Associations Between Anxiety, Depression, and the Metabolic Syndrome

Skilton, Michael R.; Moulin, Philippe; Terra, Jean‐Louis; Bonnet, Fabrice

doi:10.1016/j.biopsych.2007.01.012

Cited by 266 publications

(237 citation statements)

References 33 publications

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“…Diaz-Martinez et al (2007) found no significant association between MS and depressive symptoms, as well as Herva et al (2006), who also found no clear association between depressive symptoms with MS or between MS and anxiety symptoms. These findings are different to those of other authors who found an association between depressive symptoms and MS, regardless of age, sociodemographic and lifestyle, but did not observe the same association with anxiety symptoms (Skilton et al, 2007).…”

Section: Discussioncontrasting

confidence: 99%

“…Moreover, anxiety symptoms tend to increase the risk of the onset of depression (Van Praag, 2005). However, few studies have measured the intensity of anxious and depressive symptoms simultaneously, correlating the scores (Skilton, Moulin & Terra, 2007). The present study aimed to determine the intensity of symptoms of depression and anxiety in patients with MS and correlate it to socio-demographic variables.…”

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confidence: 94%

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Depressive and anxiety symptoms in patients with Metabolic Syndrome

Sharovsky

Romano

2013

Estud. psicol. (Campinas)

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Depressive symptoms have been associated to the Metabolic Syndrome. Nevertheless, only a few studies have evaluated anxiety and depression concomitantly. The objective of the research was to evaluate the intensity of depressive and anxiety symptoms in patients with Metabolic Syndrome and their relation to demographic variables. A unicenter, transversal study was carried out. A social demographic questionnaire was used. Depressive symptoms were measured with Beck Depression Inventory and anxiety symptoms were measured with Hamilton Anxiety Scale Rate. A total of 103 ambulatory patients, 60 of them men, with mean age 55.4 years (±7,6) with a diagnosis of Metabolic Syndrome were included in the study. Anxiety symptoms of very severe intensity were present in 51.5% (n=53) while severe depressive symptoms in only 5.8% (n=6). Anxiety and depressive symptoms were significantly associated. In this sample, anxiety predominated in relation to the depressive symptoms. The anxiety symptoms were more intense in women and that had low level of education.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 94%

Depressive and anxiety symptoms in patients with Metabolic Syndrome

Sharovsky

Romano

2013

Estud. psicol. (Campinas)

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“…6,7 Epidemiological and clinical studies strongly suggest comorbidity between MD and MetS. [10][11][12] On the one hand, MD patients harbor an elevated risk for insulin resistance, 13 obesity 14 and, consequently MetS, 10 on the other hand, patients suffering from MetS are at a higher risk for depressive disorders. 11,12,15 Beyond environmental factors such as sedentary lifestyle, 16 genetic susceptibility is important in the development of MetS.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] On the one hand, MD patients harbor an elevated risk for insulin resistance, 13 obesity 14 and, consequently MetS, 10 on the other hand, patients suffering from MetS are at a higher risk for depressive disorders. 11,12,15 Beyond environmental factors such as sedentary lifestyle, 16 genetic susceptibility is important in the development of MetS. 17,18 Several genetic associations with MetS or its components have been reported with most studies focusing on insulin signaling, glucose homeostasis, lipoprotein metabolism pathways and genes involved in adipogenesis, inflammation processes, vascular function and coagulation.…”

Section: Introductionmentioning

confidence: 99%

Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression

et al. 2009

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Major depression and the metabolic syndrome (MetS) are interacting clinical conditions influenced by genetic susceptibility. For both disorders, impaired serotonergic neurotransmission in specific brain areas has been suggested. This led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (TPH2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be predictive for an increased liability for the development of MetS in depressed patients. In a case-control study consisting of 988 patients with recurrent unipolar depression (RUD) and 1023 psychiatric healthy controls, MetS components were ascertained according to the International Diabetes Foundation criteria. A total of 41 single nucleotide polymorphisms fully covering the TPH2 gene region were genotyped in stage 1 (300 patients/300 controls), resulting in significant genetic associations of polymorphisms located in exon 7 and intron 8 of TPH2 and the occurrence of MetS in depressed patients after correction for age, gender and multiple testing (51 RUD-MetS/179 RUD-non-MetS). We were able to confirm the significant association of rs17110690 in stage 2 (688 patients/723 controls; 110 RUD-MetS/549 RUD-non-MetS) and to link risk-genotypes and risk-haplotypes for MetS to lower TPH2 mRNA expression and to lower 5-hydroxyindoleacetic acid levels in cerebrospinal fluid previously reported in functional studies. Our findings suggest that TPH2 polymorphisms characterize a subgroup of depressed patients who are especially prone to develop metabolic disorders induced by a genotype-dependent impairment of serotonergic neurotransmission. Identifying depressed patients at high risk for MetS using genetic variants could have direct clinical impact on individualized disease management and prevention strategies.

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“…Several studies have found a social gradient in both work stress and metabolic syndrome (41)(42)(43), suggesting that the social gradient in metabolic syndrome and heart disease may be partly explainable by greater exposure to work stress Table 1 Means, standard deviations, Cronbach's Alpha and interscale correlations (n = 79) among less advantaged social groups. Metabolic syndrome and obesity have also been linked to several other psychological factors: body dissatisfaction, self-esteem, depression (44)(45)(46), stress (47)(48)(49), and positive and negative affect (50)(51). In line with previous reports, our study revealed that, in comparison with controls, overweight participants had significantly higher values of depression (6.75 ± 2.87 vs. 4.93 ± 3.32, P < 0.05) and anxiety (7.33 ± 2.68 vs. 6.03 ± 2.92, P < 0.05), and lower levels of optimism (15.13 ± 3.69 vs. 17.85 ± 3.95, P < 0.01) and satisfaction with life (21.49 ± 5.77 vs. 24.70 ± 6.80, P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Involvement of psychosocial factors in the association of obesity with periodontitis

Dumitrescu

Kawamura

2010

J Oral Sci

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The present case-control study of 79 subjects (19-69 yr) was designed to assess the relationship of several psychological determinants to periodontal disease and obesity. Periodontal clinical examinations were performed, and the subjects were asked to complete a set of questionnaires measuring Type A personality, anxiety, depression, dental anxiety, hopelessness, emotional intelligence, stress, self-esteem, optimism and satisfaction with life. In a bivariate analysis, overweight individuals presented higher levels of smoking exposure, anxiety and depression and lower levels of optimism and satisfaction with life. They were mainly females, with a higher number of sites and teeth with probing depth (PD) >6 mm and clinical attachment level (CAL) >5 mm. Patients with a mean PD exceeding 3 mm and a bleeding on probing index of >25% presented higher values of dental anxiety and lower levels of self-esteem. Multiple linear regression analyses revealed that dental anxiety was positively associated with the number of teeth with a PD of >6 mm and with reasons for visiting a dentist, while satisfaction with life was associated with flossing frequency. We conclude that there is an association between several psychological determinants, periodontitis, and body mass index. (J Oral Sci 52, 115-124, 2010)

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Associations Between Anxiety, Depression, and the Metabolic Syndrome

Cited by 266 publications

References 33 publications

Depressive and anxiety symptoms in patients with Metabolic Syndrome

Depressive and anxiety symptoms in patients with Metabolic Syndrome

Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression

Involvement of psychosocial factors in the association of obesity with periodontitis

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