Association study between obsessive–compulsive disorder and serotonergic candidate genes

Sáiz, Pilar A.; García-Portilla, María Paz; Arango, Celso; Morales, Blanca; Bascarán, María Teresa Bobes; Martínez-Barrondo, S.; Flórez, Gerardo; Sotomayor, Emilio; Paredes, Begoña; Álvarez, César Soriano; Narciso, Gema San; Carreño, Eduardo; Bombín, Igor; Álvarez, Victoria; Coto, Eliécer; Fernández, Juan M.; Bousoño, Manuel; Bobes, Julio

doi:10.1016/j.pnpbp.2007.12.005

Cited by 49 publications

(20 citation statements)

References 52 publications

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“…Some studies show an association between OCD and AA allele polymorphism -1438 G/A in women 16,17 and in a sample of children and adolescents 18 . These results were not replicated in other studies 15,19 . Liu et al studied a sample of 103 Chinese trios and found a significant association between OCD and 5HT2A polymorphism-1438G/A (p = 0.0389), and a transmission disequilibrium in the late-onset group (p = 0.0132) and in the male group (p = 0.0255) 20 .…”

Section: Genes Related To Serotonincontrasting

confidence: 88%

Estudos de associação genética no transtorno obsessivo-compulsivo

Sampaio¹,

Lins²,

Daltro-Oliveira³

et al. 2013

Rev. psiquiatr. clín.

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Background: Obsessive-compulsive disorder (OCD) segregates in families. It follows a complex model of genetic transmission, which involves the influence of several small effect genes interacting with the environment. Methods: A systematic review of genetic association studies in OCD was performed. Articles published until 2012 were searched in the databases PubMed, Embase and ScieLO using the terms of MeSH and its associates or synonyms for "obsessivecompulsive disorder", "gene" and "genetic association studies". Results: We selected 105 papers and described their main results grouped as genes related to: serotonin, dopamine, glutamate, GABA, white matter, immune system, hormones and other genes. Discussion: There is high variability between findings of association studies among the several candidate genes studied in OCD. Glutamate-related genes are promising candidates for OCD, but there is no conclusive association between any of the candidate genes studied and OCD. Association studies with large sample size, evaluation of more homogeneous subgroups of phenotype and meta-analyses are still needed.

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Section: Genes Related To Serotonincontrasting

confidence: 88%

Estudos de associação genética no transtorno obsessivo-compulsivo

Sampaio¹,

Lins²,

Daltro-Oliveira³

et al. 2013

Rev. psiquiatr. clín.

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show abstract

“…For instance, obsessive-compulsive spectrum disorders share a common dysregulation in serotonin function and genetic polymorphisms of serotonergic genes (Bloch et al, 2008; Saiz et al, 2008). Similarly, impulsivity has been linked to low serotonin in a range of behavioral disturbances including alcohol use disorders, binge eating, drug use, and risky sexual behavior (Cyders & Smith, 2008; Fischer, Smith, & Cyders, 2008).…”

Section: Basic Model Of Bn Pathologymentioning

confidence: 99%

Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa

Hildebrandt

Alfano

Tricamo

et al. 2010

Clinical Psychology Review

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Serotonergic dysregulation is thought to underlie much of the pathology in bulimia nervosa (BN). The purpose of this review is to expand the serotonergic model by incorporating specific and nonspecific contributions of estrogens to the development and maintenance of bulimic pathology in order to guide research from molecular genetics to novel therapeutics for BN. Special emphasis is given to the organizing theory of general brain arousal which allows for integration of specific and nonspecific effects of these systems on behavioral endpoints such as binge eating or purging as well as arousal states such as fear, novelty seeking, or sex. Regulation of the serotonergic system by estrogens is explored, and genetic, epigenetic, and environmental estrogen effects on bulimic pathology and risk factors are discussed. Genetic and neuroscientific research support this two-system conceptualization of BN with both contributions to the developmental and maintenance of the disorder. Implications of an estrogenic-serotonergic model of BN are discussed as well as guidelines and suggestions for future research and novel therapeutic targets.

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“…Additional candidate genes in the glutamate system have also been studied, including GRIN2B , which shows evidence of association in some but not all studies (Arnold et al, 2004, Alonso et al, 2012, Cai et al, 2013). The other leading candidate gene is the serotonin transporter, SLC6A4 , with both common and rare variants exhibiting association in some studies (Ozaki et al, 2003, Dickel et al, 2007, Grados et al, 2007, Saiz et al, 2008, Wendland et al, 2008), but not all (Taylor, 2013). The dopaminergic system ( COMT and DRD4 ) has also been implicated via gene association studies; however these findings have yet to be replicated (Billett et al, 1998, Pooley et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology

Zike

Hong

et al. 2017

Neuroscience

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Obsessive Compulsive Disorder (OCD) is a common neuropsychiatric disorder with unknown molecular underpinnings. Identification of genetic and non-genetic risk factors has largely been elusive, primarily because of a lack of power. In contrast, neuroimaging has consistently implicated the cortico-striatal-thalamo-cortical (CSTC) circuits in OCD. Pharmacological treatment studies also show specificity, with consistent response of OCD symptoms to chronic treatment with serotonin reuptake inhibitors; although most patients are left with residual impairment. In theory, animal models could provide a bridge from the neuroimaging and pharmacology data to an understanding of pathophysiology at the cellular and molecular level. Several mouse models have been proposed using genetic, immunological, pharmacological, and optogenetic tools. These experimental model systems allow testing of hypotheses about the origins of compulsive behavior. Several models have generated behavior that appears compulsive-like, particularly excessive grooming, and some have demonstrated response to chronic serotonin reuptake inhibitors, establishing both face validity and predictive validity. Construct validity is more difficult to establish in the context of a limited understanding of OCD risk factors. Our current models may help us to dissect the circuits and molecular pathways that can elicit OCD-relevant behavior in rodents. We can hope that this growing understanding, coupled with developing technology, will prepare us when robust OCD risk factors are better understood.

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Association study between obsessive–compulsive disorder and serotonergic candidate genes

Cited by 49 publications

References 52 publications

Estudos de associação genética no transtorno obsessivo-compulsivo

Estudos de associação genética no transtorno obsessivo-compulsivo

Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa

Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology

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