Association of Wilms tumour with spina bifida occulta

Abstract

Sir: Sulphite oxidase deficiency, either isolated or related to the absence of the hepatic molybdenum cofactor, has been described in neurologically disturbed and mentally retarded patients [1]. Clinical symptoms are probably the consequence of endogenous sulphite intoxication. Treatment should eliminate the overflow of sulphite. This was recently attempted with D-penicillamine and 2-mercaptoethane sulphonic acid [1,6]. Both substances failed to improve the profile of sulphur containing metabolites in the urine. These negative results are explained by our in vitro assays for sulphonation of oxidized D-penicillamine and other sulphur-containing compounds. Oxidized forms of these compounds were either commercially available or prepared by passing air through solutions of thiol compounds in Tris-HC1 buffer at pH 8.0. Sodium metabisulphite was added as sulphonation agent to a final concentration one tenth that of the thiol compound. Unreacted sulphite was determined by the method of Samyn and Carton [4]. D-

Pediatric cancer risk in association with birth defects: A systematic review

“…Stronger associations were reported for non-WT associated BDs than WT-associated BDs in one study [ 78 ]. Two studies reported significant positive associations between WT and spina bifida [ 79 , 80 ]. WT was also reported as positively associated with eye/face/neck BDs and chromosomal BDs [ 17 ].…”

Wilms' Tumor Associated With Vertebral Anomalies

“…2,4 In Kajtar et al's study, 4 the rate of spina bifida occulta in patients with WT was reported significantly higher than that of normal population. Several studies also have suggested an association of extrarenal or intrarenal WT with overt or occult spinal dysraphism.…”

“…2,3 Some studies demonstrate significant correlations between tumors and malformations of the kidneys and urinary tract and vertebral anomalies. 4,5 There are scanty case reports describing an association between WT and vertebral malformations. Here, we report a WT patient associated with butterfly T3, T8 vertebrae and T2, T7 hemivertebrae in vertebral column.…”

Spina bifida and pediatric cancers

“…2,3 Later studies with greater statistical power were able to stratify by cancer type, and reported increased risks for acute lymphoblastic leukemia (ALL), hepatoblastoma, central nervous system (CNS) tumors, Wilms tumor, Ewing sarcoma, and non-rhabdomyosarcoma soft tissue sarcomas, although findings were not always consistent likely due to small sample sizes. [4][5][6][7][8][9][10] In addition, spina bifida aperta was reported in family members of Wilms tumor cases. 9 Because both cancer and spina bifida are rare events, however, there are few published studies.…”

“…[4][5][6][7][8][9][10] In addition, spina bifida aperta was reported in family members of Wilms tumor cases. 9 Because both cancer and spina bifida are rare events, however, there are few published studies. Variation in results may occur between studies that relied on birth defect registries, in comparison to studies ascertaining spina bifida by physical exam or imaging.…”