][2][3][4][5]. We investigated the relationship between AD and COVID-19 outcomes in adults.…”

A comprehensive review of the analysis and integration of omics data for SARS-CoV-2 and COVID-19

“…For example, Patrick et al . suggested an association between inflammatory skin conditions and higher risk of COVID-19, in which the Severe COVID-19 GWAS Group was excluded [ 126 ]. For COVID-19 transcriptomics data, for instance, Muus et al .…”

Vaccines Against SARS-CoV-2 in Psoriasis Patients on Immunosuppressive Therapy: Implications of Vaccination Nationwide Campaign on Clinical Practice in Italy

“…An important study investigating the relationship between psoriasis and COVID-19 infection is that conducted by Patrick et al [ 32 ]. These authors performed an epidemiological analysis of 435,019 patients managed in Michigan Medicine (formerly the University of Michigan Health System) who had at least one health system encounter between 1 January 2019, and 20 June 2020 and then compared gene expression across nine different inflammatory skin conditions, including psoriasis, and SARS-CoV2-infected bronchial epithelial cell lines.…”