Associations Between Bone Mineral Density and Subclinical Atherosclerosis: A Cross-Sectional Study of a Chinese Population

Liang, Dongke; Bai, Xia; Wu, Bing; Han, Lulu; Wang, Xiaonan; Jun, Yang; Chen, Xiangmei

doi:10.1210/jc.2013-2572

Cited by 37 publications

(36 citation statements)

References 37 publications

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“…In a multiethnic study performed in the USA, low lumbar spine BMD was not associated with CIMT in men or women [3]. Similar results have been reported in China [12, 13, 15] and Korea [31]. In addition, Beer et al [33] reported that low hip BMD was not associated with angiographically determined coronary atherosclerosis in men, consistent with our results.…”

Section: Discussionsupporting

confidence: 91%

“…These studies were limited by their poor representativeness of the general population and inability to adjust for many proposed confounding factors. Nevertheless, a community-based survey conducted in northeastern China reported no association between total hip and lumbar spine BMD and baPWV in women or men, which is supported by our results [13]. …”

Section: Discussionsupporting

confidence: 88%

“…Little evidence exists to confirm an association between BMD and multiple indices of subclinical atherosclerosis. Some of these studies have even shown inconsistent results [13, 15]. …”

Section: Introductionmentioning

confidence: 99%

“…In addition, little information about the association between BMD and subclinical atherosclerosis is available in the Asian population, especially in China, and some conclusions drawn in this population have been inconsistent and contradictory [7, 12, 13, 15, 22, 23]. Studies involving Asian participants have mainly focused on urban residents or the hospital health screening population.…”

Section: Introductionmentioning

confidence: 99%

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Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

et al. 2018

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Objectives: Loss of bone mass may affect the progression of atherosclerosis. We investigated the relationship between low bone mineral density (BMD) and subclinical atherosclerosis in rural China. Methods: In total, 333 men and 421 postmenopausal women aged 55–65 years were enrolled. BMD was measured in the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. Subclinical atherosclerosis was defined as increased carotid artery intima-media thickness (CIMT ≥0.9 mm), the presence of carotid plaques, high brachial-ankle pulse wave velocity (baPWV ≥1,400 cm/s), and low ankle-brachial index (ABI ≤1). Binary logistic regression analyses were used to estimate the association between low BMD and subclinical atherosclerosis. Results: There was no significant difference in BMD between the normal group and the subclinical atherosclerosis group. After full adjustment for the relevant covariates, a boundary significant association was found between low BMD in the femoral neck and baPWV in postmenopausal women (odds ratio = 1.77, p = 0.049). After full adjustment, neither BMD nor low BMD were significantly associated with subclinical atherosclerosis in men or postmenopausal women. Conclusions: Low BMD is not associated with subclinical atherosclerosis in Chinese individuals aged 55–65 years resident in rural China.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

“…Little evidence exists to confirm an association between BMD and multiple indices of subclinical atherosclerosis. Some of these studies have even shown inconsistent results [13, 15]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

et al. 2018

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“…Liang et al observed in postmenopausal women from the Chinese population that serum creatinine was higher in osteoporotic group compared to osteopenic group similar to this study. They observed negative correlation of serum creatinine with bone mineral density [32]. Klawansky et al observed the significant…”

Section: Discussionmentioning

confidence: 95%

Biochemical Alterations in Postmenopausal Women Having Osteoporic Risk

Sharma

2017

Asian J Pharm Clin Res

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Objective: Osteoporosis is the most common disease worldwide; nutritional factors may play a significant role in the progression of the disease. The aim of this study was to assess the various biochemical parameters in the postmenopausal women with osteoporosis or osteopenia. Methods:In this hospital-based study, total 70 postmenopausal women, 45-80 years of age group, were studied. They were categorized into two groups as Case I and Case II on the basis of diagnosis of osteoporosis and osteopenia, respectively. The bone mineral density using T-score was estimated for diagnosis of osteoporosis or osteopenia. Bone mineral markers, i.e., total calcium and ionized calcium (CAI) were estimated by colorimetric method. Serum phosphate was estimated by direct method, and alkaline phosphatase (ALP) was measured by kinetic method. Biochemical parameters, i.e., urea, were estimated by diacetyl monoxime method. Serum albumin and serum creatinine were measured by bromocresol green method and Jaffe's method, respectively. Serum uric acid and magnesium were estimated by colorimetric method. Results:Total calcium and CAI were significant (<0.05) between the groups. The levels of serum phosphate and ALP were higher in osteoporotic group, but the results were not significant between the groups. Serum urea and serum albumin were comparatively higher and lower in osteoporotic group, respectively, but the findings were not significant between the groups. The significant results of serum creatinine, serum uric acid, and serum magnesium were obtained while comparing between osteoporotic patients and osteopenia patients. The levels were higher in osteoporosis group. There was a negative association of ALP with serum calcium and negative association with serum phosphate and uric acid. Conclusion:Biochemical alterations are characterized in osteoporotic as well as osteopenic patients. Monitoring of these parameters may be beneficial while giving the treatment to these patients for the prevention of other life-threatening risks.

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Comparative study of the correlation between atherosclerosis and osteoporosis in women in Japan and Mongolia

Fujihara¹,

Nawata²,

Honda³

et al. 2017

J of Gen and Family Med

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ObjectiveAssociations between vascular calcification and osteoporosis are well documented, yet effects of lifestyle on atherosclerosis and osteoporosis remain unclear. This study evaluated the relationship between atherosclerosis and osteoporosis of people with different lifestyles living on Uku Island in Japan (rice consumption and fishing lifestyle) and in Ulaanbaatar in Mongolia (meat consumption and nomadic lifestyle), and investigated the differences of lifestyles on atherosclerosis and osteoporosis.MethodsParticipants were women aged over 50 years who had undergone a previous medical examination for atherosclerosis and osteoporosis (Uku Island, 104, Ulaanbaatar, 71). Lifestyle habits were obtained by questionnaire. Bone mineral density of the right calcaneus was measured using quantitative ultrasound. Brachial‐ankle pulse wave velocity was measured as an index of atherosclerosis.ResultsThere were no significant differences in bone mineral density and brachial‐ankle pulse wave velocity between the two groups, even though meat and dairy intake, number of meals skipped, and number of children were significantly greater in participants from Ulaanbaatar compared with Uku Island. Brachial‐ankle pulse wave velocity showed significant positive correlations with age, systolic and diastolic blood pressures, and body mass index and a significant negative correlation with bone mineral density for both groups. With step‐wise multiple regression analysis, brachial‐ankle pulse wave velocity significantly correlated with age and bone mineral density for both populations. Systolic blood pressure significantly correlated with brachial‐ankle pulse wave velocity for the Ulaanbaatar group.ConclusionsDespite significant lifestyle differences, similar relationships between atherosclerosis and osteoporosis were observed in women from Uku Island and Ulaanbaatar. Hypertension was a significant contributing factor for atherosclerosis for the Ulaanbaatar group.

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Associations Between Bone Mineral Density and Subclinical Atherosclerosis: A Cross-Sectional Study of a Chinese Population

Abstract: Low BMD is not associated with subclinical atherosclerosis as assessed by ABI, PWV, and CIMT.

Cited by 37 publications

References 37 publications

Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

Biochemical Alterations in Postmenopausal Women Having Osteoporic Risk

Comparative study of the correlation between atherosclerosis and osteoporosis in women in Japan and Mongolia

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