Association study of miR-149 rs2292832 and miR-608 rs4919510 and the risk of hepatocellular carcinoma in a large-scale population

Abstract

Polymorphisms in pre‑microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development. The present study aimed to evaluate whether miR‑149 rs2292832 (C>T) and miR‑608 rs4919510 (G>C) are associated with the risk and clinical characteristics of hepatocellular carcinoma (HCC) in a large‑scale population. miR‑149 rs2292832 and miR‑608 rs4919510 were genotyped in a total of 993 patients with HCC and 992 unrelated healthy subjects by Sequenom MassARRAY. The results showed that, compared with the reference CC genotype, the TC+TT genotype of miR‑149 was more highly associated with HCC [CC vs. TC+TT: Odds ratio (OR)=1.384, 95% confidence interval (CI)=1.013‑1.892, P=0.041], and was also associated with an increased risk of hepatitis B virus (HBV)‑associated HCC (CC vs. TC+TT: OR=1.453, 95% CI=1.034‑2.042, P=0.031). However, no significant association between miRNA‑608 rs4919510 and the risk of HCC/HBV‑associated HCC was found. In addition, these two SNPs were shown not to be correlated with a range of clinical characteristics. The present study may provide an indicator for identification of the high risk of HCC in patients.

Systematic evaluation of cancer risk associated with rs2292832 in miR-149 and rs895819 in miR-27a: a comprehensive and updated meta-analysis

“…After further identification and screening individual study, 43 articles (49 studies) [11–53] underwent full-text assessment, and 6 articles (10 studies, not including one site according to HWE) [14, 17, 19, 20, 35, 42] were excluded due to inconsistently with HWE. Finally, 37 articles (40 studies) [11–13, 15, 16, 18, 21–34, 36–41, 43–53] were conducted in quantitative synthesis.…”

“…A total of 39 eligible studies met the prespecified inclusion criteria, in which two articles [24, 52] included two tumor types respectively, and one article included [23] rs2292832 and rs895819. As for rs2292832, involving 9,994 cases and 10,757 controls were ultimately analyzed from 21 studies (20 articles) [11–13, 15, 16, 18, 21–34], and 19 studies (17 articles) [23, 36–41, 43–53] involving 7,800 cases and 9,060 controls for rs895819.…”

Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV‐related liver complications: A study in a Saudi Arabian population

“…performed a meta‐analysis and found that miR‐196a2 rs11614913 was associated with susceptibility to HBV infection, whereas no evidence of association was found between miR‐146a rs2910164, miR‐499 rs3746444, and miR‐149 rs2292832 with hepatitis B risk. However, a different study found that miR‐149 rs2292832 was associated with HBV‐related HCC . In addition, Su et al., (2015) recently identified an association between miR‐146a rs2910164 and the development of HCC in an Asian population.…”

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

“…Increasing studies have revealed that lncRNAs have important influence in tumorigenesis, metastasis, and prognosis and drug resistance of gastric cancer [1]. While the functional role and molecular mechanism of many GCassociated lncRNAs remain undetermined, recent studies revealed that several lncRNAs are associated with GC progression, such as H19, FENDRR, and MRUL [14][15][16].…”