Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

“…5), indicating that more severe symptoms of depression are associated with lower SERT availability. These findings are similar but not identical to previous results [116][117][118]122], probably due to heterogeneous demographic and clinical characteristics, different radioligands, and methodological differences. More importantly, they also reported that the depressed suicidal group had a higher PFC/midbrain SERT binding ratio than both the depressed non-suicidal and control groups (Fig.…”

“…Altered SERT has been reported in MDD patients [116][117][118], and has been considered to be involved in the pathophysiology of depression [119] and suicide [115]. Recently, a study by Yeh et al [120] …”

Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[18F]-ADAM PET study

“…This finding suggests that high suicidal ideation may obscure the MDD-related reduction in SeRT binding. This may lead to contradictory results for SeRT binding in patients with depression, as have been reported by previous studies (ichimiya et al 2002;Lindstrom et al 2004;Meyer et al 2004;Reivich et al 2004;newberg et al 2005;Parsey et al 2006;Ryding et al 2006;Cannon et al 2007;Reimold et al 2008;Selvaraj et al 2011;ho et al 2013;Miller et al 2013). …”

“…a bipolar depression may have existed in these early-onset depression, even though they only displayed unipolar depressive episodes and denied prior hypomania or mania during a semi-structured interview. use of a mixed sample of subjects with unipolar (ichimiya et al 2002;Cannon et al 2007;Selvaraj et al 2011;ho et al 2013;Miller et al 2013;nye et al 2013), and bipolar depression (Cannon et al 2006;oquendo et al 2007;Chou et al 2010) may have confounded our results. Finally, although SeRT BP decreased in the MDD group, it was not correlated with the severity of depression, which was measured by hDRS.…”

Variants of SLC6A4 in depression risk following severe TBI

“…While this behavioural adaptation could be advantageous in some aspects, it may also pre-dispose S-carriers to mood disorders [12][13][14]. Recently, Ho et al [43] showed that SERT availability was reduced in subjects with major depression, but that this was not associated with SLC6A4 genotype. Similarly, Kobiella et al [44] showed recently that 5-HTT binding potential did not mediate the relationship between 5-HTTLPR and amygdala reactivity, suggesting that 5-HTTLPR may not have a direct effect on 5-HTT availability.…”