Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States)

Abstract

Components of energy balance are important elements associated with colorectal cancer risk. In this study we examine the association between VDR genotypes, BMI, physical activity, and energy intake and risk of colorectal cancer. Data from a population-based case-control study of colon (1174 cases and 1174 controls) and rectal (785 cases and 1000 controls) cancer was used to evaluate the associations. The Bsm1, polyA, and Fok1 VDR polymorphisms were evaluated. For colon cancer, those who are obese were at greater risk of colon cancer if they had the SS or BB (OR = 3.50; 95% CI = 1.75-7.03; p interaction 0.03) or ff (OR = 2.62; 95% CI = 1.15-5.99; p interaction 0.12/) VDR genotypes. On the other hand, those who were least physically active were at greater risk of colon cancer if they had the ff VDR genotype (OR = 3.46; 95% CI = 1.58-7.58; p interaction 0.05). The association between energy intake and colon cancer appears to be driven more by energy intake than Bsm1 or polyA VDR genotypes, although there was a significant interaction between the Fok1 VDR polymorphism and energy intake and risk of both colon and rectal cancer (p interaction 0.01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk.

Vitamin D Receptor BsmI Polymorphism and Colorectal Cancer Risk: an Updated Analysis

“…Controls were mainly healthy populations and matched for age and/or sex, of which five were population-based and nine were hospitalbased. There was a wide variation in the VDR BsmI B allele frequency among different ethnicities, ranging from 5.0% in an Asian population (Park et al, 2006) to 74.0% in another Asian population (Li et al, 2009) were in agreement with HWE except for four studies (Slattery et al, 2004;Theodoratou et al, 2008;Li et al, 2009;Gunduz et al, 2012). Table 2 listed the main results of this meta-analysis and Figure 1A-1D showed the association of CRC risk with VDR BsmI polymorphism.…”

“…Through screening the title and reading the abstract and the entire article, a total of fourteen eligible studies (Slatter et al, 2001;Speer et al, 2001;Slattery et al, 2004;Park et al, 2006;Flugge et al, 2007;Kadiyska et al, 2007;Slattery et al, 2007;Parisi et al, 2008;Theodoratou et al, 2008;Jenab et al, 2009;Li et al, 2009;Hughes et al, 2011;Mahmoudi et al, 2011;Gunduz et al, 2012) involving 10822 cases and 11779 controls were included in the pooled analyses finally. The characteristics of selected studies are summarized in Table 1.…”

Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European Populations

“…Considering cancer end points, studies on North American populations suggest that the BsmI BB or PolyA SS VDR genotypes may be associated with a reduced risk of cancer in the colon (19) and possibly in the rectum (20). In addition, the VDR Fok1 FF genotype has been associated with an increased risk of colon cancer in some North American (21) and South Asian populations (22). However, no data are currently available for any of these genotypes from European populations, and it is unclear to what extent any VDR-CRC risk association may be dependent on circulating vitamin D (25OHD) concentrations or level of dietary calcium intake.…”

Haplotype Analysis of Common Vitamin D Receptor Variants and Colon and Rectal Cancers

“…The potential associations between risk of colorectal cancers or adenomas and the VDR 3Vregion polymorphisms and/or the Fok1 polymorphism have been investigated in several studies (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The implications of the evidence from these studies are not completely clear, as some studies detected associations with the 3V region polymorphisms and others report associations with the Fok1 polymorphism.…”