Associations Between Adverse Childhood Experiences, Psychological Distress, and Adult Alcohol Problems

Strine, Tara W.; Dube, Shanta R.; Edwards, Valerie J.; Prehn, Angela W.; Rasmussen, Sandra; Wagenfeld, Morton O.; Dhingra, Satvinder; Croft, Janet B.

doi:10.5993/ajhb.36.3.11

Cited by 180 publications

(123 citation statements)

References 47 publications

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“…Several correlational Level III studies, found a significant relationship of ACE on alcohol and mental health disorders (Choi, Dinitto, Marti, & Choi, 2017), adult mental health within a health maintenance organization (Edwards et al, 2003), negative affect as a predictor of impact of ACE on mental health (Lanoue, Graeber, Helitzer, & Fawcett, 2013), relationship between ACE and psychological distress, alcohol use (Strine et al, 2012); and ACE and adult substance abuse (Banducci et al, 2014;Mandavia et al, 2016;Mersky, Topitzes, & Reynolds, 2013). A Level II systematic review of health consequences of ACE provided evidence for the necessity of screening for ACE in the primary care setting (Kalmakis & Chandler, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…Knowledge concerning the prolonged effects of ACE on the physical, emotional, and psychological long-term functioning is lacking. Education on the underlying pathology contributing to physical and mental illness throughout the lifespan in individuals with a history of ACE is needed within the SUD treatment community (Blakey & Bowers, 2014;Cohen et al, 2013;Grupp, 2008;Mandavia, Robinson, Bradley, Ressler, & Powers, 2016;Strine et al, 2012). Although women are particularly vulnerable, implementation of a trauma-informed care (TIC) model is essential for all individuals with a history of ACE,…”

Section: Screening and Brief Intervention For Adverse Childhood Expermentioning

confidence: 99%

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Screening Adults With Substance Use Disorder for Adverse Childhood Experiences

Chandler

Kalmakis²,

Murtha³

2018

UJAN

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Objective: The purpose of this study was to assess the incidence of adverse childhood experiences (ACEs) and the efficacy and feasibility of a trauma-informed screening for ACEs among individuals in a substance use disorder recovery program. Method: Individual interviews, questionnaires, and postinterview survey and reflections were used in this cross-sectional clinical translation project. Descriptive statistics were used to analyze demographics, ACE scores, protective childhood experiences, self-reported diagnoses, and postintervention survey data. Postinterview reflections were reviewed and grouped into common ideas as shared by participants, as well as interesting impressions, insights, and responses to the interviews. Results: Thirty clients participated in the interview process. Among the 29 participants who completed the questionnaires, all reported at least one ACE, and 82.8% reported six or more ACEs. In addition, 96.6% reported experiencing more than four protective factors. Twelve (40%) clients were referred for further mental health counseling after the interviews. Notable findings from the interviews were the general lack of awareness of the relationship between ACEs and current substance use disorder among participants. Gaining knowledge about the impact of ACEs on their recovery seemed to provide a sense of relief and a feeling that they were “normal.” Conclusions: The trauma-informed care approach is intended to promote mindfulness regarding the effect of ACEs on substance abuse in this population. Screening for ACEs is necessary if effective interventions are to be provided, with the goal of improving client outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Screening and Brief Intervention For Adverse Childhood Expermentioning

confidence: 99%

Screening Adults With Substance Use Disorder for Adverse Childhood Experiences

Chandler

Kalmakis²,

Murtha³

2018

UJAN

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“…Chronic early-life stress, such as childhood neglect, often results in anxiety and affective disorders and increased probability of drug and alcohol abuse in adulthood (Anda et al, 2002;Strine et al, 2012;Gershon et al, 2013). Despite the deleterious health consequences associated with early-life stress, relatively little is known about the specific neurobiological adaptations that contribute to these conditions.…”

Section: Introductionmentioning

confidence: 99%

Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System

Karkhanis¹,

Rose

Weiner³

et al. 2016

Neuropsychopharmacol

106

107

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Chronic early-life stress increases vulnerability to alcoholism and anxiety disorders during adulthood. Similarly, rats reared in social isolation (SI) during adolescence exhibit augmented ethanol intake and anxiety-like behaviors compared with group housed (GH) rats. Prior studies suggest that disruption of dopamine (DA) signaling contributes to SI-associated behaviors, although the mechanisms underlying these alterations are not fully understood. Kappa opioid receptors (KORs) have an important role in regulating mesolimbic DA signaling, and other kinds of stressors have been shown to augment KOR function. Therefore, we tested the hypothesis that SI-induced increases in KOR function contribute to the dysregulation of NAc DA and the escalation in ethanol intake associated with SI. Our ex vivo voltammetry experiments showed that the inhibitory effects of the kappa agonist U50,488 on DA release were significantly enhanced in the NAc core and shell of SI rats. Dynorphin levels in NAc tissue were observed to be lower in SI rats. Microdialysis in freely moving rats revealed that SI was also associated with reduced baseline DA levels, and pretreatment with the KOR antagonist nor-binaltorphimine (nor-BNI) increased DA levels selectively in SI subjects. Acute ethanol elevated DA in SI and GH rats and nor-BNI pretreatment augmented this effect in SI subjects, while having no effect on ethanol-stimulated DA release in GH rats. Together, these data suggest that KORs may have increased responsiveness following SI, which could lead to hypodopaminergia and contribute to an increased drive to consume ethanol. Indeed, SI rats exhibited greater ethanol intake and preference and KOR blockade selectively attenuated ethanol intake in SI rats. Collectively, the findings that nor-BNI reversed SI-mediated hypodopaminergic state and escalated ethanol intake suggest that KOR antagonists may represent a promising therapeutic strategy for the treatment of alcohol use disorders, particularly in cases linked to chronic early-life stress.

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“…However, traumatised children have often had experiences that have left them feeling that they are unlovable and unworthy (Gregorowski & Seedat, 2013). Unless these underlying beliefs are addressed, traumatised individuals commonly have great difficulty in functioning successfully in society (Friestad, Ase-Bente, & Kjelsberg, 2012;Strine et al, 2012).…”

Section: Schools Prioritise Academic Learning Over Emotional Recoverymentioning

confidence: 99%

Helping Children With Home Education: How Home Education Can Enable Good Educational Outcomes for Children and Young People in Out-of-Home Care

Gribble

English

2016

IJCYFS

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Abstract:Children who experience maltreatment in their families may be placed in outof-home care. A large, and increasing, number of children are being raised in these settings in Australia. The history of maltreatment that children in out-of-home care have experienced results in a variety of educational challenges. It is generally believed that schools are best placed to serve the educational needs of these children. However, there is extensive evidence that schools are unable to facilitate learning success for many children in out-of-home care. This paper argues that because home education can provide a lowstress environment and individually tailored learning, it can be an effective method of education for children and young people in out-of-home care. A case study of a homeeducated child in out-of-home care is presented.

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Associations Between Adverse Childhood Experiences, Psychological Distress, and Adult Alcohol Problems

Abstract: It may be important to identify early childhood trauma and adult psychological distress in programs that focus on reducing alcohol abuse.

Cited by 180 publications

References 47 publications

Screening Adults With Substance Use Disorder for Adverse Childhood Experiences

Screening Adults With Substance Use Disorder for Adverse Childhood Experiences

Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System

Helping Children With Home Education: How Home Education Can Enable Good Educational Outcomes for Children and Young People in Out-of-Home Care

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