Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer

Association Studies Between XRCC1, XRCC2, XRCC3 Polymorphisms and Differentiated Thyroid Carcinoma

“…As suggested by earlier studies, polymorphisms of these genes are related to thyroid cancer risk [6,[20][21][22][23][24]. However, no conclusive result has been reported due to the conflicting findings among different studies.…”

X-Ray Repair Cross-Complementing Group 1(XRCC1) Genetic Polymorphisms and Thyroid Carcinoma Risk: a Meta-Analysis

“…However, the results were not consistent. For example, Ryu's study (Ryu et al, 2011) have found that the XRCC1 Arg194Trp Arg/ Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (OR with 95 CI;), however, no such association was observed in Esfahani's study (Fard-Esfahani et al, 2011); Quispes's study (García-Quispes et al, 2011) have found a positive association (OR = 1.58, 95% CI 1.05-2.46) for XRCC1 Arg280His, however, no such tendency was found in Chiang's study (Chiang et al, 2008); Akulevich's study (Akulevich et al, 2009) have found that XRCC1 Arg399Gln polymorphisms was associated with a decreased risk of PTC according to the multiplicative and dominant models of inheritance, however, Siraj's study (Siraj et al, 2008) found no such association. These inconsistent results failed to clarify the complicated relationship between XRCC1 polymorphism and thyroid cancer risk.…”

“…There are also some case-control studies conducted to explore the association of SNPs of XRCC1 and thyroid cancer risk (Zhu et al, 2004;Chiang et al, 2008;Siraj et al, 2008;Akulevich et al, 2009;Ho et al, 2009;Sigurdson et al, 2009;Fard-Esfahani et al, 2011;García-Quispes et al, 2011;Ryu et al, 2011). However, the results were not consistent.…”

DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms

“…The results in our study do not reveal an association between XRCC1 Arg194Trp genotypes and thyroid cancer risk, and these differences might be due a different risk factors for thyroid tumours (exposure to ionizing radiation (Sigurdson et al, 2009) versus sporadic tumours), and genetic background of different populations. Concerning XRCC1 Arg280His polymorphism only a positive association was described in Caucasian populations (Garcia-Quispes et al, 2011). Interestingly, in white non-Hispanics, the XRCC1 399Gln variant allele may be associated with decreased risk of DTC, and in Caucasians, who lived in the areas of the Russian Federation and Belarus contaminated with radionuclides from Chernobyl fallout, it was observed that the XRCC1 Arg399Gln polymorphism, regardless of radiation exposure, was associated with a decreased risk of Papillary Thyroid Carcinoma (PTC) according to the multiplicative and dominant models of inheritance (Sigurdson et al, 2009).…”