Associations among FT&lt;sub&gt;4&lt;/sub&gt; level, FT&lt;sub&gt;3&lt;/sub&gt;/FT&lt;sub&gt;4&lt;/sub&gt; ratio, and non-alcoholic fatty liver disease in Chinese patients with hypopituitarism

Xiao, Jinfeng; Zhu, Chonggui; Zhang, Xinxin; Sun, Longhao; Gao, Chunqing; Liang, Xiaoyu; He, Qing; Liu, Ming

doi:10.1507/endocrj.ej21-0536

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…Hypothyroidism also plays a signifcant role in the development of NAFLD. Both a meta-analysis and a retrospective case analysis have reported a signifcant association between hypothyroidism and NAFLD [28,29]. Some researchers have estimated the time for progression from NAFLD to cirrhosis to be around 57 years [30].…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Analysis in Pituitary Stalk Interruption Syndrome

Guo,

Zhao,

2024

International Journal of Endocrinology

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Objective. Pituitary stalk interruption syndrome (PSIS) is characterized by the absence of pituitary stalk, pituitary hypoplasia, and ectopic posterior pituitary. Because the etiology and clinical cognition of PSIS remain elusive, we analyzed the clinical features of PSIS in Chinese patients. Methods. A retrospective analysis was conducted on the clinical presentation, laboratory data, imaging examination, and management of 24 PSIS inpatients from our center over 10 years. Results. Among the 24 PSIS patients, there were 22 males (91.7%) and 2 females (8.3%). Growth hormone deficiency was present in all 24 cases (100%), hypogonadism in 24 cases (100%), secondary adrenal insufficiency in 22 cases (91.2%), and hypothyroidism in 21 cases (87.5%). 20 cases (83.3%) of PSIS patients exhibited deficiencies in four anterior pituitary hormones, 3 cases (12.5%) exhibited deficiencies in three anterior pituitary hormones, and 1 case (4.2%) exhibited deficiencies in two anterior pituitary hormones, with none exhibiting deficiencies in posterior pituitary hormones. Among the 24 PSIS patients, 12 had a history of growth hormone therapy before admission, and 12 had no such history. Additionally, 19 cases (79.2%) with PSIS were complicated by dyslipidemia, 15 cases (62.5%) were complicated by nonalcoholic fatty liver disease, and 9 cases (37.5%) were complicated by hyperuricemia. Conclusions. PSIS often presents with growth retardation and hypogonadotropic hypogonadism, but in some cases, short stature is not exhibited. PSIS is prone to complications such as dyslipidemia, nonalcoholic fatty liver disease, and hyperuricemia, increasing the risk of cardiovascular and cerebrovascular diseases. In clinical practice, the diagnostic ability of PSIS should be improved, and pituitary function and complications should be evaluated in a timely manner to avoid delayed treatment.

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Section: Discussionmentioning

confidence: 99%

Clinical Features and Analysis in Pituitary Stalk Interruption Syndrome

Guo,

Zhao,

2024

International Journal of Endocrinology

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“…Decreased levels of FT4 and testosterone were cited as potential risk factors of NAFLD in other studies. [28][29][30] However, after adjusting for the above mentioned factors, IGF-1 remained an independent risk factor of NAFLD.…”

Section: Noninvasive Tools For the Risk Stratification Of Fibrosis In...mentioning

confidence: 92%

Relationship between growth hormone deficiency and nonalcoholic fatty liver disease in patients with pituitary stalk interruption syndrome

Huang

Wang

et al. 2022

Clinical Endocrinology

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Background Pituitary stalk interruption syndrome (PSIS), characterized by thinning or disappearance of the pituitary stalk, hypoplasia of the anterior pituitary, and an ectopic posterior pituitary, can lead to congenital combined pituitary hormone deficiency. There is a high prevalence of various metabolic disorders, including nonalcoholic fatty liver disease (NAFLD), in this population. Objective To investigate the characteristics of NAFLD in Chinese adult patients with PSIS and its association with growth hormone deficiency. Design Retrospective cross‐sectional study in a tertiary referral center of China. Patients Adult patients with PSIS diagnosed, followed up between September 2019 and August 2021, were consecutively enrolled. Measurements Abdominal ultrasonography images were evaluated and noninvasive fibrosis scores were determined to assess the severity of NAFLD. Anthropometric, clinical, and biochemical parameters were compared between patients with and without NAFLD. Logistic regression was performed to assess the independent effects of insulin‐like growth factor‐1 (IGF‐1) on NAFLD. Results A total of 93 patients (77 men, 16 women, mean age: 29.6 ± 7.1 years) were included. The prevalence of NAFLD and advanced fibrosis/cirrhosis was 50.5% and 4.3%, respectively. Insufficient hormone therapy and prominent metabolic disorders, including central obesity, dyslipidemia, insulin resistance, and metabolic syndrome, were more common in the NAFLD (+) group. After adjusting for multiple variables, IGF‐1 <−2 standard deviation score (SDS) was found to be associated with an increased prevalence of NAFLD (odds ratio [OR]: 4.92, 95% confidence interval [CI]: 1.21–24.55, p = .035). Per 1 SDS increase in IGF‐1 was associated with a 27% lower risk of NAFLD (OR: 0.73, 95% CI: 0.52–0.97, p = .042). Conclusion NAFLD is a frequent comorbidity among Chinese adult patients with PSIS and is strongly associated with lower IGF‐1 levels. Timely and appropriate hormone replacement, particularly growth hormone may contribute to decreasing the risk of NAFLD in these patients.

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Associations among FT<sub>4</sub> level, FT<sub>3</sub>/FT<sub>4</sub> ratio, and non-alcoholic fatty liver disease in Chinese patients with hypopituitarism

Cited by 2 publications

References 41 publications

Clinical Features and Analysis in Pituitary Stalk Interruption Syndrome

Clinical Features and Analysis in Pituitary Stalk Interruption Syndrome

Relationship between growth hormone deficiency and nonalcoholic fatty liver disease in patients with pituitary stalk interruption syndrome

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