Associations among urodynamic findings and symptoms in women enrolled in the interstitial cystitis data base (ICDB) study

Kirkemo, Aaron; Peabody, Michelle; Diokno, Ananias C.; Afanasyev, Alexandre; Nyberg, Leroy M.; Landis, J. Richard; Cook, Yvonne L. Matthews; Simon, L

doi:10.1016/s0090-4295(99)80335-5

Cited by 72 publications

(49 citation statements)

References 8 publications

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“…3 However, it is recognized that approximately 15% of patients diagnosed with IC/BPS will demonstrate DO 53 and, thus, the coexistence of urge incontinence or DO should not preclude a diagnosis of IC/BPS. Other findings on UDS from the IC database study were a reduced first sensation to void (mean 81 ± 64 mL) and maximum sensory capacity (mean 198 ± 107 mL).…”

Section: Urodynamics (Uds) (Not Recommended In the Routine Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Cox

Golda

Nadeau

et al. 2016

CUAJ

113

121

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MethodologyThe following guidelines were based on MEDLINE and PUBMED searches of English language literature, in addition to consensus conference proceedings. Levels of evidence and grades of recommendation were assigned for each investigation and treatment, as per the modified Oxford Centre for Evidence-Based Medicine grading system. Where the literature was inconsistent or scarce, a consensus expert opinion was generated to provide treatment guidelines.

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Section: Urodynamics (Uds) (Not Recommended In the Routine Evaluationmentioning

confidence: 99%

“…33,53 If a cystoscopy under local anesthetic is planned, a functional bladder capacity and its relation to the patient's pain can be assessed with patient awake.…”

Section: Urodynamics (Uds) (Not Recommended In the Routine Evaluationmentioning

confidence: 99%

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Cox

Golda

Nadeau

et al. 2016

CUAJ

113

121

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“…Although multiple disorders may contribute to these symptoms, interstitial cystitis (IC)/painful bladder syndrome is especially troublesome because affected individuals report significant discomfort and pain in addition to urinary symptoms (Burkman 2004;Nickel 2004). Pain is the most troubling symptom to IC patients (Parsons 2002) and 94% of registrants in an IC database report pain referred to the pelvic area (Kirkemo et al 1997). No infectious agent causing IC has been identified, although bladders of many IC patients show signs of inflammation, including edema, vasodilatation, and infiltration of mast cells (Burkman 2004;Nickel 2004).…”

Section: Introductionmentioning

confidence: 99%

“…IC is associated with an increased release of adenosine triphosphate (ATP) from bladder urothelial cells (Sun et al 2001) and ATP is also released from bladder urothelium in response to stretch or bladder distension (Ferguson et al 1997;Vlaskovska et al 2001). Importantly, interactions between the urothelium and bladder nerve terminals are thought to regulate micturition and nociception (Andersson 2002;Kirkemo et al 1997;Meen et al 2001;Ness et al 2005;Tubaro 2004;Vlaskovska et al 2001), and ATP and P2X receptors have been implicated in bladder nociception (Ford et al 2006;Rapp et al 2005). For example, both P2X 2 and P2X 3 receptor knockout mice exhibit bladder hyporeflexia (Cockayne et al 2000(Cockayne et al , 2005 and recordings from bladder primary afferent fibers show attenuated responses to mechanical bladder stimulation (Vlaskovska et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Cyclophosphamide-Induced Bladder Inflammation Sensitizes and Enhances P2X Receptor Function in Rat Bladder Sensory Neurons

Dang¹,

Lamb²,

Cohen³

et al. 2008

Journal of Neurophysiology

107

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We studied sensitization of retrogradely labeled bladder sensory neurons and plasticity of P2X receptor function in a model of cystitis using patch-clamp techniques. Saline (control) or cyclophosphamide (CYP) was given intraperitoneally to rats on days 0, 2, and 4. On day 5, lumbosacral (LS, L6-S2) or thoracolumbar (TL, T12-L2) dorsal root ganglia were removed and dissociated. Bladders from CYP-treated rats showed partial loss of the urothelium and greater myeloperoxidase activity compared with controls. Bladder neurons from CYP-treated rats were increased in size (based on whole cell capacitance) compared with controls and exhibited lower activation threshold, increased action potential width, and greater number of action potentials in response to current injection or application of purinergic agonists. Most control LS bladder neurons (>85%) responded to ATP or α,β-metATP with a slowly desensitizing current; these agonists affected only half of TL neurons, producing predominantly fast/mixed desensitizing currents. CYP treatment increased the fraction of TL bladder neurons sensitive to purinergic agonists (>80%) and significantly increased current density in both LS and TL bladder neurons compared with control. Importantly, LS and TL neurons from CYP-treated rats showed a selective increase in the functional expression of heteromeric P2X 2/3 and homomeric P2X 3 receptors, respectively. Although desensitizing kinetics were slower in LS neurons from CYP-treated compared with control rats, recovery kinetics were similar. The present results demonstrate that bladder inflammation sensitizes and increases P2X receptor expression and/or function for both pelvic and lumbar splanchnic pathways, which contribute, in part, to the hypersensitivity associated with cystitis.

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“…2 However, it is recognized that about 15% of patients diagnosed with IC/PBS will demonstrate DO 39 and thus the coexistence of urge incontinence or DO should not preclude a diagnosis of IC/PBS. Other findings on UDS from the IC Database Study were a reduced first sensation to void (mean 81, standard deviation [SD] 64, mL) and maximum sensory capacity (mean 198, SD 107 mL).…”

Section: Urodynamics (Not Recommended)mentioning

confidence: 99%

Diagnosis of interstitial cystitis

Carr

Corcos

Nickel

et al. 2013

CUAJ

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Associations among urodynamic findings and symptoms in women enrolled in the interstitial cystitis data base (ICDB) study

Cited by 72 publications

References 8 publications

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Cyclophosphamide-Induced Bladder Inflammation Sensitizes and Enhances P2X Receptor Function in Rat Bladder Sensory Neurons

Diagnosis of interstitial cystitis

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