Associations between B-cell non-Hodgkin lymphoma and exposure, persistence and immune response to hepatitis B

Kleinstern, Geffen; Seir, Rania Abu; Perlman, Riki; Abdeen, Ziad; Khatib, Areej; Elyan, Husein; Dann, Eldad J.; Kedmi, Meirav; Ellis, Martin; Nagler, Arnon; Amir, Gail; Yehuda, Dina Ben; Safadi, Rifaat; Paltiel, Ora

doi:10.3324/haematol.2016.144840

Cited by 12 publications

(11 citation statements)

References 12 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of previous case-control studies and meta-analyses have generally supported the presence of an association between HBV and the risk of NHL, especially of the large B cell lymphoma subtype. 26 , 27 , 32 Similarly, our data showed that anti-HBc status was associated with ENKTL status, implying that past or previous exposure to HBV was a risk factor for ENKTL diagnosis. However, the potential mechanisms underlying the association between HBV infection and NHL risk are unknown.…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

Association between extranodal natural killer/T-cell lymphoma and hepatitis B viral infection: a case-control study

Wang

Yang

et al. 2017

J. Cancer

View full text Add to dashboard Cite

Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare subtype of lymphoma that is often associated with poor clinical prognosis. Several studies have shown that hepatitis B virus (HBV) infection may be associated with increased risk of B-cell non-Hodgkin lymphoma; however, because of the rarity of ENKTL, little is known about its association with HBV. Our study aimed to assess whether HBV infection was associated with increased odds of ENKTL. We conducted a hospital-based case-control study including 417 ENKTL cases and 488 age- and sex-matched subjects with nonmalignant diseases unrelated to HBV infection. Multivariable unconditional logistic regression analyses were performed to estimate adjusted odds ratios [AOR] and their corresponding 95% confidence intervals (CI). The results of the multivariable analysis showed that after adjustment for a set of known risk factors, patients previously infected with HBV (HBsAg-seronegative/anti-HBc-seropositive) and naturally immune to HBV (anti-HBs-seropositive/anti-HBc-seropositive) were at significantly greater odds of being diagnosed with ENKTL (AOR, 1.497; 95% CI 1.098-2.042, P=0.033 and AOR, 1.871; 95% CI 1.302-2.689, P=0.001, respectively). After adjusting for other factors, significantly greater odds of being diagnosed with ENKTL were observed among cases who reported ever drinking alcohol (AOR, 1.675; 95% CI 1.054-2.660, P=0.029). The odds of ENKTL diagnosis were not significantly associated with ABO blood type, cigarette smoking status or family history of cancer. The results of our study suggest that patients previously infected with HBV and naturally immune to HBV were at greater odds of being diagnosed with ENKTL.

show abstract

Section: Discussionsupporting

confidence: 58%

“…Patients who were anti-HBs seropositive and anti-HBc seronegative were considered to have become HBV immune following vaccination. 32 …”

Section: Methodsmentioning

confidence: 99%

Association between extranodal natural killer/T-cell lymphoma and hepatitis B viral infection: a case-control study

Wang

Yang

et al. 2017

J. Cancer

View full text Add to dashboard Cite

show abstract

“…The literature search flow diagram is shown in Figure . According to the preset criteria for inclusion and exclusion, 9 cohort studies containing 1585 NHL incident cases among a total cohort size of 2 708 191 subjects and 49 case–control studies containing 52 129 NHL cases and 1 778 591 controls were finally enrolled in this analysis.…”

Section: Resultsmentioning

confidence: 99%

Hepatitis B virus and risk of non‐Hodgkin lymphoma: An updated meta‐analysis of 58 studies

Gan

Chen

et al. 2018

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Previous studies have focused on the relationship between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL). However, the results remain inconsistent and somehow conflicting in different subgroups. The aim of this study was to combine the findings of independent studies to comprehensively assess the association between HBV and NHL using a meta-analysis. Relevant studies were identified through structured keyword searches in PubMed, EMBASE and the China National Knowledge Infrastructure (CNKI) database, and 58 studies with a total of 53 714 NHL cases and 1 778 591 controls were finally included. Pooled estimates indicated a significantly increased NHL risk in HBV-infected individuals (summary odds ratio [sOR]: 2.50; 95% confidence interval [CI]: 2.20-2.83) regardless of the study design (case-control studies: sOR: 2.47; 95% CI: 2.16-2.82; cohort studies: sOR: 2.64; 95% CI: 1.78-3.91). Considerable heterogeneity was observed across studies that was primarily attributed to the NHL subtypes (meta-regression: P < .05). Overall, B-cell NHL (sOR: 2.46; 95% CI: 1.97-3.07) presented a stronger association with HBV infection than T-cell NHL (sOR: 1.67; 95% CI: 1.34-2.10). Within the B-cell NHL subtypes, HBV infection was significantly associated with diffuse large B-cell lymphoma (DLBCL, sOR: 2.06; 95% CI: 1.48-2.88) and follicular lymphoma (FL, sOR: 1.54; 95% CI: 1.11-2.12), but not with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) and Burkitt lymphoma. The results of this meta-analysis support a positive link between HBV infection and NHL development. Further investigations for the mechanisms underlying HBV-induced NHL are warranted.

show abstract

“…Whether this impact would parallel that of NHL has not been explored. A recent case‐controlled study explored the impact of the immune response to hepatitis B in developing NHL . However, it is from a nonendemic area and the case number is small; therefore, the impact of vaccination remains unclear.…”

Section: Discussionmentioning

confidence: 99%

The impact of hepatitis B virus infection and vaccination on the development of non‐Hodgkin lymphoma

Huang

Chen

Chang

et al. 2017

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection has been documented as a risk factor for non-Hodgkin lymphoma (NHL). However, there are few large cohort studies, and there is no report about the impact of HBV vaccination. We conducted this study to evaluate these issues. We used the nationwide cohort of the Taiwan National Health Insurance Research Database for 1997-2013. We compared the incidence and the risk of developing NHL and CD20 aggressive lymphoma between HBV and non-HBV cohorts. The hazard ratios (HRs) were computed using Cox proportional hazards models. We matched these two large cohorts to reconfirm the data. We also compared the incidence of NHL between cohorts born before and after the inception of universal HBV vaccination. We found that HBV infection increased the risk for developing NHL and CD20 aggressive lymphoma, with HRs of 4.14 and 5.52, with a higher incidence of 17.07 and 13.9 per 100 000 person-years, respectively, compared to the non-HBV cohort. The incidence of NHL in the cohort born in the era before universal HBV vaccination was higher with 1.85 per 100 000 person-years compared to 0.74 in the cohort born later aged younger than 20. Our study confirms that HBV confers a greater risk for developing NHL, especially CD20 aggressive lymphoma. The impact of HBV vaccination is protective against lymphoma development in the teenagers in an endemic area, but longer follow-up is needed for older age.

show abstract

Associations between B-cell non-Hodgkin lymphoma and exposure, persistence and immune response to hepatitis B

Cited by 12 publications

References 12 publications

Association between extranodal natural killer/T-cell lymphoma and hepatitis B viral infection: a case-control study

Association between extranodal natural killer/T-cell lymphoma and hepatitis B viral infection: a case-control study

Hepatitis B virus and risk of non‐Hodgkin lymphoma: An updated meta‐analysis of 58 studies

The impact of hepatitis B virus infection and vaccination on the development of non‐Hodgkin lymphoma

Contact Info

Product

Resources

About