Associations between cerebral blood flow and structural and functional brain imaging measures in individuals with neuropsychologically defined mild cognitive impairment

Kim, Chan Mi; Alvarado, Rachel L.; Stephens, Kimberly A.; Wey, Hsiao‐Ying; Wang, Danny J.J.; Leritz, Elizabeth C.; Salat, David H.

doi:10.1016/j.neurobiolaging.2019.10.023

Cited by 47 publications

(43 citation statements)

References 131 publications

(128 reference statements)

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“…Seven of the 27 new cross-sectional studies reported only the results of association analyses, and did not provide quantitative data for CBF or WMH measurements. Patient groups in these studies included patients with acute stroke, 12, 31 MCI, 32 vascular depression 33 , individuals at varying risk of cerebrovascular disease 34 and older individuals with WMH. 17, 35…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies used ASL 6-8, 10, 14, 15, 19, 20, 25, 27, 30, 32, 34-36 , 3 used CT perfusion 18, 28, 29 , 2 used dynamic susceptibility contrast (DSC) MRI 9, 37 , one study each used SPECT 21 , phase contrast MRI 22 , CT angiography/digital subtraction angiography, 31 PET, 23 and a combination of CT and DSC MRI 12 . Five studies used transcranial Doppler ultrasound 16, 17, 24, 26, 33 .…”

Section: Resultsmentioning

confidence: 99%

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Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis

Stewart

Stringer

Shi

et al. 2020

Preprint

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Cerebral small vessel disease is a major contributor to stroke and dementia, characterised by white matter hyperintensities (WMH) on neuroimaging. WMH are associated with reduced cerebral blood flow (CBF) cross-sectionally, though longitudinal associations remain unclear. We updated a 2016 meta-analysis, identifying 30 studies, 27 cross-sectional (n=2956) and 3 longitudinal (n=440), published since 2016. Cross-sectionally, we meta-analysed 10 new studies with 24 previously reported studies, total 34 (n=2180), finding lower CBF to be associated with worse WMH burden (mean global CBF: standardised mean difference: -0.45, 95% confidence interval (CI): -0.64,-0.27). Longitudinally, the association of baseline CBF with WMH progression varied: the largest study (5 years, n=252) found no associations, while another small study (4.5 years, n=52) found that low CBF in the periventricular WMH penumbra predicted WMH progression. We could not meta-analyse longitudinal studies due to different statistical and methodological approaches. We found lower CBF within WMH compared to normal appearing white matter (novel meta-analysis; 5 cross-sectional studies; n=295; SMD: -1.51, 95% CI: -1.94,-1.07). These findings highlight that relationships between resting CBF and WMH are complex and that more longitudinal studies analysing regional CBF and subsequent WMH change are required to determine the role of CBF in small vessel disease progression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis

Stewart

Stringer

Shi

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…The decline in CBF values may reflect neuronal dysfunction and synaptic failure (Hays et al, 2016 ). A controversy remains regarding whether the CBF values measured by ASL show hypoperfusion or hyperperfusion patterns in SCD or MCI, and the hypoperfusion/hyperperfusion areas may involve different brain regions simultaneously (Alexopoulos et al, 2012 ; Bron et al, 2014 ; Leeuwis et al, 2017 ; Chau et al, 2020 ; Kim et al, 2020 ). Compared with those of ECs, we found decreased MK values in the bilateral Hip (h), left PCC, left DT (a), and left OLWM and increased MK values in the left Pr in participants with SCD plus.…”

Section: Discussionmentioning

confidence: 99%

Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

Yang

Cao

et al. 2021

Front. Aging Neurosci.

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Objective: To explore microstructural and cerebral blood flow (CBF) abnormalities in individuals with subjective cognitive decline plus (SCD plus) using diffusional kurtosis imaging (DKI) and three-dimensional (3D) arterial spin labeling (ASL).Methods: Twenty-seven patients with SCD plus, 31 patients with amnestic mild cognitive impairment (aMCI), and 33 elderly controls (ECs) were recruited and underwent DKI and 3D ASL using a GE 3.0-T MRI. Mean kurtosis (MK), fractional anisotropy (FA), mean diffusivity (MD), and CBF values were acquired from 24 regions of interest (ROIs) in the brain, including the bilateral hippocampal (Hip) subregions (head, body, and tail), posterior cingulate cortex (PCC), precuneus, dorsal thalamus subregions (anterior nucleus, ventrolateral nucleus, and medial nucleus), lenticular nucleus, caput nuclei caudati, white matter (WM) of the frontal lobe, and WM of the occipital lobe. Pearson's correlation analysis was performed to assess the relationships among the DKI-derived parameters, CBF values, and key neuropsychological tests for SCD plus.Results: Compared with ECs, participants with SCD plus showed a significant decline in MK and CBF values, mainly in the Hip head and PCC, and participants with aMCI exhibited more significant abnormalities in the MK and CBF values than individuals with ECs and SCD plus in multiple regions. Combined MK values showed better discrimination between patients with SCD plus and ECs than that obtained using CBF levels, with areas under the receiver operating characteristic (ROC) curve (AUC) of 0.874 and 0.837, respectively. Similarly, the AUC in discriminating SCD plus from aMCI patients obtained using combined MK values was 0.823, which was also higher than the combined AUC of 0.779 obtained using CBF values. Moreover, MK levels in the left Hip (h) and left PCC positively correlated with the auditory verbal learning test-delayed recall (AVLT-DR) score in participants with SCD plus. By contrast, only the CBF value in the left Hip head positively correlated with the AVLT-DR score.Conclusions: Our results provide new evidence of microstructural and CBF changes in patients with SCD plus. MK may be used as an early potential neuroimaging biomarker and may be a more sensitive DKI parameter than CBF at the very early stage of Alzheimer's disease (AD).

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“…A chronic decline in sustained cerebral blood flow is the main mechanism underlying the development of vascular cognitive impairment (VCI) (Kazumata et al, 2019;Kim et al, 2019;Mansour et al, 2019;McKetton et al, 2019). Thus, animal models of chronic cerebral hypoperfusion are most commonly used to study VCI (Duncombe et al, 2017;Mansour et al, 2018;Washida et al, 2019).Therefore, our future studies aim to combine age factors with chronic cerebral hypoperfusion allowing the exploration of changes in the white matter and cognitive functions in elderly rats under different degrees of hypoperfusion and to establish a new VCI model of elderly rats with bilateral common carotid artery (CCA) stenosis (BCAS).…”

Section: Introductionmentioning

confidence: 99%

A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment

Wang

Yang

Wang

et al. 2020

Front. Aging Neurosci.

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Associations between cerebral blood flow and structural and functional brain imaging measures in individuals with neuropsychologically defined mild cognitive impairment

Cited by 47 publications

References 131 publications

Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis

Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis

Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment

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