Associations between clinical characteristics and chronic complications in latent autoimmune diabetes in adults and type 2 diabetes

Section: Discussioncontrasting

confidence: 66%

“…Previous studies have confirmed that metabolic syndrome is prevalent in LADA patients; however, it is less prevalent compared with T2D patients. 14 24 Analysis of the data in E-LADA patients stratified by GADA titre showed that more components of metabolic syndrome were evident in E-LADA patients with low titre of GADA.…”

Section: Discussionmentioning

confidence: 99%

Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8

Niu

Luo

et al. 2018

“…It also reported that more LADA patients required insulin therapy . Furthermore, our previous study showed a lower prevalence of microvascular complications in LADA in the early stage of diabetes . In this study, different levels of systolic blood pressure, BMI, FCP, TG and HDL‐C were also observed among patients with type 1 DM, LADA, type 2 DM and controls.…”

Section: Discussionsupporting

confidence: 66%

Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults

Lü

Hou

Pang

et al. 2016

Self Cite

Aims This study aimed to compare pancreatic volume and its clinical significance among patients with type 2 diabetes mellitus (DM), adult-onset type 1 DM and latent autoimmune diabetes in adults (LADA).Methods This is a cross-sectional study. One hundred twenty-six outpatients (68 with LADA and 58 with type 1 DM) and 158 inpatients (71 with type 2 DM and 87 non-diabetic controls) were recruited during May-July 2013 in Shanghai Jiao Tong University Affiliated Sixth People's Hospital. All the patients underwent abdominal computerized tomography; pancreatic volume was then calculated.Results The mean pancreatic volume was highest in the controls, followed by those in patients with type 2 DM, LADA and type 1 DM. The pancreatic volume in LADA was comparable with that in type 2 DM but significantly greater than that in type 1 DM (p < 0.05). The pancreatic volume in patients with LADA was significantly correlated with sex, waist circumference, body surface area, body mass index, diastolic blood pressure and high-density lipoprotein cholesterol (all p < 0.05). The correlation between pancreatic volume and fasting C-peptide was high in patients with LADA (r = 0.643, p < 0.001) and moderate in patients with type 2 DM (r = 0.467, p < 0.001). The area under the receiver operating characteristic curve for pancreatic volume predictive of absolute insulin deficiency (FCP < 0.9 ng/mL) was 0.85 (0.76-0.94) in LADA.Conclusions Pancreatic atrophy in LADA was less marked than in type 1 DM. Pancreatic atrophy may suggest reduced level of fasting C-peptide in patients with LADA.

“…Participants were grouped into having LADA (n = 15, 12 men and 3 women) or type 1 diabetes (n = 15, 7 men and 8 women). Subgrouping of participants into LADA was based on the criteria suggested by the Immunology of Diabetes Society: age of onset after 30 years of age, the presence of at least one circulating autoantibody mentioned above, and insulin independence for the first 6 months after disease onset, as seen in other studies of LADA . A type 2 diabetes cohort (n = 23, 11 men, 12 women) and a cohort of age‐matched healthy control participants (n = 26, 11 men, 15 women) were also recruited.…”

Section: Methodsmentioning

confidence: 99%

“…12 Society: age of onset after 30 years of age, the presence of at least one circulating autoantibody mentioned above, and insulin independence for the first 6 months after disease onset, as seen in other studies of LADA. 13,14 A type 2 diabetes cohort (n = 23, 11 men, 12 women) and a cohort of age-matched healthy control participants (n = 26, 11 men, 15 women) were also recruited. Required cohort sizes were determined from changes in nerve excitability parameters observed in previous studies of participants with diabetes and were calculated at 80% power, with an α = .05.…”

mentioning

confidence: 99%

Altered peripheral nerve structure and function in latent autoimmune diabetes in adults

Issar

Yan

Kwai

et al. 2019

Aim The present study was undertaken to investigate mechanisms of peripheral nerve dysfunction in latent autoimmune diabetes in adults (LADA). Materials and methods Participants with LADA (n = 15) underwent median nerve ultrasonography and nerve excitability to examine axonal structure and function, in comparison to cohorts of type 1 diabetes (n = 15), type 2 diabetes (n = 23) and healthy controls (n = 26). The LADA group was matched for diabetes duration, glycaemic control, and neuropathy severity with the type 1 and type 2 diabetes groups. A validated mathematical model of the human axon was utilized to investigate the pathophysiological basis of nerve dysfunction. Results The most severe changes in nerve structure and function were noted in the LADA group. The LADA cohort demonstrated a significant increase in nerve cross‐sectional area compared to type 1 participants and controls. Compared to type 1 and 2 diabetes, measures of threshold electrotonus, which assesses nodal and internodal conductances, were significantly worse in LADA in response to both depolarising currents and hyperpolarising currents. In the recovery cycle, participants with LADA had a significant increase in the relative refractory period. Mathematical modelling of excitability recordings indicated the basis of nerve dysfunction in LADA was different to type 1 and 2 diabetes. Conclusions Participants with LADA exhibited more severe changes in nerve function and different underlying pathophysiological mechanisms compared to participants with type 1 or 2 diabetes. Intensive management of risk factors to delay the progression of neuropathy in LADA may be required.