Association Study of Three Gene Polymorphisms Recently Identified by a Genome-Wide Association Study with Obesity-Related Phenotypes in Chinese Children

Abstract

Objective: This study aimed to examine associations of three single-nucleotide polymorphisms (SNPs) with obesity-related phenotypes in Chinese children. These SNPs were identified by a recent genome-wide association (GWA) study among European children. Given that varied genetic backgrounds across different ethnicity may result in different association, it is necessary to study these associations in a different ethnic population. Methods: A total of 3,922 children, including 2,191 normal-weight, 873 overweight and 858 obese children, from three independent studies were included in the study. Logistic and linear regressions were performed, and meta-analyses were conducted to assess the associations between the SNPs and obesity-related phenotypes. Results: The pooled odds ratios of the A-allele of rs564343 in PACS1 for obesity and severe obesity were 1.180 (p = 0.03) and 1.312 (p = 0.004), respectively. We also found that rs564343 was nominally associated with BMI, BMI standard deviation score (BMI-SDS), waist circumference, and waist-to-height ratio (p < 0.05). Conclusions: We showed for the first time that the rs564343 in PACS1 was associated with risk of severe obesity in a non-European population. This SNP was also found to be associated with common obesity and various obesity-related phenotypes in Chinese children, which had not been reported in the original study. The results demonstrated the value of conducting genetic researches in populations with different ethnicity.

Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity

“…Several obesity‐related risk factors such as lifestyle, related syndromes, pregnancy, and sleep duration affect miRNA dysregulation 15–19 which consequently regulate obesity‐associated genes or play a role in obesity‐associated cancers such as CRC 12,20,21 . The genetic factors are involved in biological processes, body composition, body weight regulation, body mass index (BMI), and obesity 22–26 . The variants in the miRNA binding site are potential markers of obesity and its associated cancers 27–29 .…”

“… 12 , 20 , 21 The genetic factors are involved in biological processes, body composition, body weight regulation, body mass index (BMI), and obesity. 22 , 23 , 24 , 25 , 26 The variants in the miRNA binding site are potential markers of obesity and its associated cancers. 27 , 28 , 29 They may alter gene expression 30 , 31 , 32 or affect the risk and survival of individuals with various multifactorial diseases, such as CRC.…”