Associations between anxiety disorders and physical illness

Härter, Martin; Conway, Kevin P.; Merikangas, Kathleen R.

doi:10.1007/s00406-003-0449-y

Cited by 256 publications

(160 citation statements)

References 18 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…A study in South Africa suggested that self-reported diagnosis of hypertension is more common among those with anxiety disorders, depressive disorders and comorbid anxiety-depression compared to those without a mental disorder [10]. Our findings about having controlled blood pressure is harder in the presence of psychological factors and mental disorders such as anxiety and depression were consistent with those of the several studies [11][12][13][14][15]. Rutledge and Hogan reported an overall increased hypertension risk among anxious subjects although the hypertension risk did not reach significance.…”

Section: Discussionsupporting

confidence: 82%

How do the Psychosocial Factors Affect Blood Pressure in Patients with Hypertension? A Cross-Sectional Study

Ersoy¹,

Saatçı²

2018

J Fam Med Dis Prev

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 82%

How do the Psychosocial Factors Affect Blood Pressure in Patients with Hypertension? A Cross-Sectional Study

Ersoy¹,

Saatçı²

2018

J Fam Med Dis Prev

View full text Add to dashboard Cite

show abstract

“…Furthermore, in contrast to controls, heart rate and systolic blood pressure increased significantly in boys with GAD after psychological stress testing (Gerra et al, 2000). Finally, patients with panic or GAD are 5.9 times more likely than controls to have cardiac disorders (angina, myocardial infarction, mitral valve prolapse), even after adjusting for comorbid depression, substance abuse, and gender (Härter, Conway, & Merikangas, 2003).…”

Section: Face Validitymentioning

confidence: 89%

Contextual conditioning in rats as an animal model for generalized anxiety disorder

Luyten

Vansteenwegen

Kuyck

et al. 2011

Cogn Affect Behav Neurosci

View full text Add to dashboard Cite

Animal models of psychiatric disorders are important translational tools for exploring new treatment options and gaining more insight into the disease. Thus far, there is no systematically validated animal model for generalized anxiety disorder (GAD), a severely impairing and difficult-to-treat disease. In this review, we propose contextual conditioning (CC) as an animal model for GAD. We argue that this model has sufficient face validity (there are several symptom similarities), predictive validity (it responds to clinically effective treatments), and construct validity (the underlying mechanisms are comparable). Although the refinement and validation of an animal model is a never-ending process, we want to give a concise overview of the currently available evidence. We suggest that the CC model might be a valuable preclinical tool to enhance the development of new treatment strategies and our understanding of GAD.

show abstract

“…Using criteria similar to ours, the Adverse Childhood Experiences (ACE) Study, a CDC supported prospective cohort study of 16,908 adults found a significant relationship between CPL and premature death in adulthood (Brown et al, 2009). Retrospective (e.g., Juang et al, 2004;Kopec and Sayre, 2005) and prospective longitudinal data (Fearon and Hotopf, 2001;Harter et al, 2003;Katerndahl 2008;Jones et al, 2009), link family disruption, physical abuse, separation and maternal loss in early life to chronic physical pain in adulthood. Whether the NL vs. SL probe has a differential effect on pain perception and physiological pain measures, and whether CPL status modifies this interaction should be explored.…”

Section: Panic and Comorbid Conditionsmentioning

confidence: 74%

Lifelong Opioidergic Vulnerability Through Early Life Separation: A Recent Extension of the False Suffocation Alarm Theory of Panic Disorder

Preter¹

2016

Panic Disorder

View full text Add to dashboard Cite

We briefly reference previous material on Klein's suffocation false alarm theory (SFA) of panic disorder (Klein, 1993) and its amplification in 2008 (Preter andKlein, 2008). We then discuss a recent finding showing a fundamental difference in opioidergic reactivity to a naloxone challenge in psychiatrically and medically healthy adults, based on the presence or absence of childhood separation/parental loss.In 1993, Klein published the original SFA theory of panic disorder (Klein, 1993), attempting to integrate the multiplicity of apparently unrelated clinical and laboratory observations. We posited "that a physiologic misinterpretation by a suffocation monitor misfires an evolved suffocation alarm system. This produces sudden respiratory distress followed swiftly by a brief hyperventilation, panic, and the urge to flee. Carbon dioxide hypersensitivity is seen as due to the deranged suffocation alarm monitor. If other indicators of potential suffocation provoke panic, this theoretical extension is supported." In the original paper, we tested "the theory by examining Ondine's curse as the physiologic and pharmacologic converse of panic disorder, splitting panic in terms of symptomatology and challenge studies, reevaluating the role of hyperventilation, and reinterpreting the contagiousness of sighing and yawning, as well as mass hysteria." (Klein, 1993) Original SFA focused on relating the observed lactate and carbon dioxide hypersensitivity in panic disorder to a putative dysfunction in a hypothesized suffocation alarm. At the time, the underlying pathophysiology that might connect the apparent disparate "phenomena of panic during relaxation and sleep, late luteal phase dysphoric disorder, pregnancy, childbirth, pulmonary disease, separation anxiety, and treatment", was unknown.

show abstract

Associations between anxiety disorders and physical illness

Abstract: Anxiety disorders were associated with a specific pattern of cardiac disorders, hypertension, gastrointestinal problems, genitourinary difficulties, and migraine; individuals presenting with anxiety disorders or medical illness need therefore to be evaluated carefully for comorbidity.

Cited by 256 publications

References 18 publications

How do the Psychosocial Factors Affect Blood Pressure in Patients with Hypertension? A Cross-Sectional Study

How do the Psychosocial Factors Affect Blood Pressure in Patients with Hypertension? A Cross-Sectional Study

Contextual conditioning in rats as an animal model for generalized anxiety disorder

Lifelong Opioidergic Vulnerability Through Early Life Separation: A Recent Extension of the False Suffocation Alarm Theory of Panic Disorder

Contact Info

Product

Resources

About