Associations between alcohol use disorder polygenic score and remission in participants from high‐risk families and the Indiana Biobank
Dongbing Lai,
Sally I‐Chun Kuo,
Leah Wetherill
et al.
Abstract:BackgroundIn the United States, ~50% of individuals who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score for AUD (PGSAUD) was positively associated with AUD severity as measured by DSM‐5 lifetime criterion count, and AUD severity was negatively associated with remission. Thus, we hypothesized that PGSAUD would be negatively associated with remission.MethodsIndividuals of European (EA) and African ancestry (AA) from the Collaborative… Show more
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