Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and META-analysis

Pizzol, Damiano; Smıth, Lee; Fontana, Luigi; Caruso, Maria Gabriella; Bertoldo, Alessandro; Demurtas, Jacopo; McDermott, Daragh T.; Garolla, Andrea; Grabovac, Igor; Veronese, Nicola

doi:10.1007/s11154-020-09541-0

Cited by 44 publications

(38 citation statements)

References 78 publications

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“…ED is associated with unmodifiable and modifiable common risk factors, including age, diabetes mellitus, dyslipidaemia, hypertension, CVD, BMI/obesity/waist circumference, MetS, hyperhomocysteinemia, lack of exercise, and smoking [73,74,76]. Furthermore, an association between ED status and pharmacotherapeutic agents for CVD (eg, thiazide diuretics and b-blockers, except nebivolol) exerts detrimental effects on erectile function, whereas other drugs (ie, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers) have neutral or even beneficial effects [3,71,77].…”

Section: Risk Factors For Edmentioning

confidence: 99%

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

et al. 2021

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Section: Risk Factors For Edmentioning

confidence: 99%

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

et al. 2021

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“…ED has a very complex aetiology which can involve numerous unmodifiable and modifiable factors, which are often present at the same time and usually can influence each other. Common risk factors include, besides DM, age, dyslipidaemia, hypertension, cardiovascular disease, obesity, metabolic syndrome (MetS), lack of exercise, and smoking 9‐11 . Vasculogenic factors are the most common and are both due to arterial inflow or venous outflow disorders 9 .…”

Section: The ‘Complicated Role’ Of Complications and Cofactors In The...mentioning

confidence: 99%

“…Common risk factors include, besides DM, age, dyslipidaemia, hypertension, cardiovascular disease, obesity, metabolic syndrome (MetS), lack of exercise, and smoking. 9 , 10 , 11 Vasculogenic factors are the most common and are both due to arterial inflow or venous outflow disorders. 9 Other factors include low testosterone levels, neurogenic and iatrogenic factors (related to a medical or surgical treatment).…”

Section: The ‘Complicated Role’ Of Complications and Cofactors In The...mentioning

confidence: 99%

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

Defeudis

Mazzilli

Tenuta

et al. 2021

Diabetes Metabolism Res

109

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Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common chronic diseases. The incidence and prevalence of DM have been increasing over the years. The complications of DM represent a serious health problem. The long-term complications include macroangiopathy, microangiopathy and neuropathy as well as sexual dysfunction (SD) in both men and women. Erectile dysfunction (ED) has been considered the most important SD in men with DM. The prevalence of ED is approximately 3.5-fold higher in men with DM than in those without DM. Common risk factors for the development of DM and its complications include sedentary lifestyle, overweight/ obesity and increased caloric consumption. Although lifestyle changes may help improve sexual function, specific treatments are often needed. This study aims to review the definition and prevalence of ED in DM, the impact of DM complications and DM treatment on ED and, finally, the current and emerging therapies for ED in patients with DM.

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“…This includes mental health, smoking, alcohol consumption, and BMI. 15 , 16 , 17 Unfortunately, our sample size is too small to correlate these variables with the primary results we have for the metoidioplasty population facing sexual challenges and their willingness to pursue remedial measures.…”

Section: Discussionmentioning

confidence: 99%

The Sexual Goals of Metoidioplasty Patients and Their Attitudes Toward Using PDE5 Inhibitors and Intracavernosal Injections as Erectile Aids

et al. 2022

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Background Following metoidioplasty, transmen (TM) experience sexual function challenges including erectile dysfunction, which is typically treated in cisgender men with phosphodiesterase-5 inhibitors (PDE5i) and intracavernosal injections (ICI). Aim We aim to evaluate sexual function post-metoidioplasty and explore attitudes toward using PDE5i and ICI as potential erectile aids Methods All patients who had metoidioplasty completed at the Gender Surgery Program in Vancouver, British Columbia were contacted. Participants completed an electronically accessible self-constructed questionnaire consisting of 39 items on erectile function, orgasm, and penetrative intercourse which also captured Erection Hardness Scores (EHS). Data were analyzed via t-test and 1-way ANOVA. Outcomes Our outcomes were the importance of erectile function, ability to orgasm, penetrative intercourse, and attitudes towards using PDE5i and ICI post-metoidioplasty. Results Fifteen out of 22 patients completed the survey (median age 32 years). Most had metoidioplasty within the past 2 years. The participants ranked the ability to orgasm and to achieve or maintain erections significantly higher than penetrative intercourse (P <.001, P =.005 respectively). Most participants reported facing challenges with penetrative intercourse (87%) and erectile function (80%). In contrast, a smaller proportion reported challenges with orgasm (33%). With regards to EHS, 83% of participants described their erections as either “larger but not hard,” or “hard but not hard enough for penetration.” A total of 47% of the participants had previously tried PDE5i, but none had used ICI. Although 87% were willing to use PDE5i, only 40% were willing to try ICI to improve their erections. Patients reported lack of knowledge and understanding among primary care physicians as barriers to accessing treatment for sexual dysfunction. Clinical Translation The results of this study can facilitate decision making for TM undergoing genital gender-affirmation surgery and provide potential options for improving erectile function post surgery. Strengths & Limitations This study represents the first assessment of sexual function and use of erectile aids in post-metoidioplasty patients. The results of this study are limited by the small sample size and enrolment from a single surgical center. Conclusion Metoidioplasty patients surveyed fail to achieve a fully rigid erection without treatment, typically retain the ability to orgasm, and are generally willing to try PDE5i.

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Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and META-analysis

Cited by 44 publications

References 78 publications

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

The Sexual Goals of Metoidioplasty Patients and Their Attitudes Toward Using PDE5 Inhibitors and Intracavernosal Injections as Erectile Aids

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