Associations Between Age at Menarche and Menopause With Cardiovascular Disease, Diabetes, and Osteoporosis in Chinese Women

Qiu, Changsheng; Chen, Hongjie; Wen, Junping; Zhu, Pengli; Lin, Fen; Huang, Baoying; Peijian, Wu; Lin, Qian; Lin, Yuan; Rao, Huiying; Huang, Huibin; Liang, Jing; Li, Liantao; Gong, Xueying; Peng, Shushan; Li, Meizhi; Chen, Ling; Tang, Kaka; Chen, Zichun; Li, Lin; Lu, Jieli; Bi, Yufang; Ning, Guang; Chen, Gang

doi:10.1210/jc.2012-2919

Cited by 143 publications

(142 citation statements)

References 45 publications

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“…Menarche and menopause out of the common range have been associated with risk for various diseases, including breast cancer (Velie et al 2005;Vogel 2008), endometrial and ovarian cancer (Hinds and Price 2010;Cramer 2012), cardiovascular disease (Cui et al 2006), and osteoporosis (Qiu et al 2013;Parker et al 2014). It has been well recognized that genetic makeup influences both AM (Sharma 2002;Anderson et al 2008) and ANM (de Bruin et al 2001;Murabito et al 2005;Morris et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Age at menarche and age at natural menopause in East Asian women: a genome-wide association study

Shi

Zhang

Choi

et al. 2016

AGE

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Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high heritability. Abnormal timing of menarche or menopause is associated with a reduced span of fertility and risk for several age-related diseases including breast, endometrial and ovarian cancer, cardiovascular disease, and osteoporosis. To identify novel genetic loci for AM or ANM in East Asian women and to replicate previously identified loci primarily in women of European ancestry by genome-wide association studies (GWASs), we conducted a two-stage GWAS. Stage I aimed to discover promising novel AM and ANM loci using GWAS data of 8073 women from Shanghai, China. The Stage II replication study used the data from another Chinese GWAS (n = 1230 for AM and n = 1458 for ANM), a Korean GWAS (n = 4215 for AM and n = 1739 for ANM), and de novo genotyping of 2877 additional Chinese women. Previous GWAS-identified loci for AM and ANM were also AGE (2016) ) and rs1023935 at 4p15.1 (beta = −0.145 years, P = 4.9 × 10 −6) and one menopausal age locus tagged by rs3818134 at 22q12.2 (beta = −0.276 years, P = 8.8 × 10 −6). These suggestive loci warrant a further validation in independent populations. Although limited by low statistical power, we replicated 19 of the 98 menarche loci and 5 of the 20 menopause loci previously identified in women of European ancestry in East Asian women, suggesting a shared genetic architecture for these two traits across populations.

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Section: Introductionmentioning

confidence: 99%

Age at menarche and age at natural menopause in East Asian women: a genome-wide association study

Shi

Zhang

Choi

et al. 2016

AGE

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“…Consequently, hormone therapy use may confound the relationship between age at menopause and CVD risk. Indeed, HRT was only adjusted for in a minority of identified studies [27][28][29][30][31] . Moreover, since the number of available studies in some of our analysis was small, it precluded our ability to comprehensively assess the impact of type of menopause in our results.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

et al. 2016

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Role of the Funder/Sponsor: Metagenics Inc. had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscript.The funder/sponsor did not have the ability to veto publication of study results. Data Extraction: Data were extracted by two independent reviewers using a pre-designed data collection form. Word count text: 3494 wordsMain outcomes and Measures: CVD outcomes (composite CVD, fatal and non-fatal coronary heart disease (CHD) and overall stroke and stroke mortality), CVD-mortality, all-cause mortality and intermediate CVD endpoints.Results: Out of initially identified references, 32 studies were selected, including 310,329 non-overlapping women. Women with a menopausal age of younger than 45 years compared to women with a menopausal age of 45 years or older, the relative risk (RR) [95% confidence intervals (CI)] was 1.50(1.28-1.76) for overall CHD, 1.11(1.03-1.20) for fatal CHD, 1.23 (0.98-1.53) for overall stroke, 0.99 (0.92-1.07) for stroke mortality, 1.19(1.08-1.31) for CVD mortality and 1.12(1.03-1.21) for all-cause mortality. For women with a menopausal age between 50-54 years compared to women with a menopausal age of younger than 50 years, there was a decreased risk of fatal CHD (RR:0.87(95%CI:0.80-0.96)), and no effect on stroke. Duration since menopause in relation to risk of developing intermediate cardiovascular traits or CVD outcomes was reported in 4 observational studies, reporting no consistent results. Conclusions and Relevance:The findings of this review indicate an excess CHD, CVD-mortality and overall mortality risk in women who have an early or premature menopause.

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“…The age at menopause onset is a risk factor for long-term morbidity and mortality, late menopause being a risk factor for endometrial and breast cancer, and early menopause being a risk factor for osteoporosis and cardiovascular diseases; a risk that occurs because of estrogen deficiency [10]. In Chinese women with postmenopausal osteoporosis, the onset of menopause before 46 years old is associated with an increased risk of osteoporosis [11]. Although the estrogen hormonal decline is the main driver of bone metabolism imbalance in osteoporosis, it explains only a small proportion of the interindividual variations of bone mineral density (BMD) and bone loss [12].…”

Section: Resultsmentioning

confidence: 99%

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

Török-Oance

Bala

2015

Asian Biomedicine

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Background: Osteoporosis is a metabolic bone disease with a risk factor of being female, particularly after the onset of menopause. Objectives: To evaluate the influence of age, anthropometric, and reproductive variables on spinal bone mineral density (BMD) in women with postmenopausal vertebral osteoporosis. Methods: The study was retrospective and included data from 171 patients with postmenopausal vertebral osteoporosis. We performed both simple and multiple regressions considering BMD in spine as the dependent variable. Coefficients of correlation (r), coefficients of determination (r

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Associations Between Age at Menarche and Menopause With Cardiovascular Disease, Diabetes, and Osteoporosis in Chinese Women

Cited by 143 publications

References 45 publications

Age at menarche and age at natural menopause in East Asian women: a genome-wide association study

Age at menarche and age at natural menopause in East Asian women: a genome-wide association study

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

Body weight, BMI, and stature have a protective effect on bone mineral density in women with postmenopausal vertebral osteoporosis, whereas greater age at menarche and years after menopause have a negative effect

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