Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty

Li, Chunmei; Chen, Yuhui; Wu, Pu-Yeh; Wu, Bing; Gong, Tao; Wang, Hua; Chen, Min

doi:10.21037/qims-20-852

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…The MoCA scale is currently the most used scale for determining cognitive impairment, showing high sensitivity in detecting early cognitive changes in various cognitive domains, with high sample heterogeneity and detection rate ( 40 , 41 ). While the EFS scale has been widely used in the clinical frail assessment of the older adults with good structural validity, reliability, and internal consistency ( 42 , 43 ). Therefore, the combinational assessment of cognitive ability and physical frailty can comprehensively express the CF status of an older person ( 44 , 45 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Baduanjin exercise on cognitive frailty, oxidative stress, and chronic inflammation in older adults with cognitive frailty: a randomized controlled trial

Ye,

Wan,

Lin

et al. 2024

Front. Public Health

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BackgroundOxidative stress and chronic inflammation play an important role in the pathogenesis process of cognitive frailty (CF). Regular Baduanjin exercise could improve cognitive frailty in older adults, but it is unclear whether the effect of Baduanjin exercise on improving CF is mediated by modulating circulating oxidative stress and inflammatory process.MethodA total of 102 community-dwelling older adults with CF were recruited and randomly allocated into a 24-week Baduanjin exercise training group or no specific exercise intervention control group at an equal rate. Cognitive function and physical frailty index were assessed using the Montreal Cognitive Assessment (MoCA) and the Edmonton Frail Scale (EFS), as well as the oxidative stress and inflammatory cytokines were measured at baseline and after intervention.ResultAfter 24 weeks of intervention, the increased MoCA score (2.51 ± 0.32 points, p < 0.001) and the decreased EFS scores (1.94 ± 0.20 points, p = 0.012) in the Baduanjin group were significantly higher than those in the control group. Serum antioxidant SOD levels were increased by 10.03 ± 4.73 U/mL (p < 0.001), and the prooxidative MDA and 8-iso-PGF2α levels were decreased by −1.08 ± 0.80 nmol/mL (p = 0.030) and −86.61 ± 15.03 ng/L (p < 0.001) in the Baduanjin training group; while inflammatory cytokines IFN-γ, IL-2 and IL-4 levels were increased (1.08 ± 0.33 pg./mL, p = 0.034, 2.74 ± 0.75 pg./mL, p = 0.04 and 1.48 ± 0.35 pg./mL, p = 0.042). In addition, a mediation effect that Baduanjin training improved cognitive ability mediated by an increase of circulating IFN-γ and IL-2 levels were observed in this study.ConclusionRegular Baduanjin exercise training could improve the cognitive frailty of the community-dwelling older adults with CF, and modulate oxidative stress and inflammatory processes by reducing circulating pro-oxidative MDA and 8-iso-PGF2α levels and increasing anti-oxidative SOD levels, as well as impacting inflammatory cytokines IFN-γ, IL-2, and IL-4 levels. Nevertheless, the mechanism of Baduanjin exercise mediating oxidative stress and inflammatory processes should be cautious to be explained.Clinical trial registrationhttp://www.chictr.org.cn/index.aspx, ChiCTR1800020341.

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Section: Discussionmentioning

confidence: 99%

Effects of Baduanjin exercise on cognitive frailty, oxidative stress, and chronic inflammation in older adults with cognitive frailty: a randomized controlled trial

Ye,

Wan,

Lin

et al. 2024

Front. Public Health

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“…The whole-brain T1, T2, and proton density (PD) values of each patient were automatically extracted based on the anatomical labeling gray matter template and the Johns Hopkins University White Matter Template using an in-house code embedded in MATLAB 2013b (V8.2.0.701) after MAGiC data were affined to 3D T1-weighted imaging using affine parameters of 3D T1-weighted images to rigidly register, segment, and normalize into a Montreal Neuroscience Institute space. Detailed brain region information is provided in Additional file 2: Table S1 [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection

Du,

Li,

Zhao

et al. 2024

BMC Med

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Background To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with those in exacerbated chronic insomnia in Omicron patients, and to examine individuals without insomnia alongside those with new-onset insomnia. Methods In this study, a total of 135 participants were recruited between January 11 and May 4, 2023, including 26 patients with chronic insomnia without exacerbation, 24 patients with chronic insomnia with exacerbation, 40 patients with no sleep disorder, and 30 patients with new-onset insomnia after infection with Omicron (a total of 120 participants with different sleep statuses after infection), as well as 15 healthy controls who were never infected with Omicron. Neuropsychiatric data, clinical symptoms, and multimodal magnetic resonance imaging data were collected. The gray matter thickness and T1, T2, proton density, and perivascular space values were analyzed. Associations between changes in multimodal magnetic resonance imaging findings and neuropsychiatric data were evaluated with correlation analyses. Results Compared with healthy controls, gray matter thickness changes were similar in the patients who have and do not have a history of chronic insomnia groups after infection, including an increase in cortical thickness near the parietal lobe and a reduction in cortical thickness in the frontal, occipital, and medial brain regions. Analyses showed a reduced gray matter thickness in patients with chronic insomnia compared with those with an aggravation of chronic insomnia post-Omicron infection, and a reduction was found in the right medial orbitofrontal region (mean [SD], 2.38 [0.17] vs. 2.67 [0.29] mm; P < 0.001). In the subgroups of Omicron patients experiencing sleep deterioration, patients with a history of chronic insomnia whose insomnia symptoms worsened after infection displayed heightened medial orbitofrontal cortical thickness and increased proton density values in various brain regions. Conversely, patients with good sleep quality who experienced a new onset of insomnia after infection exhibited reduced cortical thickness in pericalcarine regions and decreased proton density values. In new-onset insomnia patients post-Omicron infection, the thickness in the right pericalcarine was negatively correlated with the Self-rating Anxiety Scale (r = − 0.538, P = 0.002, PFDR = 0.004) and Self-rating Depression Scale (r = − 0.406, P = 0.026, PFDR = 0.026) scores. Conclusions These findings help us understand the pathophysiological mechanisms involved when Omicron invades the nervous system and induces various forms of insomnia after infection. In the future, we will continue to pay attention to the dynamic changes in the brain related to insomnia caused by Omicron infection.

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“…The whole-brain T1, T2 and proton density (PD) values of each patient were automatically extracted based on the anatomical labeling (AAL) gray matter template and the Johns Hopkins University (JHU) White Matter Template using an in-house code embedded in MATLAB 2013b (V8.2.0.701) after MAGiC data were a ned to 3D T1-weighted imaging using a ne parameters of 3D T1-weighted images to rigidly register, segment and normalize into an MNI template (Montreal Neuroscience Institute space). Detailed brain region information is provided in Supplementary Material 2 11 .…”

Section: Magicmentioning

confidence: 99%

Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection in individuals with chronic insomnia and healthy individuals

Liu,

Du,

et al. 2023

Preprint

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IMPORTANCE Whether the mechanism of nervous system invasion and the brain regions targeted by the currently prevalent Omicron strain parallel those of the Delta strain is unclear. Insomnia is a prevalent and persistent issue following Delta variant infection, yet our comprehension of the connection between Omicron strains and insomnia remains limited. OBJECTIVE To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with those in exacerbated chronic insomnia in Omicron patients and to examine individuals without insomnia alongside those with new-onset insomnia. DESIGN, SETTING, AND PARTICIPANTS In this cohort study, a total of 135 participants were recruited between January 11 and May 4, 2023, including 120 participants with different sleep statuses after infection with Omicron and 15 healthy controls. Neuropsychiatric data, clinical symptoms, and multimodal magnetic resonance imaging data were collected. The gray matter thickness and T1, T2, proton density, and perivascular space values were analyzed. Associations between changes in multimodal magnetic resonance imaging findings and neuropsychiatric data were evaluated with correlation analyses. EXPOSURES Gray matter thickness was evaluated based on the neurological alterations induced by Omicron infection, and multimodal magnetic resonance imaging was used to explore the effects of Omicron infections on sleep patterns in various populations. MAIN OUTCOMES AND MEASURES Neuropsychiatric scale scores were evaluated by using IBM SPSS Statistics 24.0. Gray matter thickness and T1, T2, proton density, and perivascular space values were calculated from three-dimensional magnetization-prepared rapid acquisition gradient echo, magnetic resonance image compilation and diffusion tensor imaging sequences, respectively, using image data analysis software. RESULTS Compared with healthy controls, patients with chronic insomnia, aggravation of chronic insomnia, and new-onset insomnia had significantly higher Self-rating Anxiety Scale and Self-rating Depression Scale scores post-Omicron infection. Compared with healthy controls, the gray matter thickness was significantly reduced in the left medial orbitofrontal, lingual, pericalcarine and right lateral occipital lobes and significantly increased in the left inferior parietal and right superior parietal lobes in the patients with chronic insomnia post-Omicron infection. The individuals with good sleep quality had no change in sleep status after infection; significantly reduced gray matter thickness of the left medial orbitofrontal, cuneus, lingual and right pericalcarine; and increased gray matter thickness in the left inferior parietal, supramarginal, and bilateral superior parietal regions compared with healthy controls. Analyses showed a reduced gray matter thickness in patients with chronic insomnia compared with those with an aggravation of chronic insomnia post-Omicron infection, and a reduction was found in the right medial orbitofrontal region (mean [SD], 2.38 [0.17] vs. 2.67 [0.29] mm; P < 0.001). Compared with patients with chronic insomnia, patients with an aggravation of chronic insomnia post-Omicron infection showed a significant decrease in T1 values (left occipital and right olfactory and temporal lobes) and an increase in T2 values (left occipital and parietal and right precuneus lobes) and proton density values (bilateral frontal and right occipital and precuneus lobes). New-onset insomnia patients showed reduced gray matter thickness in the right pericalcarine (mean [SD], 1.62 [0.16] vs. 1.50 [0.15] mm; P < 0.001), and they had significantly decreased proton density values (right lingual, fusiform, parietal and temporal lobes) compared to individuals with good sleep quality, who showed no change in sleep status after infection. In new-onset insomnia patients post-Omicron infection, the thickness in the right pericalcarine was negatively correlated with the Self-rating Anxiety Scale (r = -0.538, P = 0.002, PFDR = 0.004) and Self-rating Depression Scale (r = -0.406, P = 0.026, PFDR = 0.026) scores. CONCLUSIONS AND RELEVANCE In summary, changes in gray matter thickness after Omicron infection were similar in chronic insomnia patients and healthy people, but there were significant differences in gray matter thickness and T1, T2, and proton density values in patients with different sleep qualities. These findings help us understand the pathophysiological mechanisms involved when Omicron invade the nervous system and induce various forms of insomnia after infection. In the future, we will continue to pay attention to the dynamic changes in the brain related to insomnia caused by Omicron infection.

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Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty

Cited by 4 publications

References 44 publications

Effects of Baduanjin exercise on cognitive frailty, oxidative stress, and chronic inflammation in older adults with cognitive frailty: a randomized controlled trial

Effects of Baduanjin exercise on cognitive frailty, oxidative stress, and chronic inflammation in older adults with cognitive frailty: a randomized controlled trial

Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection

Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection in individuals with chronic insomnia and healthy individuals

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