Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders

Liu, Zhongchun; Zhu, Fan; Wang, Gaohua; Xiao, Zheman; Tang, Jihua; Liu, Wanhong; Wang, Huiling; Líu, Hao; Wang, Xiaoping; Ying-liang, WU; Cao, Zhijian; Li, Wenxin

doi:10.1016/j.neulet.2006.12.013

Cited by 135 publications

(88 citation statements)

References 22 publications

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“…These light curves at the radio, IR, optical, and X-ray bands are sampled sparsely and unequally for S5 0716+714. Thus, as in previous research on unequally sampled light curves (Liu et al 2008(Liu et al , 2011a(Liu et al , 2011b, time lags will be analyzed by the ZDCF. From these ZDCF profile bumps closer to the zero lag, the centroid time lags τ cent , which are used as the estimation of the time lag, are computed using all points with correlation coefficients r 0.8r max .…”

Section: Time Lagsmentioning

confidence: 99%

MULTIWAVELENGTH VARIABILITY PROPERTIES OFFERMIBLAZAR S5 0716+714

Liao

Bai

Liu

et al. 2014

ApJ

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S5 0716+714 is a typical BL Lacertae object. In this paper we present the analysis and results of long-term simultaneous observations in the radio, near-infrared, optical, X-ray, and γ -ray bands, together with our own photometric observations for this source. The light curves show that the variability amplitudes in γ -ray and optical bands are larger than those in the hard X-ray and radio bands and that the spectral energy distribution (SED) peaks move to shorter wavelengths when the source becomes brighter, which is similar to other blazars, i.e., more variable at wavelengths shorter than the SED peak frequencies. Analysis shows that the characteristic variability timescales in the 14.5 GHz, the optical, the X-ray, and the γ -ray bands are comparable to each other. The variations of the hard X-ray and 14.5 GHz emissions are correlated with zero lag, and so are the V band and γ -ray variations, which are consistent with the leptonic models. Coincidences of γ -ray and optical flares with a dramatic change of the optical polarization are detected. Hadronic models do not have the same natural explanation for these observations as the leptonic models. A strong optical flare correlating a γ -ray flare whose peak flux is lower than the average flux is detected. The leptonic model can explain this variability phenomenon through simultaneous SED modeling. Different leptonic models are distinguished by average SED modeling. The synchrotron plus synchrotron selfCompton (SSC) model is ruled out because of the extreme input parameters. Scattering of external seed photons, such as the hot-dust or broad-line region emission, and the SSC process are probably both needed to explain the γ -ray emission of S5 0716+714.

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Section: Time Lagsmentioning

confidence: 99%

MULTIWAVELENGTH VARIABILITY PROPERTIES OFFERMIBLAZAR S5 0716+714

Liao

Bai

Liu

et al. 2014

ApJ

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“…The CRHR1 rs242941 G/G genotype and one haplotype block including two other SNPs, rs1876828 and rs242939, were associated with response to fluoxetine [156,157]. These results were not confirmed by the following studies [158,159].…”

Section: Crh Receptors (Crhr1 and Crhr2)mentioning

confidence: 77%

Pharmacogenetics of antidepressant drugs: An update

Crisafulli¹,

Drago²,

Calabrò³

et al. 2014

Hosp Pharm Int Multi J

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SUMMARYPharmacological treatment of depressive disorders is characterized by poor predictability of individual response. In recent years, the increasing evidence has demonstrated that genetic factors play a critical role in determining the differences in treatment outcome to antidepressant drugs. A number of pharmacogenetic studies on antidepressant drugs has been conducted, and genetic variations at level of drug metabolizing enzymes, drug transporters and drug targets, possibly influencing the clinical response, have been identified. Pharmacogenetics may hopefully provide the basis for individualized pharmacotherapy of depressive disorders in order to maximize the probability of a favorable response and minimize the risk of adverse drug reactions. In this article, the major findings related to the pharmacogenetics of genes involved in the pharmacokinetics and pharmacodynamics of antidepressant drugs are critically reviewed.

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“…Single nucleotide polymorphisms (SNPs) of the CRHR1 gene have been associated with depressive disorders in adults with a history of childhood abuse [17][18][19][20], with the severity of depressive symptoms and suicide risk [21,22], and with the response to antidepressants [23]. Five CRHR1 polymorphisms (rs17689966, rs173365, rs7209436, rs110402, and rs242924) have been associated with depressive disorders, and the TAT haplotype in SNPs rs7209436, rs110402, and rs242924 has been found with increased frequency in depressed patients compared with controls [24].…”

Section: Participantsmentioning

confidence: 99%

Implications of Polymorphisms in the CRHR1 Gene on the Hypothalamic-Pituitary-Adrenal Axis Functioning in Postpartum Depression

Rezende¹,

Figueiredo²,

Garcia-Leal³

et al. 2018

Neuropsychiatry

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Objective:This study was aimed at assessing the association of the TAT haplotype of the corticotropinreleasing hormone receptor type 1 (CRHR1) with the function of the hypothalamic-pituitaryadrenal (HPA) axis in depressive and euthymic women in the remote postpartum period. Methods:The sample (mean age = 27.9 ± 5.3 years) consisted of 37 depressed postpartum women, of which 26 had one or two copies of the TAT haplotype (D-TAT ) and 20 without the TAT haplotype (E-TAT 0 ). Salivary cortisol samples were collected immediately upon awakening and 30 minutes, 3 hours and 12 hours later, approximately in the sixth month after delivery (mean = 169.6 ± 60.3 days). DNA for genotyping was extracted between 22 and 25 weeks of pregnancy. Results: D-TAT1/2 women presented lower cortisol awakening response (CAR) compared with E-TAT 1/2 and E-TAT 0 women. Independently of the diagnosis of depression, only women with at least one copy of the TAT haplotype presented a negative correlation between CAR and scores of perceived stress during pregnancy and depressive symptoms in the postpartum. Conclusion:The association between CRHR1 polymorphisms and postpartum depression may be mediated by variability in individual responses to stress as assessed through HPA axis responsiveness.

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Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders

Cited by 135 publications

References 22 publications

MULTIWAVELENGTH VARIABILITY PROPERTIES OFFERMIBLAZAR S5 0716+714

MULTIWAVELENGTH VARIABILITY PROPERTIES OFFERMIBLAZAR S5 0716+714

Pharmacogenetics of antidepressant drugs: An update

Implications of Polymorphisms in the CRHR1 Gene on the Hypothalamic-Pituitary-Adrenal Axis Functioning in Postpartum Depression

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