Associations between Age-Related Changes in the Core Vestibular Projection Pathway and Balance Ability: A Diffusion Tensor Imaging Study

Abstract

Objective. We investigated the changes of the vestibulospinal tract (VST) and parietoinsular vestibular cortex (PIVC) using diffusion tensor imaging (DTI) and relation to balance between old and young healthy adults. Methods. This study recruited eleven old adults (6 males, 5 females; mean age 63.36±4.25 years) and 12 young adults (7 males, 5 females; mean age 28.42±4.40 years). The lateral and medial VST and PIVC were reconstructed using DTI. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume were measured. The six-minute walk test (6-MWT), the timed up and go test (TUG), and the Berg balance scale (BBS) were conducted. Spatiotemporal parameters during tandem gait and values of sway during one-leg standing using the wearable sensors were measured. All parameters between two groups were analyzed by the Mann-Whitney U test and independent t-test. Results. Statistically significant decrease in old adults was detected in the tract volume of lateral (p=0.005) and medial VST (p≤0.001) and PIVC (p=0.020). A significant decrease in FA of lateral VST (p=0.044) and MD of medial VST (p=0.001) was seen in old adults. Stride length (p=0.003) and velocity (p=0.001) during tandem gait in old adults were significantly decreased. 6MWT (p≤0.001) showed significant decrease, while TUG (p≤0.001) showed significant increase in old adults. However, mean BSS (p=0.296) was nonsignificantly different. In eyes-open condition during one-leg standing, all parameters except for reciprocal compensatory index (RCI) values were significantly decreased in old adults. The RCI in the anteroposterior (AP) direction (p≤0.001) was increased in old adults; however, the mediolateral direction (p=0.301) was nonsignificantly different between the two groups. In eye-closed condition, the changes of ankle (p=0.031) and hip (p=0.004) sway and the center of mass in the AP direction (p=0.014) showed to be significantly higher in old adults than in young adults. Conclusion. The results suggested that there was a relationship between DTI parameters in the vestibular neural pathway and balance according to aging.

Diagnostic usefulness of 10-step tandem gait test for the patient with degenerative cervical myelopathy

“…Tandem gait is considered a useful marker of dysfunction in neurologic conditions 19 – 21 . Since the early nineteenth century, tandem gait testing has been used for the neurological examination of lower extremity dysfunction in patients with cerebellar disease, parkinsonism, vestibulopathies, and other conditions.…”

Relationship between Dizziness and the Core Vestibular Projection Injury in Patients with Mild Traumatic Brain Injury

“…Because both the VN and the PIVC are associated with dizziness, the above studies suggested that the CVP injury was associated with dizziness and coincided with the present results. Meanwhile, Yeo et al (2020) reported that the TV of the CVP was associated with age [48]. Thus, we recruited the patients who were younger than 50 years old in this study.…”

Associations Between Injury of the Parieto-Insular Vestibular Cortex and Changes in Motor Function According to the Recovery Process: Use of Diffusion Tensor Imaging

“…In DTI studies, Yeo et al ( 34 ) demonstrated patients with injury of the vestibulospinal tract following lateral medullary syndrome (e.g., loss of consciousness, ataxia, postural instability, confusion, headache, incoordination, and visual deficits) ( 4 ). In 2019, Yeo et al showed the relationship between the vestibular neural pathway, including the projection pathway to the PIVC and the vestibulospinal tract and balance according to aging.…”

“…In 2019, Yeo et al showed the relationship between the vestibular neural pathway, including the projection pathway to the PIVC and the vestibulospinal tract and balance according to aging. Moreover, DTI parameters in the vestibular neural pathway are associated with age-related reductions in balance ability ( 34 ). Together, these results commonly show that the PIVC is associated with central vestibular disorders and impairment of body movement, especially balance and gait function because PIVC encodes the vestibular signals contributing to self-motion perception ( 33 ).…”