2003
DOI: 10.1152/physiolgenomics.00165.2002
|View full text |Cite
|
Sign up to set email alerts
|

Associations between cardiorespiratory responses to exercise and the C34TAMPD1gene polymorphism in the HERITAGE Family study

Abstract: The associations of the C34T polymorphism of the adenosine monophosphate deaminase 1 (AMPD1) gene with cardiorespiratory phenotypes were tested during cycling exercise at absolute and relative power outputs progressing to exhaustion before and after endurance training for 20 wk in the HERITAGE Family Study cohort (n = 779). Since no blacks were mutant homozygotes (TT), only whites were considered for analysis (400 normal homozygotes, CC; 97 heterozygotes, CT; and 6 TT). For sedentary state, cycling at the abso… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

9
77
1
5

Year Published

2007
2007
2022
2022

Publication Types

Select...
5
3
1

Relationship

0
9

Authors

Journals

citations
Cited by 85 publications
(92 citation statements)
references
References 35 publications
9
77
1
5
Order By: Relevance
“…In this study, there was no significant association between genotypes and BMI, which is in agreement with previous studies (Rico-Sanz et al, 2003;Kolek et al, 2005;Agewall and Norman, 2006;Collins et al, 2006). In addition, we did not observe a significant association between genotypes and the level of FBS.…”
Section: Discussionsupporting
confidence: 92%
“…In this study, there was no significant association between genotypes and BMI, which is in agreement with previous studies (Rico-Sanz et al, 2003;Kolek et al, 2005;Agewall and Norman, 2006;Collins et al, 2006). In addition, we did not observe a significant association between genotypes and the level of FBS.…”
Section: Discussionsupporting
confidence: 92%
“…However, despite numerous reports of exerciseinduced cramping, pain and early fatigue in mAMPD-deWcient individuals, the high prevalence of AMPD1 mutations in the general population indicates relatively more asymptomatic mAMPD-deWcient individuals (Norman et al 1995(Norman et al , 2001Rico-Sanz et al 2003;Sabina et al 1984;Verzijl et al 1998). This Wnding lends little support to the proposed causal relationship between mAMPD deWciency and myopathic symptoms.…”
Section: Introductionmentioning
confidence: 87%
“…This Wnding lends little support to the proposed causal relationship between mAMPD deWciency and myopathic symptoms. Nevertheless, several recent studies have shown diminished exercise performance in asymptomatic individuals with an inherited mAMPD deWciency (De Ruiter et al 2002;Fischer et al 2007;Rico-Sanz et al 2003), which does indicate a physiological role for this enzyme in skeletal muscle.…”
Section: Introductionmentioning
confidence: 99%
“…Rubio és munkatársai megfigyelték, hogy a T allél gyakorisága kisebb volt az álta-luk vizsgált kerékpárosok és futók körében, mint a nem sportoló kontrollpopulációban [37]. Rico-Sanz és munkatársai több teljesítmény-élettani mutatóban is különbséget fedeztek fel a különböző AMPD genotípusú személyek között [38]. Az AMPD-variánsok így a teljesítményt befolyásoló kandidáns locusok közé sorolhatóak.…”
Section: Az áLlóképességet éS Az Izomerőt Befolyásoló További Génváltunclassified