Association study of Catechol-O-Methyltransferase (<i>COMT</i>) rs4680 Val158Met gene polymorphism and suicide attempt in Mexican adolescents with major depressive disorder

Sanabrais-Jiménez, Marco Antonio; Aguilar-Garcı́a, Alejandro; Hernández-Muñoz, Sandra; Sarmiento, Emmanuel; Ulloa, Rosa Elena; Jiménez-Anguiano, Anabel; Camarena, Beatríz

doi:10.1080/08039488.2021.1945682

Cited by 7 publications

(11 citation statements)

References 35 publications

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“…Du et al [ 23 ] found a combined 3R/3R and 3R* genotypic frequency of 37.2%, similar to Yu et al [ 33 ] who estimated 35.1%, while Lung et al [ 27 ], in turn, found a 41.2% frequency and Sanabrais-Jiménez et al [ 36 ] a 26.6% frequency. The highest frequency estimated was 47.3% by Huang et al [ 30 ], in contrast, the lowest frequency was 13.1%, estimated by Rivera et al [ 26 ].…”

Section: Resultssupporting

confidence: 52%

“…Of articles analyzed in this study, 57.1% (4) had at least 75% (16.5) or more items and were considered of good quality [ 26 , 27 , 30 , 33 ]. The lowest score was 68.2% (15 items) [ 36 ] Table S3 summarizes the selected articles’ selection criteria for MDD and control groups, the participants’ ethnicity/race, and the articles’ employed statistical analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The 4R allele also appeared to indirectly affect suicide attempts associated with depressive symptoms (structural equation modeling, SEM ~ MAOA-depression: b = −0.12, p = 0.031; depression-suicide: b = 0.32, p < 0.001), conferring a vulnerability to suicide in MDD men [ 27 ]. Similarly, Sanabrais-Jiménez et al [ 36 ] investigated SLC6A4 (5HTTLPR/rs25531), DRD2 (rs6275), COMT (rs4680) , and MAOA uVNTR polymorphisms’ influences on suicide attempts in Mexican adolescents diagnosed with MDD (DSM-IV major depression). However, unlike Lung et al [ 27 ], the MAOA uVNTR variant did not correlate with suicide attempts in these patients (females—genotype: X 2 = 0.86, p = 0.64; allele: X 2 = 0, p = 1 | males—X 2 = 0.008, p = 0.92)—results compatible with those found by Hung et al [ 42 ] in his metanalysis.…”

Section: Discussionmentioning

confidence: 99%

“…We considered the study quality adequate if it had at least 75% (15) of the items, and all articles included in this review met this criterion. All articles [ 23 , 26 , 27 , 30 , 33 , 34 , 36 ] described the participants’ eligibility criteria and sources and methods of selecting participants. They also made a generalized discussion and, when pertinent, revealed the importance of their study.…”

Section: Discussionmentioning

confidence: 99%

“…They also made a generalized discussion and, when pertinent, revealed the importance of their study. Nevertheless, for instance, 71.4% [ 23 , 27 , 33 , 34 , 36 ] examined their limitations, one (14,3%) did not report their population’s demographic and clinical characteristics [ 30 ], and none specified how they handled missing data in the analysis.…”

Section: Discussionmentioning

confidence: 99%

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MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review

Gonçalves

Siqueira

Duarte

et al. 2022

Cells

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Major Depressive Disorder (MDD) is a highly prevalent multifactorial psychopathology affected by neurotransmitter levels. Monoamine Oxidase A (MAOA) influences several neural pathways by modulating these levels. This systematic review (per PRISMA protocol and PECOS strategy) endeavors to understand the MAOA uVNTR polymorphism influence on MDD and evaluate its 3R/3R and 3R* genotypic frequencies fluctuation in MDD patients from different populations. We searched the Web of Science, PubMed, Virtual Health Library, and EMBASE databases for eligible original articles that brought data on genotypic frequencies related to the MAOA uVNTR variant in patients with MDD. We excluded studies with incomplete data (including statistical data), reviews, meta-analyses, and abstracts. Initially, we found 43 articles. After removing duplicates and applying the inclusion/exclusion criteria, seven articles remained. The population samples studied were predominantly Asians, with high 3R and 4R allele frequencies. Notably, we observed higher 3R/3R (female) and 3R* (male) genotype frequencies in the healthy control groups and higher 4R/4R (female) and 4R* (male) genotype frequencies in the MDD groups in the majority of different populations. Despite some similarities in the articles analyzed, there is still no consensus on the MAOA uVNTR variant’s role in MDD pathogenesis.

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Section: Resultssupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MAOA uVNTR Genetic Variant and Major Depressive Disorder: A Systematic Review

Gonçalves

Siqueira

Duarte

et al. 2022

Cells

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Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: The present study and meta‐analysis

Hasegawa

Tanifuji

Okazaki

et al. 2023

Neuropsychopharm Rep

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BackgroundOne potential cause of suicide is serotonergic dysfunction. Sex differences have been reported to modulate the effects of serotonergic polymorphisms. Monoamine oxidase A (MAOA) is an enzyme that degrades serotonin and is located on the X chromosome. A previous study indicated that the upstream (u) variable number of tandem repeat (VNTR) in the MAOA gene promoter may be associated with suicide. However, a meta‐analysis showed that this polymorphism may not be related to suicide. According to a recent study, compared with the uVNTR, the distal (d)VNTR and the haplotypes of the two VNTRs modulate MAOA expression.MethodsWe examined the two VNTRs in the MAOA gene promoter in 1007 subjects who committed suicide and 844 healthy controls. We analyzed the two VNTRs using fluorescence‐based polymerase chain reaction assays. We conducted a meta‐analysis for the two VNTRs to update it.ResultsOur results demonstrated that neither the genotype‐based associations nor allele/haplotype frequencies of the two VNTRs were significantly associated with suicide. In the meta‐analysis, we did not indicate relationships between uVNTR and suicide nor did we identify articles analyzing dVNTR in suicide.ConclusionOverall, we did not find a relationship between the two VNTRs in the MAOA promoter and suicide completion; thus, warranting further studies are required.

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