Associations among environmental exposure to manganese, neuropsychological performance, oxidative damage and kidney biomarkers in children

Nascimento, Sabrina; Baierle, Marília; Göethel, Gabriela; Barth, Anelise; Brucker, Natália; Charão, Mariele Feiffer; Saüer, Elisa; Gauer, Bruna; Arbo, Marcelo Dutra; Altknecht, Louise; Jager, Márcia Elisa; Dias, Ana Cristina Garcia; Salles, Jerusa Fumagalli de; Pierre, Tatiana Saint’; Gioda, Adriana; Moresco, Rafael Noal; García, Solange Cristina

doi:10.1016/j.envres.2016.01.035

Cited by 59 publications

(34 citation statements)

References 65 publications

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“…With one exception (Mora et al 2015), most epidemiologic studies that assessed childhood Mn exposure and learning and memory were cross-sectional in design and contained no prenatal or postnatal Mn measurements (Haynes et al 2015; Hernández-Bonilla et al 2016; Nascimento et al 2016; Oulhote et al 2014a; Torres-Agustín et al 2013; Wasserman et al 2011; Wright et al 2006). …”

Section: Introductionmentioning

confidence: 99%

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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Background Manganese (Mn) is an essential element required for growth and development, but higher body burdens have been associated with neurobehavioral decrements in children. Objectives We examined whether prenatal or postnatal Mn measured in deciduous teeth was associated with scores on a test of visuospatial learning and memory. Methods Deciduous teeth were collected from 142 participants (ages 10–14 years) residing near varied ferro-manganese industry in Italy. Mn concentrations were measured in prenatal and postnatal tooth regions by laser ablation inductively coupled plasma mass spectrometry (ICP-MS). The Virtual Radial Arm Maze (VRAM), an animal-human analogue task, was used to assess visuospatial learning and memory. We used generalized additive, linear and zero-inflated Poisson mixed regression models to estimate associations between prenatal or postnatal Mn concentrations and repeated measures of all four VRAM outcomes: time, distance, working and reference memory errors. Effect measure modification by sex was examined in stratified models. Results U-shaped associations between prenatal Mn and VRAM outcomes were observed among girls only (pGAMM =0.001 to 0.02 in stratified models). Compared to the mid-tertile of prenatal Mn, girls in the highest tertile took 7.7 seconds [95% CI: −6.1, 21.5] longer to complete the task, traveled 2.3 maze units [0.1, 4.4] farther, and committed more working and reference memory errors (β for count ratio=1.33 [1.01, 1.83]; 1.10 [0.98, 1.24], respectively). This association was not observed among boys. In contrast, for postnatal Mn, no significant associations were found, and patterns were similar for boys and girls. Conclusions The prenatal period may be a critical window for the impact of environmental Mn on visuospatial ability and executive function, especially for females.

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Section: Introductionmentioning

confidence: 99%

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Bauer

Henn

Austin

et al. 2017

Environment International

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“…manganese (Nascimento et al, 2016), mercury (Barregard et al, 2008; de Burbure et al, 2006; Woods et al, 2008; Geier et al, 2013; Bellinger et al, 2006; DeRouen et al, 2006), selenium (Skroder et al, 2015), thallium (Weaver et al, 2014), or uranium (Weaver et al, 2014) (Table 2). These studies covered Egypt, France, Poland, Czech Republic, Portugal, China, Bangladesh, Mexico, Thailand, Brazil, and the United States.…”

Section: Resultsmentioning

confidence: 99%

“…One study reported on the effects of manganese. A cross-sectional study of 63 children in Brazil found a significant increase in urine albumin and urine NAG levels between urban and rural children, with rural children having higher levels of blood, hair, and drinking water manganese (Nascimento et al, 2016). However, this study was comprised of a small number of participants and did not control for potential confounders for kidney function biomarkers (Nascimento et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Environmental exposures and pediatric kidney function and disease: A systematic review

Zheng

Sanders

Saland

et al. 2017

Environmental Research

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Background Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. Methods We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. Results We found 50 studies that met the search criteria and were included in this systematic review. Environmental exposures reviewed herein included lead, cadmium, mercury, arsenic, fluoride, aflatoxin, melamine, environmental tobacco, bisphenol A, dental procedures, phthalates, ferfluorooctanoic acid, triclosan, and thallium/uranium. Most studies assessed environmental chemical exposure via biomarkers but four studies assessed exposure via proximity to emission source. There was mixed evidence of association between metal exposures, and other non-metal environmental exposures and pediatric kidney disease and other kidney disease biomarkers. The evaluation of causality is hampered by the small numbers of studies for each type of environmental exposure, as well as lack of study quality and limited prospective evidence. Conclusion There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes.

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“…High levels of Mn from drinking water can affect inhibitory control (Nascimento et al 2016). Similarly, in Brazilian children living near a ferromanganese alloy plant, airborne Mn exposure was associated to lower IQ and neuropsychological performance in tasks of inhibition responses, strategic visual formation, and verbal working memory (Carvalho et al 2014).…”

Section: Effects On Cognitive Functionsmentioning

confidence: 99%

Manganese and Developmental Neurotoxicity

Lucchini

Placidi

Cagna

et al. 2017

Advances in Neurobiology

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Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and executive functions through the involvement of the frontal cortex. Neurodevelopmental disturbances are increasing in the society, and understanding the potential role of environmental determinants is a key for prevention. Therefore, assessing the environmental sources of Mn exposure and the mechanisms of developmental neurotoxicity and defining appropriate biomarkers of exposure and early functional alterations represent key issues to improve and address preventive strategies. These themes will be reviewed in this chapter.

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Associations among environmental exposure to manganese, neuropsychological performance, oxidative damage and kidney biomarkers in children

Cited by 59 publications

References 65 publications

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility

Environmental exposures and pediatric kidney function and disease: A systematic review

Manganese and Developmental Neurotoxicity

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