Association Vitamin D Receptor (TaqI) Gene Polymorphism with Anthropometric Parameters and Blood Pressure of College Students in Faculty of Medicine, University of Sumatera Utara

Abstract

Abstract-Epidemiological studies suggest several genes from the vitamin D receptor have been implicated in obesity and cardiovascular disease. However, the findings were inconsistent.The aim of this study was to evaluate TaqI polymorphism of the vitamin D receptor (VDR) gene are associated with anthropometric parameters and blood pressure on college students in Faculty of Medicine, Sumatera Utara University.This was a cross-sectional study. Measurements of anthropometric parameters were carried out. Blood pressure measurement using a mercury sphygmomanometer. TaqI polymorphiss of VDR gene were geno-typed by PCR and FRLP. Statistical analysis were calculated using SPPS software (version 14.0).The prevalence of TaqI genotypes were 117 (84%) TT and 22 (16%) Tt. Homozygous tt was not found in the subjects. There were no significant differences in anthropometric parameters (BMI and WHR) and blood pressure between TaqI polymorphism of the VDR gene (p=0.321; p=0.607; p=0.278)The results suggest that TaqI VDR polymorphism are not related with the obesity and not risk factor of cardiovascular disease on college students in