Associations between Body Mass Index and Chronic Atrophic Gastritis and Intestinal Metaplasia

Abstract

Background/Aims: Chronic atrophic gastritis (AG) and intestinal metaplasia (IM) of the stomach are premalignant lesions. The present study aimed to examine the associations between obesity and these lesions. Methods: A total of 2,997 patients, who underwent gastroscopy, participated in this study, excluding those who had been diagnosed with gastric cancer. Participants were divided into four groups based on their body mass index (BMI). The risk of AG and IM with increasing BMI was analyzed in men and women, separately. Results: The association between BMI and AG was not significant. After adjusting for age, smoking, alcohol, and AG, the odds ratios for IM in the overweight, obesity, and severe obesity groups were 2.25 (95% confidence interval [CI], 1.50-3.37), 2.32 (95% CI, 1.58-3.42), and 4.86 (95% CI, 2.04-11.5) in men, and 2.66 (95% CI, 1.29-5.47), 4.46 (95% CI, 2.28-8.75), and 9.57 (95% CI, 3.26-28.12) in women, compared with the normal BMI group. Conclusions: Gastric IM was significantly associated with increased BMI. (Korean J Gastroenterol 2017;70:81-88)

Body Mass Index and Risk of Intestinal Metaplasia: A Cohort Study

“…Another cross-sectional study of 617 Japanese individuals showed lower BMI in the atrophic gastritispositive group ascertained by the PG I and PG I/II ratio than in the atrophic gastritis-negative group (23). A cross-sectional study of 217 patients demonstrated an inverse association between BMI and biopsy-proven intestinal metaplasia (24 (25). In the same study, there was no significant association between BMI and atrophic gastritis (25).…”

“…A cross-sectional study of 217 patients demonstrated an inverse association between BMI and biopsy-proven intestinal metaplasia (24 (25). In the same study, there was no significant association between BMI and atrophic gastritis (25). In another large-scale retrospective study of 60,261 Korean adults, obesity was significantly associated with endoscopically diagnosed precancerous lesions including atrophic gastritis and intestinal metaplasia, with a multivariable adjusted OR (95% CI) of 1.10 (1.01-1.18; ref.…”

“…The effect of obesity on precursor lesions such as atrophic gastritis or intestinal metaplasia has also been examined in several observational studies, but results are inconclusive. Some studies reported a positive association between BMI and atrophic gastritis or intestinal metaplasia, whereas others reported no association (21)(22)(23)(24)(25)(26)(27). However, previous studies used cross-sectional design, limiting their ability to establish the temporal relationship between obesity and atrophic gastritis or intestinal metaplasia.…”

Multiple Organ Lesions in a Case of Contamination With Multiple Radionuclides After 38 Years

“…But there are many causes of polyps, including chronic intestinal inflammation, aging, abnormal development of immature embryos, low intake of fiber foods, genetic factors, and so on. 21,22 Endoscopic examination revealed gastritis, intestinal metaplasia, and multiple colorectal polyps. However, whether they associated with radionuclide contamination in vivo needs further study.…”

Plasma VEGF and Leptin Values in Patients With Gastric Intestinal Metaplasia and Metabolic Syndrome

“…It has been demonstrated that insulin may potentiate the mitogenic effect of EGF, which in turn activates pathways such as the Ras/mitogen-activated kinase, and promotes also the proliferation of the gastric mucosa cells ( 10 ). Other studies have reported strong association between obesity, SD2 and the development of IM, as well as of gastric cancer ( 11 – 13 ).…”