Associations between Alzheimer’s Disease and Blood Homocysteine, Vitamin B&lt;sub&gt;12&lt;/sub&gt;, and Folate: A Case-Control Study

Chen, Hui; Liu, Shuai; Ji, Lü; Wu, Tianfeng; Ma, Fei; Ji, Yong; Zhou, Yuying; Zheng, Miaoyan; Zhang, Meilin; Huang, Guowei

doi:10.2174/1567205012666141218144035

Cited by 51 publications

(39 citation statements)

References 34 publications

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“… 53 Vitamin B 12 deficiency is associated with cognitive impairment, and the level of circulating vitamin B 12 has been associated with AD risk. 54 ABCD4 encodes an adenosine triphosphate–binding cassette transporter that is in the same family as well-established AD gene ABCA7 . 39 , 40 The AD-associated CELSR1 rs61741871 (P2983A) missense variant has also been associated with craniorachischisis, which is a severe neural tube defect, 55 and other CELSR1 variants have been identified as ischemic stroke risk factors in Japanese individuals.…”

Section: Discussionmentioning

confidence: 99%

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

et al. 2019

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Key Points Question Can rare genetic variants for Alzheimer disease be identified using nonstatistical approaches? Findings In this genetic association study, variants with high functional effect were observed in participants with Alzheimer disease but not in controls in NOTCH3 , a gene previously associated with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and TREM2 (Q33X) that in homozygous form causes Nasu-Hakola disease. Meaning Different mutations in the same gene or variable dose of a particular mutation may be associated with dissimilar types of dementia.

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Section: Discussionmentioning

confidence: 99%

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

et al. 2019

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“…Fifth, the confounding influence of homocysteine was only adjusted for in a few of the included studies [19,28]. Excessive homocysteine increases the risk of endothelial dysfunction and increases the cardiovascular risk, which directly contributes to the development of dementia and AD by promoting neurodegenerative changes [45]. Therefore, failure to adjust for this confounding factor may result in biased conclusions.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

et al. 2019

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Background: We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). Methods: We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. Results: Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml). Conclusion: There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml).

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“…High serum Hcy content, caused by deficiency of B vitamins has been reported to be associated with the risk of AD in population based studies [25,26,27,28]. Gorgone and coworkers found that hyperhomocysteinemia damaged cognitive function via micro-vascular damage and direct neuro-toxic effect [29].…”

Section: Discussionmentioning

confidence: 99%

Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status with Cognitive Functions in Chinese Adults

et al. 2016

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Background/Aim: Studies have indicated a relationship between either gene polymorphism or in vivo B vitamins’ nutritional status with cognition in the elderly. However, the combined effects of MTHFR and SLC19A1gene polymorphism with serum folate and vitamin B12 levels on cognition in Chinese adult population remain unclear. Methods: Demographic information of 426 Chinese adults aged from 55 to 90 were collected by a well designed self-administered questionnaire. The Montreal Cognitive Assessment test was utilized to evaluate the cognition status of the participants. MTHFR and SLC19A1 genotyping was analyzed using polymerase chain reaction-ligase detection reaction (PCR- LDR) method. Serum folate, vitamin B12 and homocysteine (Hcy) levels were detected by commercial assay kits. Pearson’s correlation was used for data analyses and statistical significance was set at p < 0.05. Results: Serum Hcylevels demonstrated a negative correlation with serum folate (r = −0.301) and vitamin B12 (r = −0.292) levels. The negative correlation found between serum Hcy levels and attention ability was observed in all 426 studied subjects (r = −0.122). Subjects with MTHFR 677 T/T and 1298 A/A genotypes demonstrated a higher serum Hcy levels (p < 0.05). Carriers of MTHFR (1298 A/C + C/C and 1793 G/A) and SLC19A1 80 G/G genotypes showed lower abstraction and delayed memory ability, respectively (p < 0.05). Subjects with MTHFR 1793 G/A genotype along with low serum folate concentration demonstrated the lowest name and orientation abilities. The effects of MTHFR 1793 G/A genotype on cognitive performance were dependent on the status of serum vitamin B12. Conclusion: Cognition of adults was associated with MTHFR, SLC19A1 gene polymorphism and serum Hcy levels. This study clearly establishes a combined effect of MTHFR gene polymorphism and serum B vitamins levels on cognition in Chinese adults.

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Associations between Alzheimer’s Disease and Blood Homocysteine, Vitamin B<sub>12</sub>, and Folate: A Case-Control Study

Abstract: Vitamin B12 was directly associated with AD. The combination of high Hcy, low vitamin B12, and any folate level represented the poorest association with AD.

Cited by 51 publications

References 34 publications

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B12 and Hcy Status with Cognitive Functions in Chinese Adults

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