Association study of IL-10 and IFN-γ gene polymorphisms in Iranian women with preeclampsia

Kamali-Sarvestani, Eskandar; Kiany, Simin; Gharesi‐Fard, Behrouz; Robati, Minoo

doi:10.1016/j.jri.2006.04.001

Cited by 49 publications

(37 citation statements)

References 43 publications

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“…Taking these results together, we propose that differences in the frequency of alleles and genotypes described in previous reports (Hefler et al, 2001;Lachmeijer et al, 2002;Faisel et al, 2003;Freeman et al, 2004;Stonek et al, 2008;Haggerty et al, 2005;Daher et al, 2006;Kamali-Sarvestani et al, 2006;Saarela et al, 2006;Vural et al, 2010), and in this study, may be due to genetic background, since it is known that Mexican populations are constituted by a genetic admixture among Amerindians, Caucasian, and Black genes. The general pattern has a high Amerindian ancestry, followed by Caucasian and Black ancestry (Lisker et al, 1990).…”

Section: Discussionsupporting

confidence: 74%

“…Although this is one of the few studies that have included a significant number of women with PE (411 women) and controls (613 women), resulting in a good statistical power to find out whether MexicanMestizo and Mayan-Mestizo women present the same effects as seen in women with PE in other populations (Freeman et al, 2004;Kamali-Sarvestani et al, 2006;Vural et al, 2010), we found no significant associations or interactions between these polymorphisms and the presence of PE in our studied populations.…”

Section: Discussioncontrasting

confidence: 59%

“…Haggerty et al, (2005) analyzed the -1082G/A polymorphism in white women with PE, and observed that women homozygous for the -1082A allele were more likely to be preeclamptic; however, these results were not statistically significantly different. Likewise, Kamali-Sarvestani et al (2006) studied the relationship between the same polymorphism of IL-10 in Iranian women with PE, and observed contradictory results to those reported by Haggerty et al (2005), since the -1082G allele in a homozygous trait was significantly associated with PE. Furthermore, Stonek et al (2008) analyzed the same polymorphism in Caucasian women, finding that the G allele was more frequent in the pre-eclamptic group than among controls, but these results were not statistically significant.…”

Section: Discussionmentioning

confidence: 90%

“…Moreover, it has been suggested that polymorphisms in regulatory regions of cytokine genes affect the level of cytokine expression and may be related to predisposition and/or different clinical features or the outcomes of the diseases (Bidwell et al, 2001). Several polymorphisms have been studied in relation with PE, for example, the single-nucleotide polymorphism rs1800896 located in the promoter region of the IL-10 gene (de Groot et al, 2004;Haggerty et al, 2005;Daher et al, 2006;Kamali-Sarvestani et al, 2006;Vural et al, 2010), the rs1800795 in the promoter region of the IL-6 gene (Freeman et al, 2004;Saarela et al, 2006), and the variable number of tandem repeats (VNTR) of 86 base pairs (bp) in intron 2 of IL-1Ra (Hefler et al, 2001;Lachmeijer et al, 2002;Faisel et al, 2003).…”

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confidence: 99%

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Analysis of Polymorphisms in Interleukin-10, Interleukin-6, and Interleukin-1 Receptor Antagonist in Mexican-Mestizo Women with Pre-eclampsia

Villalvazo

Canto-Cetina²,

Arauz³

et al. 2012

Genetic Testing and Molecular Biomarkers

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Due to the fact that studies seeking associations of polymorphisms in regulatory regions of cytokine genes with pre-eclampsia (PE) have not always been consistent in different population analyses, the aim of this study was to investigate the possible association between rs1800896 of interleukin-10 (IL-10), rs1800795 of interleukin-6 (IL-6), and the variable number of tandem repeats (VNTR) in intron 2 of interleukin-1 receptor antagonist (IL-1Ra), as well as gene-gene interactions between these three polymorphisms with the presence of PE in Mexican-Mestizo women and one Amerindian population from México (Maya). A case-control study was performed where 411 pre-eclamptic cases and 613 controls were genotyped. For the rs1800896 of IL-10 and rs1800795 of IL-6, we used real-time polymerase chain reaction (PCR) allelic discrimination and for the VNTR of IL-1Ra, PCR. Allele frequency differences were assessed by Chi-squared test; logistic regression was used to test for associations; a gene-gene interaction was conducted. Genotypic and allelic distribution of the polymorphisms was similar in our population. The estimated of the gene-gene interaction between the polymorphisms did not differ significantly. However, we observed important differences in the distribution of the alleles and genotypes of the three polymorphisms analyzed between Mestiza-Mexicanas and Maya-Mestizo women. In conclusion, we did not find an association between polymorphisms in IL-10, IL-6, and IL-1Ra and PE in Mexican-Mestizo and MayaMestizo women. To our knowledge, this is the first time that these three polymorphisms were analyzed together with gene-gene interaction in women with PE.

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Section: Discussionsupporting

confidence: 74%

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Polymorphisms in Interleukin-10, Interleukin-6, and Interleukin-1 Receptor Antagonist in Mexican-Mestizo Women with Pre-eclampsia

Villalvazo

Canto-Cetina²,

Arauz³

et al. 2012

Genetic Testing and Molecular Biomarkers

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“…Other studies link an increase in IL-15 levels, stimulation of dNK cells and release of IFN-γ to higher incidence of miscarriages and PE [80]. IFN-γ levels increase in plasma, leukocytes and decidua of women with PE [80] likely due to the presence of +874 T allele in the first intron of the IFN-γ gene [81]. Also, dNK cells release the pro-inflammatory cytokine IL-17 which may cause vascular changes and HTN in PE [82].…”

Section: Introductionmentioning

confidence: 99%

Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia

Shah

Khalil

2015

Biochemical Pharmacology

151

124

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Preeclampsia is a pregnancy-associated disorder characterized by hypertension, and could lead to maternal and fetal morbidity and mortality; however, the pathophysiological mechanisms involved are unclear. Predisposing demographic, genetic and environmental risk factors could cause localized abnormalities in uteroplacental cytoactive factors such as integrins, matrix metalloproteinases, cytokines and major histocompatibility complex molecules leading to decreased vascular remodeling, uteroplacental vasoconstriction, trophoblast cells apoptosis, and abnormal development of the placenta. Defective placentation and decreased trophoblast invasion of the myometrium cause reduction in uteroplacental perfusion pressure (RUPP) and placental ischemia/hypoxia, an important event in preeclampsia. RUPP could stimulate the release of circulating bioactive factors such as the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin that cause imbalance with the pro-angiogenic factors vascular endothelial growth factor and placental growth factor, or cause the release of inflammatory cytokines, reactive oxygen species, hypoxia-induced factor-1 and AT1 angiotensin receptor agonistic autoantibodies. The circulating bioactive factors target endothelial cells causing generalized endotheliosis, endothelial dysfunction, decreased vasodilators such as nitric oxide and prostacyclin and increased vasoconstrictors such as endothelin-1 and thromboxane A2, leading to increased vasoconstriction. The bioactive factors also stimulate the mechanisms of VSM contraction including Ca2+, protein kinase C, and Rho-kinase and induce extracellular matrix remodeling leading to further vasoconstriction and hypertension. While therapeutic options are currently limited, understanding the underlying mechanisms could help design new interventions for management of preeclampsia.

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Association of interleukin-10 gene promoter polymorphism in spontaneous abortions: a family-based triad study

Vidyadhari

Sujatha

Krupa³

et al. 2015

Inflamm. Res.

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Association study of IL-10 and IFN-γ gene polymorphisms in Iranian women with preeclampsia

Cited by 49 publications

References 43 publications

Analysis of Polymorphisms in Interleukin-10, Interleukin-6, and Interleukin-1 Receptor Antagonist in Mexican-Mestizo Women with Pre-eclampsia

Analysis of Polymorphisms in Interleukin-10, Interleukin-6, and Interleukin-1 Receptor Antagonist in Mexican-Mestizo Women with Pre-eclampsia

Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia

Association of interleukin-10 gene promoter polymorphism in spontaneous abortions: a family-based triad study

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