Associations among histological characteristics and patient outcomes in colorectal carcinoma with a mucinous component

González, Raúl; Cates, Justin M.; Washington, Kay

doi:10.1111/his.13748

Cited by 21 publications

(20 citation statements)

References 39 publications

(62 reference statements)

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“…In our study, the clinicopathological characteristics of HCM patients were consistent with those of stage‐matched conventional HC patients, except for higher CA19‐9 levels, larger tumor size, less differentiation, and high frequency of liver parenchyma invasion, portal vein invasion, and lymphovascular invasion. Similar to our findings, Gonzalez et al reported that CAM was correlated with larger tumor size and more positive lymph nodes. We believe that this higher tendency might be attributed to the highly aggressive biological behaviors of the mucinous component.…”

Section: Discussionsupporting

confidence: 93%

“…To date, only limited information is available regarding the association between the mucinous component and clinicopathological characteristics of solid tumors . In our study, the clinicopathological characteristics of HCM patients were consistent with those of stage‐matched conventional HC patients, except for higher CA19‐9 levels, larger tumor size, less differentiation, and high frequency of liver parenchyma invasion, portal vein invasion, and lymphovascular invasion.…”

Section: Discussionsupporting

confidence: 74%

“…However, the prognostic significance of mucinous component (less than 50% of the total tumor volume) has yet to be fully characterized. For instance, several studies have indicated that colorectal carcinoma with mucinous component (CAM) and conventional adenocarcinoma have similar outcomes, with no impact on prognosis . Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma …”

Section: Introductionmentioning

confidence: 99%

“…For instance, several studies have indicated that colorectal carcinoma with mucinous component (CAM) and conventional adenocarcinoma have similar outcomes, with no impact on prognosis. 10,17,18 Conversely, other investigators have suggested that CAM is significantly associated with a worse prognosis than conventional adenocarcinoma. 19,20 To date, there are still no data available regarding the formation of clinicopathological characteristics and prognosis in HC with a mucinous component (HCM).…”

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confidence: 97%

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Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

et al. 2019

Journal of Surgical Oncology

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Background The presence of mucinous component has been indicated to have a prognostic value in adenocarcinoma. However, little is known regarding the clinicopathological characteristics and prognosis of hilar cholangiocarcinoma (HC) with mucinous component (HCM). Methods Between January 1996 and December 2014, a total of 61 HCM patients who underwent curative‐intent resection at West China Hospital were retrospectively reviewed. The clinicopathological characteristics and survival of these patients were compared with a large cohort of 217 surgically resected conventional HC patients during the same period. Results The clinicopathological characteristics of HCM were distinct from conventional HC, including higher CA19‐9 levels, larger tumor sizes, less differentiation, and a high frequency of liver parenchyma invasion, portal vein invasion, and lymphovascular invasion. HCM patients showed significantly worse recurrence‐free survival (13.4 vs 23.9 months; P = .011) and overall survival (18.2 vs 32.1 months; P = .019) compared with conventional HC patients. Multivariate analysis confirmed liver parenchyma invasion, N stage, surgical margin, and histological grade as independent prognostic factors influencing overall survival in HCM patients. Conclusion HCM showed distinct clinicopathological features, more aggressive biological behaviors, and poor prognosis in comparison with conventional HC. Therefore, the mucinous component is an adverse prognostic factor for HC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 97%

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Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

et al. 2019

Journal of Surgical Oncology

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“…Despite several studies comparing underlying clinicopathological differences between MAC and conventional CRC. Still, controversial results relating prognostic value of mucinous histology have been reported [2][3][4][5][6][7]. Till present, the prognostic value of MAC remains undetermined when the locations of the tumor, molecular alterations, population characteristics or different treatment plans are taken into account.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics, molecular alterations and prognosis of mucinous histology in colorectal adenocarcinoma patients

Jia

Yan

2020

Preprint

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Background Mucinous adenocarcinoma (MAC) is conventionally diagnosed by WHO definition when the extracellular mucin is more than 50% of the tumour area. The study is aimed at analyzing the clinicopathological characteristics, mutation spectrum, and prognosis of the colorectal adenocarcinoma (CRC) with any mucinous proportion or feature. Methods Clinical and pathological information for 50 patients were reviewed and recorded. Mutation analyses for exon 2–4 of KRAS gene and exon 15 of BRAF gene were performed by Sanger sequencing. Expression of DNA mismatch repairs (MMRs) and P53 proteins was evaluated by immunohistochemistry (IHC). Density of tumour infiltrating lymphocyte (TIL) status was scored. We also evaluated the percentage of glands producing mucin and the morphology of the different tumor cells types in mucin pools. We retrospectively analyzed prognosis of 43 patients with Stage II-III MAC. The primary outcome was progression-free survival (PFS). Results The overall frequencies of KRAS and BRAF mutations were 37.9% and 4.4%, respectively. Patients with MAC exhibiting high levels of mucin were related to the increase of tumor diameter (P = 0.038), but were not associated with any of the other clinicopathological parameters. The proportion or variable morphology of mucinous component did not stratify PFS in Stage II-III tumours. It is interesting to note that male patients had lower TIL compared with female patients (P = 0.018). TIL-low tumors were also correlated with advanced stage (P = 0.041). TIL status was a strong independent predictor of PFS in stage II-III mucinous component tumours (p < 0.001). All four IV stage patients were also classified into TIL-low case. No parameters were independently associated with outcome after adjusting for tumour stage in multivariate analysis. Conclusions TIL status could more accurately determine the biology of the MAC feature for appropriate management, irrespective of quantity or morphology of mucinous component.

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Pattern and Significance of Tumour Budding in Colorectal Carcinomas Using ITBCC Guidelines: a Low Resource Setting Practice Observation

Ezenkwa

Ogun

Bamiro

et al. 2020

J Gastrointest Canc

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Associations among histological characteristics and patient outcomes in colorectal carcinoma with a mucinous component

Abstract: Stage-matched mCRCs and adenocarcinomas have similar outcomes, with no prognostic significance to morphological subtyping. Histological characteristics of mCRC, including percentage of tumour volume comprised of mucin, were not predictive of outcome.

Cited by 21 publications

References 39 publications

Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

Prognostic significance of mucinous component in hilar cholangiocarcinoma after curative‐intent resection

Clinicopathological characteristics, molecular alterations and prognosis of mucinous histology in colorectal adenocarcinoma patients

Pattern and Significance of Tumour Budding in Colorectal Carcinomas Using ITBCC Guidelines: a Low Resource Setting Practice Observation

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