Associations Between Antral Ovarian Follicle Dynamics and Hormone Production Throughout the Menstrual Cycle as Women Age

Brink, Heidi Vanden; Robertson, David; Lim, Hyun J.; Lee, Chel Hee; Chizen, Donna R.; Harris, Guy M.; Hale, Georgina E.; Burger, Henry G.; Baerwald, Angela

doi:10.1210/jc.2015-2643

Cited by 24 publications

(30 citation statements)

References 24 publications

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“…Additionally, AMH level exhibits increasing intracycle variation as women approach menopause; AMH level may have been detectable in this group of still‐cycling women if measured at a different time point during a cycle when antral follicle count was higher (Robertson et al, ). AMH level has been shown to be more tightly correlated with antral follicle count in younger women, but the relationship is less consistent in late reproductive age, which might account for continued reports of menstrual bleeding in the absence of a detectable AMH level (Robertson et al, ; Vanden Brink et al, ).…”

Section: Discussionmentioning

confidence: 99%

Variation in levels of AMH among Maya and non‐Maya women in Campeche, Mexico

Kyweluk

Sievert

Gómez

et al. 2018

American J Phys Anthropol

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Increasing age and progression through the menopausal transition were both associated with declining levels of AMH. The association between Maya ethnicity and a lower likelihood of detecting AMH is consistent with the early ages at menopause reported in previous studies. We considered a rapid life history model as an explanatory framework, and suggest, from an ecological perspective, that future research should consider measures of developmental stress that may compromise ovarian reserves.

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Section: Discussionmentioning

confidence: 99%

Variation in levels of AMH among Maya and non‐Maya women in Campeche, Mexico

Kyweluk

Sievert

Gómez

et al. 2018

American J Phys Anthropol

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“…Prior studies included younger women. There are data that suggest that luteal phase length may decrease with age (21, 22). …”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of luteal phase length and natural fertility

Crawford

Pritchard

Herring

et al. 2017

Fertility and Sterility

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Objective To evaluate the impact of a short luteal phase on fecundability. Design Prospective, time to pregnancy cohort study Setting Community-based cohort Patient(s) Women trying to conceive, ages 30–44 years, without known infertility Intervention(s) Daily diaries, ovulation prediction testing, standardized pregnancy testing Main Outcome Measure(s) Subsequent cycle fecundability Result(s) 1,635 cycles from 284 women were included in the analysis. A short luteal phase (length of 11 days or less including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy (95% CI: 0.46–1.47) in the subsequent cycle immediately following the short luteal phase when compared to women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months, there was no significant difference in cumulative probability of pregnancy. Conclusion(s) Although an isolated cycle with a short luteal phase may negatively impact short-term fertility, incidence of infertility at 12 months was not significantly higher among these women.

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“…Changes in gonadotropin secretion throughout menopausal transition and after menopause, characterised by increased luteinising hormone (LH) and FSH pulse amplitude and loss of pre-ovulatory gonadotropin surges, are caused by altered feedback resulting from the intrinsically determined ovarian decline in sex steroids, inhibin A, and inhibin B production. 57,58,60 The existence of direct age-related neuroendocrine changes, as revealed by the progressive decline of gonadotropin concentrations with advancing age after menopause, appears to be less physiologically relevant than the intrinsic ovarian changes. 56,61 Throughout reproductive life and menopausal transition, there is an age-related decreasing trend of adrenal production of DHEA and DHEAS, and of mixed adrenal and ovarian production of testosterone and androstenedione.…”

Section: Hypothalamic–pituitary–peripheral Organ Axesmentioning

confidence: 99%

The physiology of endocrine systems with ageing

Beld

Kaufman

Zillikens

et al. 2018

The Lancet Diabetes & Endocrinology

231

121

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During ageing, the secretory patterns of the hormones produced by the hypothalamic–pituitary axis change, as does the sensitivity of the axis to negative feedback by end hormones. Additionally, glucose homoeostasis tends towards disequilibrium with increasing age. Along with these endocrine alterations, a loss of bone and muscle mass and strength occurs, coupled with an increase in fat mass. In addition, ageing-induced effects are difficult to disentangle from the influence of other factors that are common in older people, such as chronic diseases, inflammation, and low nutritional status, all of which can also affect endocrine systems. Traditionally, the decrease in hormone activity during the ageing process has been considered to be detrimental because of the related decline in bodily functions. The concept of hormone replacement therapy was suggested as a therapeutic intervention to stop or reverse this decline. However, clearly some of these changes are a beneficial adaptation to ageing, whereas hormonal intervention often causes important adverse effects. In this paper, we discuss the effects of age on the different hypothalamic–pituitary–hormonal organ axes, as well as age-related changes in calcium and bone metabolism and glucose homoeostasis.

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Associations Between Antral Ovarian Follicle Dynamics and Hormone Production Throughout the Menstrual Cycle as Women Age

Cited by 24 publications

References 24 publications

Variation in levels of AMH among Maya and non‐Maya women in Campeche, Mexico

Variation in levels of AMH among Maya and non‐Maya women in Campeche, Mexico

Prospective evaluation of luteal phase length and natural fertility

The physiology of endocrine systems with ageing

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