Association study between interleukin-1β gene (IL-1β) and schizophrenia

Yang, Jianzhong; Si, Tianmei; Ling, Yansu; Ruan, Yan; Han, Yonghua; Wang, Xiling; Zhou, Mo; Zhang, Darong; Zhang, Hongyan; Kong, Qingmei; Liu, Cui; Li, Xueni; Yu, Yaqin; Liu, Shuzeng; Shen, Liang; Ma, Dalong; Wei, Jun; Zhang, Dai

doi:10.1016/s0024-3205(03)00248-0

Cited by 16 publications

(8 citation statements)

References 12 publications

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“…13,[41][42][43] Many components of the immune system have been studied for their roles in the disease, including IL2, 13,44 IL6 45,46 and TNF-a. 47 We have reported that IL3 is associated with schizophrenia and the associations observed are sex-specific and FHdependent.…”

Section: Discussionmentioning

confidence: 99%

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

et al. 2007

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Colony stimulating factor 2 receptor, beta (CSF2RB) is the shared subunit of receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2) and IL5, and is responsible for the initiation of signal transduction triggered by ligand binding. In our previous study, we showed the evidence that the IL3 gene is associated with schizophrenia and the associations observed are sex-specific and dependent on family history (FH). In this article, we studied 10 singlenucleotide polymorphisms in the CSF2RB gene in the Irish Study of High-Density Schizophrenia Families (ISHDSF) and the Irish Case -Control Study of Schizophrenia (ICCSS), and tested allele and haplotype associations with schizophrenia. Using the pedigree disequilibrium test, we found that two markers (rs11705394 and rs7285064) reached nominal significance. In sex-stratified analyses, for both the markers the association signals were mainly derived from male subjects. In the ICCSS sample, we found that several markers (rs2072707, rs2284031 and rs909486) showed sex-specific and FH-dependent associations with schizophrenia. In multimarker haplotype analyses, both ISHDSF and ICCSS samples showed globally significant associations in multiple linkage disequilibrium (LD) blocks sharing minimal LD. Since CSF2RB is essential for IL3 signaling, the findings that both IL3 and CSF2RB showed sex-specific and FH-dependent associations suggest that the IL3 pathway is involved in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

et al. 2007

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“…In addition, other genetic studies have reported a negative association between the IL-1b gene and schizophrenia. [39][40][41] It should be noted that none of these studies used the haplotypic approach presented in the current report: owing to the strong linkage disequilibrium between loci located on the IL-1 cluster, analysis of haplotypes would be the most appropriate method to study the involvement of this genomic region in psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder

Papiol¹,

Rosa²,

Gutiérrez³

et al. 2004

Journal of Medical Genetics

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“…The authors tested three SNP, C-889T (rs1800587), Phe105Phe (rs1143634) and C-511T (rs16944), and a VNTR [(86 bp)n], which were investigated in previous studies. [32][33][34][35][36][37][38][39][40][41][42] The remaining five SNP, JST006818 (rs2071376), JST006815 (rs2071373), JST075040 (rs3213448), JST006948 (rs2071459) and JST006488 (rs315952), were selected from the JSNP database (http://snp.ims.u-tokyo.ac.jp/index_ja.html). 43 All SNP were genotyped using the TaqMan 5′exonuclease assay, as described previously.…”

Section: Methodsmentioning

confidence: 99%

“…32 Subsequently, studies replicating this work have provided confirmation that these polymorphisms and haplotypes consisting of these variants were associated with schizophrenia. [33][34][35] However, contradictory results have also been reported, [36][37][38][39][40][41][42] and these inconsistencies require further investigation. Therefore, the authors performed a case-control association study in Japanese subjects to assess whether the IL1 gene complex was implicated in vulnerability to schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between the interleukin‐1 gene complex and schizophrenia in a Japanese population

Watanabe

Nunokawa

Kaneko

et al. 2007

Psychiatry Clin Neurosci

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Interleukin-1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia. Recent genetic studies have revealed that the IL1 gene complex (IL,1 alpha, IL1, beta and IL1 receptor antagonist) was associated with schizophrenia, although contradictory findings have also been reported. To assess whether the IL1 gene complex was implicated in vulnerability to schizophrenia, the authors conducted a case-control association study (416 patients with schizophrenia and 440 control subjects) for nine polymorphisms in Japanese subjects. The authors found no association between the IL1 gene complex polymorphisms and schizophrenia using either singlemarker or haplotype analyses. The results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population.

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Association study between interleukin-1β gene (IL-1β) and schizophrenia

Cited by 16 publications

References 12 publications

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder

Lack of association between the interleukin‐1 gene complex and schizophrenia in a Japanese population

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